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1.发明授权公开(公告)号：US10802033B2
公开(公告)日：2020-10-13
申请号：US15736030
申请日：2016-04-27
发明人： Mario Becker , Gerhard Greller , Christian Grimm , Thorsten Adams , Lars Boettcher , Henry Weichert
摘要： A method is provided for measuring status parameters of a fluid contained in a container (10). The container (10) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. The plate carries sensors (S1-S5) that are in operative contact with the internal chamber of the container (10) and connected for data exchange (14) with an external control unit (16) that receives and processes the measurement data from the sensors (S1-S5). The sensor plate also carries a temporarily inactive duplicate (D1-D5) of at least one of the sensors (S1-S5) that is activated if measurement data of the sensor (S1-S5) is classified as atypical in the context of an integrity or plausibility test carried out by the external control unit (16).
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公开(公告)号：US10272403B2
公开(公告)日：2019-04-30
申请号：US15529256
申请日：2015-10-20
摘要： A mixing device (10) comprises a flexible container (14), at least one stirring element (22) and at least one baffle (24). The baffle (24) is formed on the inside on a circumferential side wall (16) of the flexible container (14) and has a free end protruding into the interior of the container (14). A main application of the mixing device (10) is considered to be the use as disposable bioreactor.
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公开(公告)号：US10130922B2
公开(公告)日：2018-11-20
申请号：US14900625
申请日：2014-05-28
发明人： Reiner Seitz , Rainer Salzmann , Thomas Regen , Matthias Hielscher , Bernward Husemann , Stefan Zeuch , Ute Husemann , Gerhard Greller
摘要： A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.
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公开(公告)号：US09963668B2
公开(公告)日：2018-05-08
申请号：US14425330
申请日：2013-07-16
发明人： Oscar-Werner Reif , Gerhard Greller , Paschalis Nikoloudis , Ralf Lausch , Ute Husemann , Thomas Loewe , Thomas Friese , Thomas Dreher
CPC分类号： C12M29/04 , B01D46/0023 , B01D53/22 , B01D71/36 , B01D2053/221 , B01D2325/02 , B01D2325/38 , C12M29/20 , C12M37/02 , C12M47/18
摘要： The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.
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公开(公告)号：US20160151749A1
公开(公告)日：2016-06-02
申请号：US14900625
申请日：2014-05-28
发明人： Reiner Seitz , Rainer Salzmann , Thomas Regen , Matthias Hielscher , Bernward Husemann , Stefan Zeuch , Ute Husemann , Gerhard Greller
CPC分类号： B01F7/00683 , B01F15/00441 , B01F15/00707 , B01F15/0085 , B01F2015/00084 , B01F2015/0011 , C12M23/26 , C12M23/28 , C12M27/02 , C12M37/04 , F16C19/545 , F16C33/76 , F16J15/002
摘要： A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.
摘要翻译： 容器具有限定容器内部的壁和用于将轴穿过壁进入容器内部的轴壳体。 轴壳体限定了环形盖，其具有通过面向插座内部的内端面连接的间隔开的内壁和外壁。 轴引导部分具有面向插座内部的端部和限定相对于轴壳体的内壁的间隙的外表面。 轴引导部分具有与其外表面间隔开并平行的环形壁。 环形壁在轴壳体的内壁的自由端上延伸，并且通过至少一个密封件密封到轴壳体的内壁和外壁。 轴引导部件通过径向球轴承和轴向滚珠轴承安装在轴壳体中。
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6.发明申请STIRRER INSTALLATION AID AND METHOD FOR INSTALLING A STIRRER ELEMENT IN A BIOREACTOR 有权用于安装生物反应器中的刺激元件的刺激安装辅助和方法公开(公告)号：US20150273416A1
公开(公告)日：2015-10-01
申请号：US14432616
申请日：2013-08-29
CPC分类号： B01F15/00 , B01F7/00008 , B01F15/00922 , C12M27/02 , Y10T29/49316
摘要： A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
摘要翻译： 生物反应器具有可由驱动器驱动并且在其上定位有搅拌器元件的搅拌器轴。 搅拌器元件的位置由搅拌器安装辅助器确定。 搅拌器安装辅助件具有自由端，其具有抵靠表面，搅拌器元件的自由端邻接在该邻接表面上。 搅拌器安装辅助件被设计为套筒，其包括在套筒的轴向端部之间延伸的狭槽。 槽由壁的相对侧面限定，套筒放置在搅拌器轴上。 搅拌器安装辅助件可以从搅拌器轴横向拉出。 还提供了一种将搅拌器元件安装在设置在生物反应器中的搅拌器轴上的方法。
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公开(公告)号：US20150232799A1
公开(公告)日：2015-08-20
申请号：US14425330
申请日：2013-07-16
发明人： Oscar-Werner Reif , Gerhard Greller , Paschalis Nikoloudis , Ralf Lausch , Ute Husemann , Thomas Loewe , Thomas Friese , Thomas Dreher
CPC分类号： C12M29/04 , B01D46/0023 , B01D53/22 , B01D71/36 , B01D2053/221 , B01D2325/02 , B01D2325/38 , C12M29/20 , C12M37/02 , C12M47/18
摘要： The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.
