公开(公告)号：US5352352A

公开(公告)日：1994-10-04

申请号：US948646

申请日：1992-09-23

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/404 ,  A61B5/00 ,  G01N27/49 ,  G01N33/49

CPC分类号： A61B5/14542 ,  A61B5/14539 ,  A61B5/1468 ,  G01N27/4045 ,  G01N33/4925

摘要： A sensor for detecting a carbonic acid gas dissolved in body fluids has a laminated structure including an outer plate having a carbonic acid gas permeable window, a plate for a pH-electrode having a pH sensitive membrane, an intermediate plate having a cavity for accommodating an electrolyte, and a plate for a reference electrode. The plate for the pH-electrode is constituted in a manner that a pH sensitive membrane constituted by a membrane of an oxide of a platinum group metal is formed on an insulating substrate and the electrolyte contacts with the pH sensitive membrane in a groove. The pH sensitive membrane is disposed so as to oppose to the carbonic acid gas permeable window.

摘要翻译： 用于检测溶解在体液中的碳酸气体的传感器具有包括具有碳酸气体透过窗的外板，具有pH敏感膜的pH电极的板，具有用于容纳 电解质和用于参考电极的板。 用于pH电极的板构成为在绝缘基板上形成由铂族金属的氧化物的膜构成的pH敏感膜，电解液与沟槽中的pH敏感膜接触。 将pH敏感膜设置成与碳酸气体透过窗口相对。

公开(公告)号：US5344545A

公开(公告)日：1994-09-06

申请号：US817653

申请日：1992-01-07

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/28 ,  B01J19/00 ,  G01N27/404 ,  G01N27/49

CPC分类号： G01N27/404 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853

摘要： A gas sensor e.g. an oxygen sensor for testing body fluids, has a laminated structure with a cavity for holding a gel or liquid electrolyte in contact with a cathode and anodes formed by deposition on layers of the structure. The cathode contacts the electrolyte cavity only at a small-volume reaction region defined e.g. in a groove which communicates with a larger, laminar volume of the cavity formed e.g. by a spacer layer having through apertures. A small gas-permeable window opposes the cathode at the reaction region. The laminar construction can be mass-produced. The enlarged electrolyte reservoir lengthens the sensor life.

摘要翻译： 气体传感器 用于测试体液的氧传感器具有层压结构，其具有用于保持凝胶或液体电解质与阴极接触的空腔和通过沉积在该结构的层上形成的阳极。 阴极仅在限定的小体积反应区域处接触电解质腔。 在与形成的较大的层状体积的空腔连通的凹槽中。 通过具有通孔的间隔层。 小的透气窗在反应区域与阴极相对。 层状结构可以批量生产。 扩大的电解质储存器延长了传感器的使用寿命。

公开(公告)号：US5250168A

公开(公告)日：1993-10-05

申请号：US723952

申请日：1991-07-01

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/28 ,  G01N27/26

CPC分类号： G01N27/414

摘要： Disclosed is an integrated ion sensor, which comprises at least one ion selective membrane sensitive to ions contained in a solution to be measured for detecting the concentration of the ions, a signal processing circuit for inputting a detected signal obtained by the ion selective membrane through a conductive member and fetching the detected signal through MOSFETs or the like included in an input stage to process the same, a reference electrode disposed in the measuring environment made by the solution to be measured and to be set to a predetermined voltage relationship between the reference electrode and the ion selective membrane, and a power supply having negative and positive terminals for supplying a driving power to the signal processing circuit through the terminals, one of the terminals being connected to the reference electrode, wherein the signal processing circuit is set to an active state at a voltage set to the reference electrode by controlling the threshold value of at least one of the MOSFETs of the signal processing circuit.

