公开(公告)号：US09625444B2

公开(公告)日：2017-04-18

申请号：US14221018

申请日：2014-03-20

申请人： Sanofi Pasteur VaxDesign Corporation

发明人： William L Warren ,  Heather Fahlenkamp ,  Russell Higbee ,  Anatoly Kachurin ,  Conan Li ,  Mike Nguyen ,  Robert Parkhill ,  Guzman Sanchez-Schmitz ,  Darrell J. Irvine ,  Gwendalyn J. Randolph ,  Nir Hacohen ,  Bruce Torbett

IPC分类号： C12N5/00 ,  C12N5/02 ,  A61K38/00 ,  G01N33/50 ,  C12N5/071

CPC分类号： G01N33/5008 ,  C12N5/0697 ,  C12N5/0698 ,  C12N2501/21 ,  C12N2502/094 ,  C12N2502/11 ,  C12N2502/1107 ,  C12N2502/1114 ,  C12N2502/1121 ,  C12N2502/1157 ,  C12N2502/1192 ,  C12N2502/1323 ,  C12N2502/28 ,  C12N2503/04 ,  C12N2513/00 ,  C12N2531/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2535/10 ,  G01N33/5088 ,  G01N2500/10

摘要： The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.