公开(公告)号：US5112471A

公开(公告)日：1992-05-12

申请号：US526782

申请日：1990-05-18

申请人： Yasuhisa Shibata ,  Naoto Oki ,  Satoshi Ozawa ,  Hiroyuki Miyagi

发明人： Yasuhisa Shibata ,  Naoto Oki ,  Satoshi Ozawa ,  Hiroyuki Miyagi

IPC分类号： G01N27/333

CPC分类号： G01N27/3335

摘要： The present invention provides an ion selective electrode for anions such as Cl.sup.- and cations such as Ca.sup.2+ which has a sensitive membrane comprising a polymer material and containing an ion sensitive material and a plasticizer. In thins ion selective electrode, the ion sensitive material is an ion exchanger such as a quaternary ammonium salt, a quaternary phosphonium salt or an organic phosphate and the plasticizer is a compound having the formula (1): ##STR1## wherein X represents an alkyl group, a phenyl group or a phenyl group to which a functional group bonds. As the plasticizer there may also be used a mixture of the compound of the formula (1) with an alcohol compound such as an alcohol having a dielectric constant of 10 or less and containing 10 or more carbon atoms or an ester compound.

公开(公告)号：US4936975A

公开(公告)日：1990-06-26

申请号：US221219

申请日：1988-07-19

申请人： Yasuhisa Shibata ,  Satoshi Ozawa ,  Naoto Oki ,  Hiroyuki Miyagi

发明人： Yasuhisa Shibata ,  Satoshi Ozawa ,  Naoto Oki ,  Hiroyuki Miyagi

IPC分类号： G01N27/30 ,  G01N27/333

CPC分类号： G01N27/3335

摘要： A liquid film type, chloride ion-selective electrode is provided with the present invention, which comprises a sensitive film containing a polymeric material as a support film material, a tetraalkyl ammonium salt with four alkyl group each having 10-24 carbon atoms as a chloride ion-sensitive substance, and a mixture of a linear alcohol having a low dielectric constant with at leastg 10 carbon atoms and an organic compound having a dielectric constant higher than that of said linear alcohol as plasticizer. This electrode has a high selectivity over lipophilic anions and hydrophilic anions, high accuracy ion measurements, and a long life.

公开(公告)号：US5116481A

公开(公告)日：1992-05-26

申请号：US504605

申请日：1990-04-05

申请人： Satoshi Ozawa ,  Naoto Oki ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

发明人： Satoshi Ozawa ,  Naoto Oki ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

IPC分类号： G01N27/333

CPC分类号： G01N27/3335

摘要： An anion-selective electrode of the present invention comprises, as anion sensitive substance, a tetraalkyl type, quaternary phosphonium salt having four alkyl radicals, each having 8 to 24 carbon atoms; a combination of a tetraalkyl onium salt having four alkyl radicals each having 10 to 24 carbon atoms, and an onium salt having one alkyl radical with 1 to 20 carbon atoms and three alkyl radicals with the proviso that the number of carbon atoms contained in the three alkyl radicals each is larger than that contained in the one alkyl radical; or a tetraalkyl type, quaternary onium salt having an asymmetrical molecular structure. The anion-selective electrode has good properties including selectivity and measurement accuracy. An anion-selective, field effect transistor or a chemical analysis apparatus, provided with the anion-selective sensitive substance, is suitable for measuring an anion concentration with a high accuracy.

摘要翻译： 作为阴离子敏感性物质，本发明的阴离子选择性电极含有四个烷基，具有四个烷基的季鏻盐，每个具有8至24个碳原子; 具有四个具有10至24个碳原子的烷基的四烷基鎓盐和具有一个具有1-20个碳原子的烷基和三个烷基的鎓盐的组合，条件是三价中包含的碳原子数 烷基各自大于一个烷基中所含的烷基; 或具有不对称分子结构的四烷基型季鎓盐。 阴离子选择性电极具有良好的性能，包括选择性和测量精度。 设置有阴离子选择性敏感物质的阴离子选择性场效应晶体管或化学分析装置适合于高精度地测量阴离子浓度。

公开(公告)号：US5102527A

公开(公告)日：1992-04-07

申请号：US654331

申请日：1991-02-12

申请人： Yasuhisa Shibata ,  Naoto Oki

发明人： Yasuhisa Shibata ,  Naoto Oki

IPC分类号： G01N27/414 ,  G01N27/333

CPC分类号： G01N27/3335

摘要： A calcium ion selective electrode having a sensitive membrane comprising an organic polymeric substance, a plasticizer and a calcium ion sensitive substance of neutral carrier type, wherein the dielectric constant of the plasticizer is 10 or less, thus remarkably improving the responsiveness and stability of the electrode.