摘要翻译： 公开了一种集成离子传感器，其包括对待测溶液中包含的离子敏感的至少一种离子选择性膜，用于检测离子的浓度;信号处理电路，用于输入由离子选择性膜获得的检测信号通过 导电构件，并通过包含在输入级中的MOSFET等获取检测到的信号，以处理由待测量溶液制成的测量环境中的参考电极，并将其设置为参考电极之间的预定电压关系 和离子选择膜，以及具有用于通过端子向信号处理电路提供驱动电力的负极和正极端子的电源，其中一个端子连接到参考电极，其中信号处理电路被设置为有源 通过控制at的阈值将电压设置在参考电极的电压 信号处理电路中的至少一个MOSFET。

公开(公告)号：US5102525A

公开(公告)日：1992-04-07

申请号：US625014

申请日：1990-12-10

申请人： Yuji Miyahara ,  Keiji Tsukada ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

发明人： Yuji Miyahara ,  Keiji Tsukada ,  Yasuhisa Shibata ,  Hiroyuki Miyagi

IPC分类号： G01N27/404 ,  G01N27/49

CPC分类号： G01N27/404

摘要： A planar oxygen sensor has an insulating substrate, a cathode formed on the insulating substrate generally at the center thereof; another electrode formed on the insulating substrate in a region other than the region of the cathode, a gas permeable membrane stretched to cover these electrodes and having its peripheral portion supported on the insulating substrate, and an electrolytic solution charged between the gas permeable membrane and the insulating substrate. A surface of the cathode is substantially in contact with the gas permeable membrane and is formed at a position higher than the gas permeable membrane support portion of the insulating substrate. A portion of the insulating substrate surface other than the region where the cathode is formed is recessed. Because the layer of electrolytic solution on the cathode is thin, oxygen molecules passing through the gas permeable membrane can immediately serve for the reduction at the cathode, thereby increasing the response speed of the planar oxygen sensor. Also, the amount of electrolytic solution is increased by the recess to extend the life of the sensor.

公开(公告)号：US5132012A

公开(公告)日：1992-07-21

申请号：US369853

申请日：1989-06-22

申请人： Junkichi Miura ,  Andreas Manz ,  Yoshio Watanabe ,  Yuji Miyahara ,  Hiroyuki Miyagi ,  Keiji Tsukada

发明人： Junkichi Miura ,  Andreas Manz ,  Yoshio Watanabe ,  Yuji Miyahara ,  Hiroyuki Miyagi ,  Keiji Tsukada

IPC分类号： G01N30/18 ,  G01N30/32 ,  G01N30/38 ,  G01N30/60 ,  G01N30/64 ,  G01N35/00

CPC分类号： G01N30/6095 ,  G01N2030/385 ,  G01N2035/00237 ,  G01N30/18 ,  G01N30/32 ,  G01N30/64

摘要： A liquid chromatograph comprises an analyzing chip in which a capillary is formed in a substrate and a detector section is disposed downstream of the capillary. The capillary is covered so that an inlet opening end and an outlet opening end of said capillary flow path is opened. A frame member has a sample introduction path, a carrier liquid introduction path and a liquid discharge path. The analyzing chip is movably disposed in the frame member so that the inlet opening end and the outlet opening end of the capillary are selectively in communication with and/or under interruption against said sample introduction path, the carrier liquid introduction path and the liquid discharge path. The liquid chromatograph is very small in size but is easy to handle. Incidentally, there is disclosed also a sample introduction apparatus and method for the chromatograph, and an FET type detector suitable for the chromatograph.

