公开(公告)号：US06721915B2

公开(公告)日：2004-04-13

申请号：US09750098

申请日：2000-12-29

申请人： Satoshi Sato ,  Takeshi Furukawa ,  Akiko Matsumoto

发明人： Satoshi Sato ,  Takeshi Furukawa ,  Akiko Matsumoto

IPC分类号： G06F1100

CPC分类号： G11C29/10 ,  G11C29/56

摘要： In the case where the internal configuration is different in each memory (in the case where the correspondence information between the program address designated by the testing program and the physical address in the memory is different), the correspondence information of each memory is input from externally to the memory testing program, so that it becomes possible to use versatilely the memory testing program. Furthermore, even in the case where the internal configuration is unclear, it becomes possible to presume the internal configuration, so that it becomes possible to use versatilely the memory testing program for various memories.

摘要翻译： 在每个存储器内部配置不同的情况下（在由测试程序指定的程序地址与存储器中的物理地址之间的对应信息不同的情况下），每个存储器的对应信息从外部输入 到内存测试程序，使得可以通用的内存测试程序。 此外，即使在内部结构不清楚的情况下，也可以设定内部结构，从而可以通用地使用各种存储器的存储器测试程序。

公开(公告)号：US08407300B2

公开(公告)日：2013-03-26

申请号：US12399592

申请日：2009-03-06

申请人： Akiko Matsumoto

发明人： Akiko Matsumoto

IPC分类号： G06F15/16

CPC分类号： G06Q10/107

摘要： An address set in a forwarding mail of an electronic mail received from a sender is obtained, a receiver having a delete program for deleting the forwarding mail is identified as the obtained destination, and the electronic mail is related to the sender and the receiver of the identified delete program.

摘要翻译： 从发送者接收的电子邮件的转发邮件中设置的地址被确定为具有用于删除转发邮件的删除程序的接收者作为所获取的目的地，并且电子邮件与发送者和接收者有关 识别删除程序。

公开(公告)号：US20130095524A1

公开(公告)日：2013-04-18

申请号：US13704391

申请日：2011-06-16

申请人： Shigeyuki Yokoyama ,  Takahito Mukai ,  Kensaku Sakamoto ,  Akiko Matsumoto

发明人： Shigeyuki Yokoyama ,  Takahito Mukai ,  Kensaku Sakamoto ,  Akiko Matsumoto

IPC分类号： C12N15/70

CPC分类号： C12N15/70 ,  C07K14/245 ,  C12N9/93 ,  C12N15/11 ,  C12N15/67 ,  C12P21/02 ,  Y02P20/52

摘要： The present invention provides a novel method of producing a recombinant bacterium for production of a non-natural protein, including: (1) expressing tRNA in a bacterium, which tRNA recognizes UAG codon; (2) expressing an aminoacyl-tRNA synthetase in the bacterium, which aminoacyl-tRNA synthetase acylates the tRNA with a non-natural amino acid or an α-hydroxy acid; (3) (i) introducing a DNA construct into the bacterium, which DNA construct is for expressing, in the absence of a release factor for terminating translation at UAG codon, a function of at least one gene selected from the group consisting of genes each of which loses its function when a gene that codes for the release factor is defective and/or introducing an alteration into said at least one gene in a chromosome of the bacterium, which alteration is for expressing the function of said at least one gene in the absence of the release factor; and (4) causing the gene that codes for the release factor in the bacterium to be defective.

摘要翻译： 本发明提供了一种生产非天然蛋白质的重组细菌的新方法，包括：（1）在tRNA识别UAG密码子的细菌中表达tRNA; （2）在细菌中表达氨酰-tRNA合成酶，该氨基-tRNA合成酶用非天然氨基酸或α-羟基酸酰化tRNA; （3）（i）将DNA构建体引入细菌中，所述DNA构建体用于在不存在用于在UAG密码子下终止翻译的释放因子的情况下表达，所述DNA构建体用于表达至少一种选自下组的基因的功能： 当编码释放因子的基因有缺陷和/或引入细菌染色体中的所述至少一个基因的改变时，其失去功能，所述改变用于在所述细菌的染色体中表达所述至少一种基因的功能 不存在释放因子; 和（4）导致编码细菌释放因子的基因是有缺陷的。

公开(公告)号：US20080189275A1

公开(公告)日：2008-08-07

申请号：US12056587

申请日：2008-03-27

申请人： Akiko Matsumoto ,  Masahito Kobayashi

发明人： Akiko Matsumoto ,  Masahito Kobayashi

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： H04L51/066

摘要： A computer converts elements of a mail message, neither requiring prior manual registration of conversion process details, nor increasing complexity of the system. When a mail message arrives at this computer, an analysis record registration unit produces an analysis record that gives its sender's identifier and a source mailer type and stores it in an analysis record database. Based on the identifiers found in such analysis records, destination mailer type of each received mail message is determined. A conversion database stores conversion data specifying a conversion process corresponding to each specific combination of sender and recipient mailer types. A search unit retrieves conversion data that matches with the combination of source and destination mailer types of the received message. If a match is found for that combination, a converter converts the mail message according to a conversion process specified by the retrieved conversion data.