摘要翻译： 一种具有敏感膜的钙离子选择性电极，其包含中性载体型的有机聚合物质，增塑剂和钙离子敏感性物质，其中增塑剂的介电常数为10以下，从而显着提高电极的响应性和稳定性 。

公开(公告)号：US5102525A

公开(公告)日：1992-04-07

申请号：US625014

申请日：1990-12-10

申请人： Yuji Miyahara ,  Keiji Tsukada ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

发明人： Yuji Miyahara ,  Keiji Tsukada ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

IPC分类号： G01N27/404 ,  G01N27/49

CPC分类号： G01N27/404

摘要： A planar oxygen sensor has an insulating substrate, a cathode formed on the insulating substrate generally at the center thereof; another electrode formed on the insulating substrate in a region other than the region of the cathode, a gas permeable membrane stretched to cover these electrodes and having its peripheral portion supported on the insulating substrate, and an electrolytic solution charged between the gas permeable membrane and the insulating substrate. A surface of the cathode is substantially in contact with the gas permeable membrane and is formed at a position higher than the gas permeable membrane support portion of the insulating substrate. A portion of the insulating substrate surface other than the region where the cathode is formed is recessed. Because the layer of electrolytic solution on the cathode is thin, oxygen molecules passing through the gas permeable membrane can immediately serve for the reduction at the cathode, thereby increasing the response speed of the planar oxygen sensor. Also, the amount of electrolytic solution is increased by the recess to extend the life of the sensor.

公开(公告)号：US4452682A

公开(公告)日：1984-06-05

申请号：US200264

申请日：1980-10-24

申请人： Yoshinori Takata ,  Hiroyuki Miyagi ,  Kunio Hirota ,  Yasuhisa Shibata ,  Kazuo Nidaira ,  Fusao Shirato

发明人： Yoshinori Takata ,  Hiroyuki Miyagi ,  Kunio Hirota ,  Yasuhisa Shibata ,  Kazuo Nidaira ,  Fusao Shirato

IPC分类号： G01N27/403 ,  G01N27/416 ,  G01N27/46

CPC分类号： G01N33/4915 ,  G01N33/492

摘要： An apparatus for electrochemically measuring clinical emergency check items of blood for a short time by flowthrough system, using a small amount of whole blood as a blood sample, which comprises a blood pH/gas component sensor unit, an electrolyte component sensor unit, and/or a biochemical component sensor unit, arranged in series in this order, a sampler and these sensor units being communicated with one another through a blood sample flow passage or channel, each of the sensor units being provided with sensor electrodes and at least one reference electrode as electrochemical sensor means.Detected values from each of the sensor units are transmitted to a computer or calculator through a current amplifier and/or a differential amplifier for a differential voltage from the voltage of the reference electrode to compute pH, pressure, or concentrations from the detected values, and numerically displayed on a display device connected to the computer.

摘要翻译： 一种用于使用少量全血作为血液样品的流过系统电化学测量血液临时紧急检查项目的装置，其包括血液pH /气体成分传感器单元，电解质成分传感器单元和/ 或生物化学成分传感器单元，其依次排列成一个采样器，并且这些传感器单元通过血液样本流动通道或通道彼此连通，每个传感器单元设置有传感器电极和至少一个参考电极 作为电化学传感器装置。 来自每个传感器单元的检测值通过电流放大器和/或差分放大器传输到计算机或计算器，用于与参考电极的电压的差分电压，以从检测值计算pH，压力或浓度，以及 数字显示在连接到计算机的显示设备上。

公开(公告)号：US08394247B2

公开(公告)日：2013-03-12

申请号：US12222900

申请日：2008-08-19

申请人： Masao Kamahori ,  Yu Ishige ,  Kotaro Yamashita ,  Yasuhisa Shibata ,  Masafumi Miyake ,  Kuniaki Nagamine

发明人： Masao Kamahori ,  Yu Ishige ,  Kotaro Yamashita ,  Yasuhisa Shibata ,  Masafumi Miyake ,  Kuniaki Nagamine

IPC分类号： G01N27/333

CPC分类号： G01N27/414 ,  G01N27/3335

摘要： The present invention aims to simplify the structure and a fabrication method of an ion-selective electrode in an ion concentration measuring device that measures an anion, particularly a chloride ion, in a biological component. To this end, in a potential difference measuring unit, a quaternary ammonium salt derivative serving as a ligand for an anion is immobilized to the surface of a gold electrode by using as a linker an insulative molecule forming a self-assembled monolayer. The potential difference measuring unit measures an electromotive force generated with anion binding, as an interface potential change on the surface of the gold electrode. In order to reduce the influence of adsorption of impurities on the electrode surface, a high-molecular weight polymer is physically adsorbed on the gold electrode and thus used when a biological component is measured.