摘要翻译： 液相色谱仪包括分析芯片，其中在基板中形成毛细管，并且检测器部分设置在毛细管的下游。 毛细管被覆盖，使得所述毛细管流路的入口开口端和出口开口端被打开。 框架构件具有样品引入路径，载液引入路径和液体排出路径。 分析芯片可移动地设置在框架构件中，使得毛细管的入口开口端和出口开口端选择性地与所述样品引入路径，载液引入路径和液体排出路径 。 液相色谱仪尺寸非常小，易于处理。 顺便提及，还公开了用于色谱仪的样品引入装置和方法，以及适用于色谱仪的FET型检测器。

公开(公告)号：US20070154077A1

公开(公告)日：2007-07-05

申请号：US11717667

申请日：2007-03-14

申请人： Kazuhisa Machida ,  Takafumi Kawasaki ,  Hiroyuki Suzuki ,  Keiji Tsukada

发明人： Kazuhisa Machida ,  Takafumi Kawasaki ,  Hiroyuki Suzuki ,  Keiji Tsukada

IPC分类号： G06K9/00

CPC分类号： A61B5/04007 ,  A61B5/7435 ,  A61B5/7445 ,  A61B2562/02 ,  A61B2562/046 ,  G01R33/10 ,  G06F19/00 ,  G16H40/63 ,  Y10S128/922

摘要： A display method for a magnetic field measuring apparatus which includes detecting a magnetic field generated from a biotest sample by a plurality of magnetic sensors and displaying measurement data obtained on the basis of the detected magnetic field in any display mode, which further comprises displaying an operating information display screen, the operating information display screen having a processing function display section selecting an operation menu including a biotest sample list, data measurement or data analysis; a biotest information display section; and a data display area.

摘要翻译： 一种磁场测量装置的显示方法，其包括通过多个磁传感器检测由生物体样本产生的磁场，并显示在任何显示模式下基于检测到的磁场获得的测量数据，其还包括显示操作 信息显示屏幕，具有处理功能显示部分的操作信息显示屏幕，其选择包括最终样品列表，数据测量或数据分析的操作菜单; 生物信息显示部分; 和数据显示区域。

公开(公告)号：US06681131B2

公开(公告)日：2004-01-20

申请号：US09977213

申请日：2001-10-16

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Daisuke Suzuki ,  Koichi Yokosawa ,  Keiji Tsukada

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Daisuke Suzuki ,  Koichi Yokosawa ,  Keiji Tsukada

IPC分类号： A61B505

CPC分类号： A61B5/04007 ,  A61B5/7239 ,  A61B5/7285

摘要： An apparatus for measuring bio-magnetic fields includes a plurality of magnetometers for detecting magnetic fields generated from a live body; a driving circuit for driving the magnetometers; a computer for collecting output signals of the driving circuit in the form of data representing at least one waveform of the magnetic fields generated from the live body and for performing an arithmetic processing on the data representing the waveform of magnetic fields, a display unit, and at least one signal processing circuit for processing output signals of the driving circuit. The computer further performs an arithmetic processing of first-order differentiation on the waveform of the magnetic fields in a z direction with respect to time in order to create an arrow map and a contour map. The apparatus can also detect mechanical movement which occurs as blood flows in organs and organs move.

摘要翻译： 一种用于测量生物磁场的装置包括：用于检测从活体产生的磁场的多个磁力计; 用于驱动磁力计的驱动电路; 用于以表示从活体产生的磁场的至少一个波形的数据形式收集驱动电路的输出信号并且对表示磁场波形的数据执行算术处理的计算机，显示单元和 至少一个信号处理电路，用于处理驱动电路的输出信号。 计算机进一步对z方向上的磁场波形进行一阶微分的运算处理，以便产生箭头图和轮廓图。 该装置还可以检测器官和器官中的血液流动时发生的机械运动。

公开(公告)号：US06665553B2

公开(公告)日：2003-12-16

申请号：US10120406

申请日：2002-04-12

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada ,  Masahiro Murakami

IPC分类号： A61B505

CPC分类号： A61B5/04009 ,  A61B5/04007 ,  A61B2562/02 ,  A61B2562/046 ,  G01R33/0354 ,  G06F19/00

摘要： A biomagnetic field measuring apparatus including: a plurality of magnetometers each employing a superconducting quantum interference device for measuring the magnetic field generated from an organism; a unit for calculating a pseudo-current from a normal component of the magnetic field; a unit for calculating the pseudo-current from the magnetic field obtained from the plurality of magnetometers to integrate the pseudo-current in a fixed direction on the circumference at a fixed distance from each of the associated ones of the sensors; a unit for calculating a maximum value or a minimum value of the integral value obtained by the unit for performing the integral; and a unit for calculating a difference value between the absolute value of the maximum value and the absolute value of the minimum value.