摘要翻译： 本发明涉及用于在生物反应器中培养细胞的装置，其从反应器内部引出的废气管线包括具有无菌过滤微过滤器膜的废空气过滤器，其中至少一个具有疏水性过滤材料的预过滤器 被放置在废气过滤器的上游朝向反应器内部。
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8.发明授权公开(公告)号：US10968421B2
公开(公告)日：2021-04-06
申请号：US15737847
申请日：2016-04-27
发明人： Mario Becker , Gerhard Greller , Christian Grimm , Thorsten Adams , Lars Boettcher , Henry Weichert
摘要： A method is provided for measuring parameters of state of a fluid contained in a container (10, 10′) that has a sensor carrier plate with plural sensors (S01-S10, S01′-S10′). Each sensor has a sensor head in operative contact with the interior of the container (10, 10′) and in operative contact with an external control unit (12). The external control unit (12) receives measurement data generated by the sensor heads of active sensors via their communication link and processes the data. An activation data record (24, 24′) is assigned to each sensor (S01-S10, S01′-S10′) and is recorded in a manner that is accessible for the external control unit (12). The external control unit (12) first accesses the activation data records (24, 24′), then classifies the sensors (S01-S10, S01′-S10′) as activatable or nonactivatable sensors, and subsequently activates only those sensors classified as activatable sensors.
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公开(公告)号：US09993782B2
公开(公告)日：2018-06-12
申请号：US14432616
申请日：2013-08-29
CPC分类号： B01F15/00 , B01F7/00008 , B01F15/00922 , C12M27/02 , Y10T29/49316
摘要： A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
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公开(公告)号：US20160215247A1
公开(公告)日：2016-07-28
申请号：US14917626
申请日：2014-08-18
IPC分类号： C12M1/00
摘要： A container (1) has a flexible wall (2) and at least one emptying tube (4, 4′, 4″) that projects through a wall aperture (7) into the container interior (3) surrounded by the flexible wall (2). The free end (12) of the emptying tube has an emptying opening (13) that can be set in position vertically to different emptying heights (14). The container (1) is distinguished in that an adapter piece (8), in which the emptying tube (4, 4′, 4″) is held in a longitudinally displaceable manner, is arranged in the wall aperture and in that a portion of the emptying tube (4, 4′, 4″) is surrounded by a flexible sheath (5) that is connected at a first end (11) to the emptying tube (4, 4′, 4″) and at its second end (10), which is remote from the first end (11), to the wall (2) or the adapter piece (8).
摘要翻译： 容器（1）具有柔性壁（2）和至少一个通过壁孔（7）突出到由柔性壁（2）包围的容器内部（3）中的排空管（4,4'，4“） ）。 排空管的自由端（12）具有可以垂直设置到不同排空高度（14）的排空开口（13）。 容器（1）的特征在于，其中排空管（4,4'，4“）以可纵向移位的方式保持的适配器件（8）布置在壁孔中，并且其中一部分 排空管（4,4'，4“）由柔性护套（5）围绕，柔性护套（5）在第一端（11）连接到排空管（4,4'，4”）并在其第二端 10）远离第一端（11）到壁（2）或适配器件（8）。
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