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    Use of lipid conjugates in the treatment of diseases
    1.
    发明授权
    Use of lipid conjugates in the treatment of diseases 有权

    公开(公告)号：US07101859B2

    公开(公告)日：2006-09-05

    申请号：US10627981

    申请日：2003-07-28

    申请人： Saul Yedgar ,  Miron Krimsky ,  Grietje Beck ,  Benito Antonio Yard ,  Fokko Johannes van der Woude

    发明人： Saul Yedgar ,  Miron Krimsky ,  Grietje Beck ,  Benito Antonio Yard ,  Fokko Johannes van der Woude

    IPC分类号： A61K31/70 ,  A61K31/175

    CPC分类号： A61K47/544

    摘要： The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels. The surprisingly manifold pharmacological properties of the PL-conjugates allow for the invention, disclosed herein, of novel methods for the treatment of a diverse range of disease states, including obstructive respiratory disease, including asthma; colitis and Crohn's disease; central nervous system insult, including blood brain barrier compromise, ischemic stroke, and multiple sclerosis; contact dermatitis; psoriasis; cardiovascular disease, including ischemic conditions and prophylaxis for invasive vascular procedures; cellular proliferative disorders, including anti-tumor vasculogenesis, invasiveness, and metastases; anti-oxidant therapy; hemolytic syndromes; sepsis; acute respiratory distress syndrome; tissue transplant rejection syndromes; autoimmune disease; viral infection; and hypersensitivity conjunctivitis. The therapeutic methods of the invention include administration of phosphatidylethanolamine bound to carboxymethylcellulose, heparin, hyaluronic acid, polyethylene glycol, and Polygeline (haemaccel). Disclosed herein are also new compounds comprised of phospholipid moieties bound to low molecular weight monomers and dimers, including mono- and disaccharides, carboxylated disaccharides, mono- and dicarboxylic acids, salicylates, bile acids, and fatty acids.

    Use of lipid conjugates in the treatment of disease
    2.
    发明授权
    Use of lipid conjugates in the treatment of disease 有权

    公开(公告)号：US07034006B2

    公开(公告)日：2006-04-25

    申请号：US09756765

    申请日：2001-01-10

    申请人： Saul Yedgar ,  David Shuseyov ,  Gershon Golomb ,  Reuven Reich ,  Isaac Ginsburg ,  Abd-al-Roof Higazi ,  Moshe Ligumski ,  Miron Krimsky ,  David Ojcius ,  Benito Antonio Yard ,  Fokko Johannes van der Woude ,  Edit Schnitzer

    发明人： Saul Yedgar ,  David Shuseyov ,  Gershon Golomb ,  Reuven Reich ,  Isaac Ginsburg ,  Abd-al-Roof Higazi ,  Moshe Ligumski ,  Miron Krimsky ,  David Ojcius ,  Benito Antonio Yard ,  Fokko Johannes van der Woude ,  Edit Schnitzer

    IPC分类号： A61K31/70 ,  A61K31/715 ,  C08B37/08 ,  C08B37/10 ,  C07H5/06

    CPC分类号： A61K47/544

    摘要： The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels. The surprisingly manifold pharmacological properties of the PL-conjugates allow for the invention, disclosed herein, of novel methods for the treatment of a diverse range of disease states, including obstructive respiratory disease, including asthma; colitis and Crohn's disease; central nervous system insult, including blood brain barrier compromise, ischemic stroke, and multiple sclerosis; contact dermatitis; psoriasis; cardiovascular disease, including ischemic conditions and prophylaxis for invasive vascular procedures; cellular proliferative disorders, including anti-tumor vasculogenesis, invasiveness, and metastases; anti-oxidant therapy; hemolytic syndromes; sepsis; acute respiratory distress syndrome; tissue transplant rejection syndromes; autoimmune disease; viral infection; and hypersensitivity conjunctivitis. The therapeutic methods of the invention include administration of phosphatidylethanolamine bound to carboxymethylcellulose, heparin, hyaluronic acid, polyethylene glycol, and hemaccel. Disclosed herein are also new compounds comprised of phospholipid moieties bound to low molecular weight monomers and dimers, including mono- and disaccharides, carboxylated disaccharides, mono- and dicarboxylic acids, salicylates, bile acids, and fatty acids.

    Use of lipid conjugates in the treatment of disease
    3.
    发明申请
    Use of lipid conjugates in the treatment of disease 有权
    使用脂质偶联物治疗疾病

    公开(公告)号：US20070078107A1

    公开(公告)日：2007-04-05

    申请号：US11524519

    申请日：2006-09-21

    申请人： Saul Yedgar ,  Miron Krimsky ,  Arie Ingber

    发明人： Saul Yedgar ,  Miron Krimsky ,  Arie Ingber

    IPC分类号： A61K31/737 ,  A61K31/728 ,  A61K31/717 ,  A61K31/727 ,  A61K31/685

    CPC分类号： A61K47/4823 ,  A61K31/661 ,  A61K31/685 ,  A61K31/717 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K47/61

    摘要： This invention provides a method of preventing or treating a dermatologic condition including, inter alia, psoriasis, contact dermatitis, and atopic dermatitis, in a subject, the method includes the step of administering to said subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.

