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公开(公告)号：US06927230B2
公开(公告)日：2005-08-09
申请号：US10344416
申请日：2002-10-30
申请人： Satoshi Aoki , Toshiya Nakagawa , Nobukiyo Konishi , Katsuya Nakamura , Hiroki Omori , Ariyoshi Kubota , Norio Hashimoto
发明人： Satoshi Aoki , Toshiya Nakagawa , Nobukiyo Konishi , Katsuya Nakamura , Hiroki Omori , Ariyoshi Kubota , Norio Hashimoto
IPC分类号： A61K31/4196 , A61K31/42 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61P7/02 , A61P19/02 , A61P19/06 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D249/12
CPC分类号： C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： A compound of the formula (I): wherein R1 is lower alkyl which is optionally substituted with halogen, cyano, N,N-di(lower)alkylcarbamoyl, phenyl optionally substituted with halogen, or heterocyclic group, cyclo(lower)alkyl, lower alkynyl, or N,N-di(lower)alkylcarbamoyl; R2 is lower alkyl, lower alkoxy, cyano, or 1H-pyrrol-1-yl; R3 is lower alkyl, lower alkoxy, or cyano; X is O, S, SO or SO2; Y and Z are each CH or N; and m is 0 or 1; or salts thereof, which are useful as a medicament.
摘要翻译： 氰基，N，N-二（低级）烷基氨基甲酰基，任选被卤素取代的苯基或杂环基的式（I）化合物：其中R 1是任选被卤素， ，低级（低级）烷基，低级炔基或N，N-二（低级）烷基氨基甲酰基; R 2是低级烷基，低级烷氧基，氰基或1H-吡咯-1-基; R 3是低级烷基，低级烷氧基或氰基; X是O，S，SO或SO 2; Y和Z各自为CH或N; m为0或1; 或其盐，其可用作药物。
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2.发明申请Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity 失效具有腺苷脱氨酶抑制活性的咪唑4-甲酰胺化合物公开(公告)号：US20050159462A1
公开(公告)日：2005-07-21
申请号：US10503585
申请日：2003-02-12
IPC分类号： A61K31/423 , A61K45/00 , A61P1/06 , A61P25/00 , A61P25/04 , A61P29/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P43/00 , C07D403/06 , C07D405/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , A61K31/428 , C07D413/02 , C07D417/02
CPC分类号： C07D403/06 , C07D417/06
摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
摘要翻译： 具有由式（I）表示的腺苷脱氨酶抑制活性的咪唑化合物：其中R 1是任选取代的芳基或任选取代的杂芳基，R 2是低级烷基; R 3是羟基或被保护的羟基; X是O或S; 和-A-是低级亚烷基，其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。
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公开(公告)号：US5571810A
公开(公告)日：1996-11-05
申请号：US422545
申请日：1995-04-13
IPC分类号： C07D333/12 , C07D333/22 , C07D333/24 , C07D333/32 , C07D333/34 , C07D333/36 , C07D333/38 , C07D409/12 , A61K31/535 , A61K31/38 , A61K31/42 , A61K31/495
CPC分类号： C07D409/12 , C07D333/12 , C07D333/22 , C07D333/24 , C07D333/32 , C07D333/34 , C07D333/36 , C07D333/38
摘要： This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsubstituted amino, sulfo, substituted or unsubstituted sulfamoyl, N-containing heterocyclicsulfonyl, hydoxy, substituted or unsubstituted heterocyclic group,R.sup.2 is substituted or unsubstituted aryl, andR.sup.3 is substituted or unsubstituted aryl, provided that R.sup.3 is aryl substituted with substituent(s) selected from the group consisting of amino, mono(lower)-alkylamino, acylamino, lower alkyl(acyl)amino and sulfamoyl when R.sup.1 is hydrogen, halogen or cyano, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
摘要翻译： 本发明涉及具有抗炎和止痛活性的新噻吩衍生物，由通式[I]表示：其中R 1是氢，卤素，氰基，取代的低级烷基，取代或未取代的低级烯基，酰基，硝基 取代或未取代的氨基，磺基，取代或未取代的氨磺酰基，含N杂环基磺酰基，羟基，取代或未取代的杂环基，R2为取代或未取代的芳基，R3为取代或未取代的芳基，条件是R3为被取代基取代的芳基 s）选自氨基，单（低级） - 烷基氨基，酰氨基，低级烷基（酰基）氨基和氨磺酰基，当R 1为氢时，卤素或氰基，及其药学上可接受的盐，其制备方法和 包含其的药物组合物。
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公开(公告)号：US20070043084A1
公开(公告)日：2007-02-22
申请号：US10555656
申请日：2004-04-26
IPC分类号： A61K31/444 , A61K31/4439 , C07D403/04
CPC分类号： C07D401/12 , C07D233/90 , C07D417/12
摘要： A compound of the formula (1): wherein R1 is cyano, and the like; R2 is hydroxy, and the like; R3 is (lower)alkoxy, and the like; X and Y are each CH or N; or pharmaceutically acceptable salts thereof, which are useful as a medicament.