摘要翻译： 计算机转换邮件的元素，既不需要事先手动注册转换过程细节，也不会增加系统的复杂性。 当邮件消息到达该计算机时，分析记录注册单元产生分析记录，其给出其发送者的标识符和源邮件类型并将其存储在分析记录数据库中。 基于在这种分析记录中找到的标识符，确定每个接收到的邮件消息的目的地邮件类型。 转换数据库存储指定与发送方和接收方邮件类型的每个特定组合相对应的转换处理的转换数据。 搜索单元检索与接收到的消息的源和目的地邮件类型的组合匹配的转换数据。 如果找到该组合的匹配，则转换器根据所检索的转换数据指定的转换过程来转换邮件消息。

公开(公告)号：US09340790B2

公开(公告)日：2016-05-17

申请号：US13704391

申请日：2011-06-16

申请人： Shigeyuki Yokoyama ,  Takahito Mukai ,  Kensaku Sakamoto ,  Akiko Matsumoto

发明人： Shigeyuki Yokoyama ,  Takahito Mukai ,  Kensaku Sakamoto ,  Akiko Matsumoto

IPC分类号： C12N15/64 ,  C12N15/70 ,  C12N15/67 ,  C12P21/02 ,  C07K14/245 ,  C12N9/00 ,  C12N15/11

CPC分类号： C12N15/70 ,  C07K14/245 ,  C12N9/93 ,  C12N15/11 ,  C12N15/67 ,  C12P21/02 ,  Y02P20/52

摘要： The present invention provides a novel method of producing a recombinant bacterium for production of a non-natural protein, including: (1) expressing tRNA in a bacterium, which tRNA recognizes UAG codon; (2) expressing an aminoacyl-tRNA synthetase in the bacterium, which aminoacyl-tRNA synthetase acylates the tRNA with a non-natural amino acid or an α-hydroxy acid; (3) (i) introducing a DNA construct into the bacterium, which DNA construct is for expressing, in the absence of a release factor for terminating translation at UAG codon, a function of at least one gene selected from the group consisting of genes each of which loses its function when a gene that codes for the release factor is defective and/or introducing an alteration into said at least one gene in a chromosome of the bacterium, which alteration is for expressing the function of said at least one gene in the absence of the release factor; and (4) causing the gene that codes for the release factor in the bacterium to be defective.

摘要翻译： 本发明提供了一种生产非天然蛋白质的重组细菌的新方法，包括：（1）在tRNA识别UAG密码子的细菌中表达tRNA; （2）在细菌中表达氨酰-tRNA合成酶，该氨基-tRNA合成酶用非天然氨基酸或α-羟基酸酰化tRNA; （3）（i）将DNA构建体引入细菌中，所述DNA构建体用于在不存在用于在UAG密码子下终止翻译的释放因子的情况下表达，所述DNA构建体用于表达至少一种选自下组的基因的功能： 当编码释放因子的基因有缺陷和/或引入细菌染色体中的所述至少一个基因的改变时，其失去功能，所述改变用于在所述细菌的染色体中表达所述至少一种基因的功能 不存在释放因子; 和（4）导致编码细菌释放因子的基因是有缺陷的。

公开(公告)号：US5464910A

公开(公告)日：1995-11-07

申请号：US171681

申请日：1993-12-22

申请人： Takuo Nakatsuka ,  Tsuyoshi Toyota ,  Mie Tanimoto ,  Akiko Matsumoto

发明人： Takuo Nakatsuka ,  Tsuyoshi Toyota ,  Mie Tanimoto ,  Akiko Matsumoto

IPC分类号： C08G59/18 ,  C08F283/00

CPC分类号： C08G59/184 ,  C08G59/18 ,  Y10S525/936

摘要： An epoxy resin composition having high epoxy curing property and sufficient storage stability, and an epoxy curing agent therefor. The curing agent or the cure accelerating agent obtained by treating the surfaces of (1) an epoxy adduct obtained by adding a nitrogen-containing heterocyclic compound, an aliphatic amine or an aromatic amine to an epoxy compound having one, two or more epoxy groups in one molecule, with (2) a boric acid compound or (3) a boric acid compound and a phenolic compound, exhibits high curing property and storage stability, and can be favorably used as a curing agent for the epoxy resin composition. The epoxy resin composition prepared by mixing the epoxy resin with (1) and (2) or (1) and (3), exhibits excellent curing property and storage stability.

