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公开(公告)号：US10272403B2
公开(公告)日：2019-04-30
申请号：US15529256
申请日：2015-10-20
摘要： A mixing device (10) comprises a flexible container (14), at least one stirring element (22) and at least one baffle (24). The baffle (24) is formed on the inside on a circumferential side wall (16) of the flexible container (14) and has a free end protruding into the interior of the container (14). A main application of the mixing device (10) is considered to be the use as disposable bioreactor.
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公开(公告)号：US20230332091A1
公开(公告)日：2023-10-19
申请号：US18044641
申请日：2021-06-17
发明人： Marco Leupold , Simon Topp-Manske , Ute Husemann , Sebastian Ruhl , Sascha Gärtner , Yannick Stapel , Regina Wollschmidt , Gerhard Greller , Thomas Dreher
CPC分类号： C12M41/42 , C12M23/28 , C12M23/14 , C12M27/02 , C12M23/22 , C12M23/48 , C12M41/12 , C12M27/20
摘要： A bioreactor system for receiving a disposable bioreactor bag comprises a receiving container having a container wall which defines a receiving space in which the disposable bioreactor bag is received in an operating state of the bioreactor system. A stirring system projects at least partially into the receiving space and is designed and configured to stir a biomedium present in the disposable bioreactor bag in the operating state of the bioreactor system. At least one baffle, which makes the receiving space smaller and differs from the container wall, serves to reduce a laminar flow of the biomedium. A temperature control medium flows through at least part of the at least one baffle, said temperature control medium controlling the temperature of the baffle.
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公开(公告)号：US20220372425A1
公开(公告)日：2022-11-24
申请号：US17761156
申请日：2020-09-10
摘要： A system for an automated production of high cell density seed culture, HCDC, preparations, for cryo-preservation comprising a cell expansion device for growing a HCDC in a medium inside a device volume of the cell expansion device, at least one sensor for collecting data by at least temporally monitoring at least one parameter being indicative of the physiological state of the HCDC; and a control unit for processing the collected data to determine whether at least one predetermined criterion is fulfilled by the monitored parameter to control, based on whether the at least one predetermined criterion is fulfilled by the monitored parameter, at least a partial exchange of the medium by a cryo-protective agent, CPA.
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公开(公告)号：US20170259231A1
公开(公告)日：2017-09-14
申请号：US15529256
申请日：2015-10-20
CPC分类号： B01F15/0085 , B01F7/20 , B01F15/00896 , C12M1/02 , C12M23/26 , C12M27/02 , C12M27/20
摘要： A mixing device (10) comprises a flexible container (14), at least one stirring element (22) and at least one baffle (24). The baffle (24) is formed on the inside on a circumferential side wall (16) of the flexible container (14) and has a free end protruding into the interior of the container (14). A main application of the mixing device (10) is considered to be the use as disposable bioreactor.
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