摘要翻译： 式（1）的化合物：其中R 1是氰基等; R 2是羟基等; R 3是（低级）烷氧基等; X和Y各自为CH或N; 或其药学上可接受的盐，其可用作药物。
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公开(公告)号：US20060128757A1
公开(公告)日：2006-06-15
申请号：US11348408
申请日：2006-02-07
申请人： Junya Ishida , Hirofumi Yamamoto , Nobukiyo Konishi , Masataka Morita , Katsuya Nakamura , Susumu Miyata , Takehiro Ochi , Yoshiaki Morita , Eiji Yoshimi , Kanae Kuroda
发明人： Junya Ishida , Hirofumi Yamamoto , Nobukiyo Konishi , Masataka Morita , Katsuya Nakamura , Susumu Miyata , Takehiro Ochi , Yoshiaki Morita , Eiji Yoshimi , Kanae Kuroda
IPC分类号： A61K31/444 , A61K31/4415 , A61K31/44 , C07D401/04
CPC分类号： C07D213/30 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/48 , C07D213/61 , C07D213/82 , C07D213/84 , C07D213/85
摘要： A compound of the formula (I): wherein R1 is hydrogen, halogen, carbamoyl, cyano, formyl, or lower alkyl optionally substituted with halogen, amino or a protected amino; R2 is hydrogen, halogen, cyano or lower alkoxy; R3 is phenyl or pyridyl, each of which is substituted with lower alkoxy; and R4 is lower alkoxy; provided that either R1 or R2 is hydrogen, then the other is other than hydrogen, or its salts, which are useful as a medicament.
摘要翻译： 式（I）的化合物：其中R 1是氢，卤素，氨基甲酰基，氰基，甲酰基或任选被卤素，氨基或被保护的氨基取代的低级烷基; R 2是氢，卤素，氰基或低级烷氧基; R 3是苯基或吡啶基，各自被低级烷氧基取代; R 4是低级烷氧基; 条件是R 1或R 2 2都是氢，则另一个不是用作药物的氢或其盐。
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公开(公告)号：US5134142A
公开(公告)日：1992-07-28
申请号：US582358
申请日：1990-09-14
IPC分类号： C07D231/10 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61P1/02 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/18 , C07D231/38 , C07D401/04 , C07D403/04 , C07D409/04
CPC分类号： C07D231/12 , C07D231/14 , C07D401/04 , C07D403/04 , C07D409/04
摘要： The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.
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7.发明授权Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity 失效具有腺苷脱氨酶抑制活性的咪唑4-甲酰胺化合物公开(公告)号：US07317107B2
公开(公告)日：2008-01-08
申请号：US10503585
申请日：2003-02-12
IPC分类号： C07D417/00 , C07D263/52 , C07D277/66 , A61K31/425 , A61K31/42
CPC分类号： C07D403/06 , C07D417/06
摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective
摘要翻译： 具有由式（I）表示的腺苷脱氨酶抑制活性的咪唑化合物：其中R 1是任选取代的芳基或任选取代的杂芳基，R 2是低级烷基; R 3是羟基或被保护的羟基; X是O或S; 和-A-是低级亚烷基，其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病
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公开(公告)号：US07599119B2
公开(公告)日：2009-10-06
申请号：US11331018
申请日：2006-01-13
IPC分类号： G02B1/10
CPC分类号： G02B6/4204 , G02B1/115
摘要： An antireflection coating provided on an optical element which passes through at least two wavelengths of light in the wavelength range of 1300-1600 nm, wherein the antireflection coating comprises: a high refractive index layer; a low refractive index layer having a refractive index lower than a refractive index of the high refractive index layer; and a supplementary layer having a composition different from a composition of the high refractive index layer or from a composition of the low refractive index layer, and being provided adjacent to the high refractive index layer or to the low refractive index layer.
摘要翻译： 一种防反射涂层，其设置在通过1300-1600nm波长范围内的至少两个波长的光学元件上，其中所述抗反射涂层包括：高折射率层; 折射率低于高折射率层的折射率的低折射率层; 以及具有与高折射率层的组成不同的组成或与低折射率层的组成不同的辅助层，并且邻近高折射率层或低折射率层设置。
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公开(公告)号：USD574681S1
公开(公告)日：2008-08-12
申请号：US29287116
申请日：2007-06-28
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公开(公告)号：US07316864B2
公开(公告)日：2008-01-08
申请号：US10493491
申请日：2002-10-25
CPC分类号： H01M4/13 , H01M4/62 , H01M4/622 , H01M10/052
摘要： A slurry composition for electrode comprising a binder, an active material, and a liquid medium, characterized in that the binder comprises a polymer (X) comprising 60 to 95 mole % of repeating units derived from acrylonitrile or methacrylonitrile and 5 to 30 mole % of repeating units derived from at least one kind of a monomer selected from 1-olefins and compounds represented by the following general formula (1): CH2═CR1—COOR2 wherein R1 represents a hydrogen atom or a methyl group and R2 represents an alkyl group; and the liquid medium is capable of dissolving the polymer (X). The slurry composition allows the manufacture of a lithium ion secondary battery having enhanced capacity and good charge-discharge cycle characteristics and good charge-discharge rate characteristics.
摘要翻译： 一种用于电极的浆料组合物，其包含粘合剂，活性材料和液体介质，其特征在于，所述粘合剂包含聚合物（X），其包含60至95摩尔％的衍生自丙烯腈或甲基丙烯腈的重复单元和5至30摩尔％ 衍生自至少一种选自1-烯烃的单体和由以下通式（1）表示的化合物的重复单元：CH 2 - 其中R 1表示氢原子或甲基，R 2表示烷基; 并且液体介质能够溶解聚合物（X）。 该浆料组合物可以制造具有增强的容量和良好的充放电循环特性以及良好的充放电速率特性的锂离子二次电池。
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