摘要翻译： 具有高环氧固化性和充分储存稳定性的环氧树脂组合物及其环氧固化剂。 通过将（1）通过将含氮杂环化合物，脂族胺或芳香胺加入到具有一个或多个环氧基的环氧化合物中获得的环氧加合物的表面处理得到的固化剂或固化促进剂， 一个分子与（2）硼酸化合物或（3）硼酸化合物和酚类化合物显示出高的固化性和储存稳定性，并且可以有利地用作环氧树脂组合物的固化剂。 通过将环氧树脂与（1）和（2）或（1）和（3）混合而制备的环氧树脂组合物表现出优异的固化性能和储存稳定性。

公开(公告)号：US20090298894A1

公开(公告)日：2009-12-03

申请号：US12426508

申请日：2009-04-20

申请人： Yutaka Ohmori ,  Takayuki Serizawa ,  Kazuteru Sugie ,  Kousuke Tanaka ,  Akiko Matsumoto

发明人： Yutaka Ohmori ,  Takayuki Serizawa ,  Kazuteru Sugie ,  Kousuke Tanaka ,  Akiko Matsumoto

IPC分类号： A61K31/4245 ,  C07D271/06 ,  A61P37/06

CPC分类号： C07D401/12 ,  C07D209/44 ,  C07D271/06 ,  C07D333/16 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

摘要： [Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to provide a pharmaceutical agent which comprises the compounds as an effective component, in particular to provide a therapeutic and/or prophylactic agent for an autoimmune disease and the like.[Solving Means] Amino acid compounds that are represented by the following Formula (1) are provided

摘要翻译： [问题]提供作为S1P1受体激动剂的新型化合物，并通过在二级淋巴组织中诱导淋巴细胞隔离来表现出免疫抑制活性。 此外，为了提供包含该化合物作为有效成分的药剂，特别是提供自身免疫性疾病等的治疗和/或预防剂。 [解决方案]提供由下式（1）表示的氨基酸化合物

公开(公告)号：US20090234929A1

公开(公告)日：2009-09-17

申请号：US12399592

申请日：2009-03-06

申请人： Akiko Matsumoto

发明人： Akiko Matsumoto

IPC分类号： G06F15/16

CPC分类号： G06Q10/107

摘要： An address set in a forwarding mail of an electronic mail received from a sender is obtained, a receiver having a delete program for deleting the forwarding mail is identified as the obtained destination, and the electronic mail is related to the sender and the receiver of the identified delete program.

摘要翻译： 从发送者接收的电子邮件的转发邮件中设置的地址被确定为具有用于删除转发邮件的删除程序的接收者作为所获取的目的地，并且电子邮件与发送者和接收者有关 识别删除程序。

公开(公告)号：US20090054401A1

公开(公告)日：2009-02-26

申请号：US11729795

申请日：2007-03-30

申请人： Akiko Matsumoto ,  Motoshi Shoda ,  Hiroshi Kuriyama

发明人： Akiko Matsumoto ,  Motoshi Shoda ,  Hiroshi Kuriyama

IPC分类号： A61K31/55 ,  C07C63/36 ,  A61K31/192 ,  A61K31/404 ,  C07D223/04 ,  C07D209/18 ,  C07D231/54 ,  A61K31/416

CPC分类号： C07D209/18 ,  C07C59/64 ,  C07C59/68 ,  C07C59/72 ,  C07C69/616 ,  C07C69/618 ,  C07C69/732 ,  C07C69/736 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2602/22 ,  C07D211/14 ,  C07D213/30 ,  C07D213/55 ,  C07D215/14 ,  C07D217/00 ,  C07D231/54 ,  C07D265/30 ,  C07D277/62 ,  C07D295/14 ,  C07D307/54 ,  C07D307/80 ,  C07D319/20 ,  C07D333/24 ,  C07D333/60 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10

摘要： [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action. [Means for Solution] A compound represented by the formula (I): [In the formula, represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V1 and V2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.

摘要翻译： 提供具有前列腺素生产抑制作用的化合物和白三烯生产抑制作用。 [解决方案]由式（I）表示的化合物：[式中，表示单键或双键，Link表示单键，或具有1或2个碳原子的饱和或不饱和直链烃， W表示单键，氧原子，硫原子，N（Rw）等，Rw表示氢原子，碳原子数为1〜8的烷基等，Rs表示-D-Rx等，D表示单键， 氧原子，硫原子等，Rx表示碳原子数为3〜8的直链或支链饱和烷基等，V1和V2之一表示Zx，另一个表示AR，Zx表示氢原子，直链或支链饱和 具有1〜4个碳原子的烷基等，AR表示部分不饱和或完全不饱和的稠合双环碳环或杂环，Y表示氢 原子，具有1至4个碳原子的低级烷基等]或其盐。