摘要翻译： 一种生物磁场测量装置，包括：多个磁力计，每个磁力计采用超导量子干涉装置来测量从生物体产生的磁场; 用于从磁场的正常分量计算伪电流的单元; 用于从所述多个磁力计获得的磁场计算所述伪电流以将固定方向上的所述伪电流与所述相关传感器中的每一个固定距离的圆周上积分的单元; 用于计算由用于执行积分的单元获得的积分值的最大值或最小值的单元; 以及用于计算最大值的绝对值和最小值的绝对值之间的差值的单元。

公开(公告)号：US06528994B2

公开(公告)日：2003-03-04

申请号：US09941752

申请日：2001-08-30

申请人： Daisuke Suzuki ,  Atsushi Ninomiya ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Keiji Tsukada ,  Koichi Yokosawa

发明人： Daisuke Suzuki ,  Atsushi Ninomiya ,  Tsuyoshi Miyashita ,  Akihiko Kandori ,  Keiji Tsukada ,  Koichi Yokosawa

IPC分类号： G01R3302

CPC分类号： G01R33/24

摘要： A magnetic field measuring apparatus has a magnetic field shielding apparatus including non-magnetic cylindrical members on which high-permeability sheets are located in a state of being partially overlapped with each other. The cylindrical members are located to surround an axis of a first direction concentrically and having a hollow portion, the cylindrical member located on an innermost-side having a first opening at one end of the first direction, a second opening at the other end of the first direction, and a third opening penetrating the cylindrical members in a direction perpendicular to the axis of the first direction. In addition, the magnetic field measuring apparatus has a living-body holder located in an inner-side space of the cylindrical member and a cryostat inserted into the third opening and maintaining SQUID magnetic-flux meters.

公开(公告)号：US06462540B1

公开(公告)日：2002-10-08

申请号：US09635450

申请日：2000-08-10

申请人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada

发明人： Akihiko Kandori ,  Tsuyoshi Miyashita ,  Keiji Tsukada

IPC分类号： G01R33035

CPC分类号： G01R33/025 ,  A61B5/0046 ,  A61B5/04005 ,  G01R33/0354 ,  Y10S505/846

摘要： A magnetic field measuring apparatus for precise cancellation of environmental noise includes a plurality of first SQUID gradiometers to detect noise and biomagnetic fields, a plurality of second SQUID gradiometers to detect noise, a driving circuit to drive these gradiometers, and a computer to execute signal processing after collecting the signals detected by these gradiometers. First and second SQUID gradiometers are provided which include first-order gradient pickup coils with the baselines formed by the coils of second gradiometers being shorter than those of first gradiometers. The apparatus cancels noise, from detected biomagnetic signal waveforms, caused by variant noise cancellation rates of the coils of first gradiometers, different baselines of the coils of second gradiometers, and the frequency property of a magnetically shielded room in which the apparatus is installed.

摘要翻译： 用于精确地消除环境噪声的磁场测量装置包括多个用于检测噪声和生物磁场的第一SQUID梯度计，用于检测噪声的多个第二SQUID梯度计，用于驱动这些梯度计的驱动电路以及计算机执行信号处理 收集这些梯度仪检测到的信号后。 提供了第一和第二SQUID梯度计，其包括一级梯度拾取线圈，其中由第二梯度仪的线圈形成的基线比第一梯度计的线圈短。 该装置从由第一梯度仪的线圈的不同噪声消除率，第二梯度仪的线圈的不同基线以及安装该装置的磁屏蔽室的频率特性引起的检测到的生物磁信号波形中消除噪声。