公开(公告)号：US5344545A

公开(公告)日：1994-09-06

申请号：US817653

申请日：1992-01-07

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/28 ,  B01J19/00 ,  G01N27/404 ,  G01N27/49

CPC分类号： G01N27/404 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853

摘要： A gas sensor e.g. an oxygen sensor for testing body fluids, has a laminated structure with a cavity for holding a gel or liquid electrolyte in contact with a cathode and anodes formed by deposition on layers of the structure. The cathode contacts the electrolyte cavity only at a small-volume reaction region defined e.g. in a groove which communicates with a larger, laminar volume of the cavity formed e.g. by a spacer layer having through apertures. A small gas-permeable window opposes the cathode at the reaction region. The laminar construction can be mass-produced. The enlarged electrolyte reservoir lengthens the sensor life.

摘要翻译： 气体传感器 用于测试体液的氧传感器具有层压结构，其具有用于保持凝胶或液体电解质与阴极接触的空腔和通过沉积在该结构的层上形成的阳极。 阴极仅在限定的小体积反应区域处接触电解质腔。 在与形成的较大的层状体积的空腔连通的凹槽中。 通过具有通孔的间隔层。 小的透气窗在反应区域与阴极相对。 层状结构可以批量生产。 扩大的电解质储存器延长了传感器的使用寿命。

公开(公告)号：US08323468B2

公开(公告)日：2012-12-04

申请号：US12081736

申请日：2008-04-21

申请人： Masao Kamahori ,  Yu Ishige ,  Kotaro Yamashita ,  Yasuhisa Shibata ,  Masafumi Miyake

发明人： Masao Kamahori ,  Yu Ishige ,  Kotaro Yamashita ,  Yasuhisa Shibata ,  Masafumi Miyake

IPC分类号： G01N27/333

CPC分类号： G01N27/414

摘要： A crown ether derivative that acts as cation capturing ligand and alkanethiol having a longer carbon chain than a linker are immobilized, coexisting together, on the surface of a gold electrode, by using as the linker an insulating molecule (e.g., alkanethiol) that forms self-assembled monolayers. Electromotive force produced in association with cation coordination is measured by a potentiometer through a change in interfacial potential on the surface of the gold electrode. Further, an insulated gate field effect transistor formed on the same substrate as the gold electrode is used as the potentiometer. Furthermore, a straight-chain polymer physically adsorbed on the gold electrode is used in order to reduce the influence of the adsorption of impurities on the surface of the electrode during biological sample measurement.

摘要翻译： 作为阳离子捕获配体的冠醚衍生物和具有比接头长的碳链的链烷硫醇通过使用形成自身的绝缘分子（例如，链烷硫醇）固定在金电极的表面上并存在一起，在金电极的表面上共存 组合单层。 通过电极计通过金电极表面的界面电位的变化来测量与阳离子配位相关产生的电动势。 此外，与金电极形成在同一衬底上的绝缘栅场效应晶体管被用作电位计。 此外，使用物理吸附在金电极上的直链聚合物，以便在生物样品测量期间减少杂质在电极表面上的吸附的影响。

公开(公告)号：US07189315B2

公开(公告)日：2007-03-13

申请号：US10246458

申请日：2002-09-19

申请人： Kotaro Yamashita ,  Koichi Tayama ,  Noriko Yoshioka ,  Yasuhisa Shibata

发明人： Kotaro Yamashita ,  Koichi Tayama ,  Noriko Yoshioka ,  Yasuhisa Shibata

IPC分类号： C12Q1/68 ,  G01N27/26 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N27/3335 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/19 ,  Y10T436/193333

摘要： An ion sensor has a flow path through which a sample flows. An ion-exchange membrane is in contact with the sample in the sample flow path. An internal solution is provided on one side of the ion-exchange membrane. An internal electrode is provided so as to come in contact with the internal solution. The surface of the ion-exchange membrane that does not come in contact with the sample is coated with a two-liquid-mixed epoxy resin.

摘要翻译： 离子传感器具有样品流过的流路。 离子交换膜与样品流路中的样品接触。 在离子交换膜的一侧提供内部溶液。 设置内部电极以与内部溶液接触。 不与样品接触的离子交换膜的表面涂覆有双液混合环氧树脂。