利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

68 条记录 (耗时 0.015 秒)

    Closed cell culturing and harvesting system
    2.
    发明授权
    Closed cell culturing and harvesting system 有权

    公开(公告)号：US11952564B2

    公开(公告)日：2024-04-09

    申请号：US17899241

    申请日：2022-08-30

    申请人： Shanghai Longevity Co., Ltd.

    发明人： Tian Xia ,  Ke Ma

    IPC分类号： C12M1/26 ,  C12M1/00 ,  C12M1/34 ,  C12M3/04

    CPC分类号： C12M33/14 ,  C12M23/22 ,  C12M23/38 ,  C12M27/10 ,  C12M41/42

    摘要： A bioreactor includes a base and a lid. The base includes two opposing curved or convoluted surfaces, two opposing flat surfaces, a window disposed on one of the flat surfaces, the window having a higher degree of transparency compared to other portions of the base, wherein images or videos of cells are captured through the window by non-invasive ISM device, and a rounded bottom. The lid is attachable to the base. The lid includes a shaft and a semipermeable membrane attached to the shaft, the semipermeable membrane being permeable to oxygen but impermeable to viruses and bacteria. The PAT-based online analysis directs the adaptive manipulations of bioreactor towards efficient, automated, and GMP-compliant clinical protocols of cell culture.

    CULTURE METHOD FOR CELLS AND PRODUCTION METHOD FOR USEFUL SUBSTANCE
    3.
    发明公开
    CULTURE METHOD FOR CELLS AND PRODUCTION METHOD FOR USEFUL SUBSTANCE 审中-公开

    公开(公告)号：US20240002784A1

    公开(公告)日：2024-01-04

    申请号：US18468223

    申请日：2023-09-15

    申请人： FUJIFILM Corporation

    发明人： Atsushi INADA ,  Kosuke TANIGUCHI ,  Naoto TAKAHASHI

    IPC分类号： C12N5/00 ,  C12M1/34

    CPC分类号： C12N5/0018 ,  C12M41/42 ,  C12N2500/02

    摘要： An object to be achieved by the present invention is to provide a culture method for cells, which makes it possible to suppress oxygen deficiency of cells in a case where the cell is cultured at a high density, and a production method for a useful substance using the culture method for cells. According to the present invention, there is provided a culture method for cells, in which a relationship between a stirring power P/V per unit volume, a dissolved oxygen concentration CL0, and a viable cell density VCD satisfies a condition of Expression 1, in cell culture in which the viable cell density is 60×106 cells/mL or more.


    0.0059×exp[0.0243×(P/V)]×CL0/VCD≥1.10×10−17   Expression 1:

    In the expression, L0 indicates a dissolved oxygen concentration [mol/mL]; VCD indicates a viable cell density [cells/mL]; and P/V indicates a stirring power [W/m3] per unit volume, which is defined by a predetermined expression.

    A BIOREACTOR SYSTEM AND METHOD THEREOF
    7.
    发明申请
    A BIOREACTOR SYSTEM AND METHOD THEREOF 审中-公开

    公开(公告)号：US20180187139A1

    公开(公告)日：2018-07-05

    申请号：US15578635

    申请日：2016-10-04

    申请人： Ravindrakumar Dhirubhai Patel

    发明人： Ravindrakumar Dhirubhai Patel

    IPC分类号： C12M3/06 ,  C12M1/12 ,  C12M1/00 ,  C12M1/34

    CPC分类号： C12M27/14 ,  C12M23/40 ,  C12M25/06 ,  C12M27/20 ,  C12M41/14 ,  C12M41/26 ,  C12M41/32 ,  C12M41/40 ,  C12M41/42

    摘要： The present invention relates to bioreactor system and method thereof wherein support matrix (2) comprises at last one central shaft and plurality of peripheral shaft being radially surrounds central shaft. Arrays of discs (11) are mounted along the shaft by defining interspatial vicinities between two successive plates. Thus, discs mounted on peripheral shafts are rotated within the interspatial vicinity of discs of central shaft to ensures sufficient mixing and avoid stagnant fluidic zones which is created when discs are mounted closely apart from each other on shafts. Further, plurality of deflector vanes that are axially provided along the length of the central shaft to redirect substantially co-axial direction fluid flow into interior of culture vessel and more specifically towards the central axis. Thus, bioreactor system provides scalable and disposable bioreactor with efficient mixing and homogeneous conditions and thereby supports high density growth and maintenance of cells and other biological material.

    METHOD FOR ON-LINE OPTIMIZATION OF A FED-BATCH FERMENTATION UNIT TO MAXIMIZE THE PRODUCT YIELD
    9.
    发明申请
    METHOD FOR ON-LINE OPTIMIZATION OF A FED-BATCH FERMENTATION UNIT TO MAXIMIZE THE PRODUCT YIELD 审中-公开
    用于在线优化FED分批发酵单元以最大限度地提高产品产量的方法

    公开(公告)号：US20090117647A1

    公开(公告)日：2009-05-07

    申请号：US12349134

    申请日：2009-01-06

    申请人： Babji Buddhi Srinivasa ,  Jayant Modak Moreshwar

    发明人： Babji Buddhi Srinivasa ,  Jayant Modak Moreshwar

    IPC分类号： C12M1/02 ,  G06F19/00 ,  G06F17/10 ,  G06G7/66

    CPC分类号： C12M41/48 ,  C12M41/32 ,  C12M41/34 ,  C12M41/42

    摘要： A method for on-line optimization of fed-batch fermentation unit containing bacteria and nutrients is disclosed. Parameters of the fermenter model used in optimization calculations are estimated periodically to reduce the mismatch between the plant and the calculated values. The updated fermenter model is used to calculate the optimum sugar feed rate to maximize the product yield. The method/fermenter model is implemented as a software program in a PC that can be interfaced to plant control systems for on-line deployment in an actual plant environment. An on-line optimization system is useful to the plant operating personnel, to maximize the product yield from the fed-batch fermenter unit. In another aspect, a plant control system to control a fed-batch fermentation based on the described method is also disclosed.

    摘要翻译： 公开了一种用于在线优化含有细菌和营养物质的补料分批发酵装置的方法。 周期性地估计用于优化计算中的发酵罐模型的参数，以减少工厂与计算值之间的不匹配。 更新的发酵罐模型用于计算最佳糖进料速率以最大化产物产率。 方法/发酵罐模型被实现为PC中的软件程序，其可以连接到工厂控制系统以在实际的工厂环境中进行在线部署。 在线优化系统对于工厂操作人员是有用的，以使来自补料分批发酵器单元的产品产量最大化。 另一方面，还公开了一种基于所述方法控制补料分批发酵的植物控制系统。