    摘要翻译： 本发明提供了一种在受试者中预防或治疗皮肤病学疾病，包括牛皮癣，接触性皮炎和特应性皮炎的方法，所述方法包括向所述受试者施用包含脂质或磷脂部分结合的化合物的步骤 生理上可接受的单体，二聚体，低聚物或聚合物，和/或其药学上可接受的盐或其药物产品，其量有效地治疗患有皮肤病学病症的受试者。

    Use of lipid conjugates in the treatment of disease
    4.
    发明授权
    Use of lipid conjugates in the treatment of disease 有权
    使用脂质偶联物治疗疾病

    公开(公告)号：US08916539B2

    公开(公告)日：2014-12-23

    申请号：US11524519

    申请日：2006-09-21

    申请人： Saul Yedgar ,  Miron Krimsky ,  Arie Ingber

    发明人： Saul Yedgar ,  Miron Krimsky ,  Arie Ingber

    IPC分类号： A01N43/04 ,  A61K31/727 ,  A61K31/737 ,  A61K31/717 ,  A61K31/685 ,  A61K31/728

    CPC分类号： A61K47/4823 ,  A61K31/661 ,  A61K31/685 ,  A61K31/717 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K47/61

    摘要： This invention provides a method of preventing or treating a dermatologic condition including, inter alia, psoriasis, contact dermatitis, and atopic dermatitis, in a subject, the method includes the step of administering to said subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.

    摘要翻译： 本发明提供了一种在受试者中预防或治疗皮肤病学疾病，包括牛皮癣，接触性皮炎和特应性皮炎的方法，所述方法包括向所述受试者施用包含脂质或磷脂部分结合的化合物的步骤 生理上可接受的单体，二聚体，低聚物或聚合物，和/或其药学上可接受的盐或其药物产品，其量有效地治疗患有皮肤病学病症的受试者。

    Use of lipid conjugates in the treatment of diseases
    6.
    发明授权
    Use of lipid conjugates in the treatment of diseases 有权
    使用脂质偶联物治疗疾病

    公开(公告)号：US07141552B2

    公开(公告)日：2006-11-28

    申请号：US10790182

    申请日：2004-03-02

    申请人： Saul Yedgar ,  Moshe Ligumski ,  Miron Krimsky

    发明人： Saul Yedgar ,  Moshe Ligumski ,  Miron Krimsky

    IPC分类号： A61K38/00 ,  A61K42/00 ,  A61K9/127 ,  A61K31/715

    CPC分类号： C08B37/0072 ,  A61K47/544 ,  A61K47/61 ,  C07F9/10 ,  C07F9/117 ,  C08B11/12 ,  C08B31/12 ,  C08B37/0021 ,  C08B37/0069 ,  C08B37/0075 ,  C08B37/0084

    摘要： The invention provides a method for treating a subject suffering from an intestinal disease, including, inter alia, Crohn's disease, ulcerative colitis, immuno-inflammatory intestinal injury, drug-induced enteropathy and ischemia-induced intestinal injury. This invention further provides a pharmaceutical composition for treating a subject suffering from an intestinal disease, including, inter alia, a lipid or phospholipid moiety bonded to a physiologically acceptable monomer, dimer, oligomer, or polymer, and a pharmaceutically acceptable carrier or excipient.

    摘要翻译： 本发明提供一种治疗患有肠道疾病的受试者的方法，其特别包括克罗恩病，溃疡性结肠炎，免疫炎性肠损伤，药物诱导的肠病和缺血诱发的肠损伤。 本发明还提供了一种用于治疗患有肠道疾病的受试者的药物组合物，其特别包括与生理上可接受的单体，二聚体，低聚物或聚合物以及药学上可接受的载体或赋形剂结合的脂质或磷脂部分。

    Use of lipid conjugates in the treatment of diseases
    8.
    发明授权
    Use of lipid conjugates in the treatment of diseases 有权
    使用脂质偶联物治疗疾病

    公开(公告)号：US08383787B2

    公开(公告)日：2013-02-26

    申请号：US13031990

    申请日：2011-02-22

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： C07H5/04

    CPC分类号： C08B37/0069 ,  A61K31/728 ,  A61K31/737 ,  A61K47/544 ,  A61K47/61 ,  C08B37/0072

    摘要： This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.

    摘要翻译： 本发明提供由通式（A）的结构表示的化合物：其中L为脂质或磷脂，Z为无，乙醇胺，丝氨酸，肌醇，胆碱或甘油，Y为无或间隔基范围 长度为2至30个原子，X为生理上可接受的单体，二聚体，低聚物或聚合物，其中X为糖胺聚糖; n为1〜1000的数，L，Z，Y和X之间的任意键为酰胺键或酯键。

    USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES
    9.
    发明申请
    USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES 有权
    在治疗疾病中使用脂质偶联物

    公开(公告)号：US20100317591A1

    公开(公告)日：2010-12-16

    申请号：US12820161

    申请日：2010-06-22

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K31/726 ,  A61K31/728 ,  A61K31/737 ,  A61K31/727 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P29/00

    CPC分类号： A61K47/544

    摘要： This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.

    摘要翻译： 本发明提供了一种治疗患有皮肤病症状的个体的方法，其中包括尤其是牛皮癣，接触性皮炎和皮脂炎性皮炎，所述方法包括向受试者施用包含与 生理上可接受的单体，二聚体，低聚物或聚合物，和/或其药学上可接受的盐或其药物产品，其量有效地治疗患有皮肤病学病症的受试者。

    Use of lipid conjugates in the treatment of diseases
    10.
    发明申请
    Use of lipid conjugates in the treatment of diseases 失效
    使用脂质偶联物治疗疾病

    公开(公告)号：US20050203054A1

    公开(公告)日：2005-09-15

    申请号：US10952496

    申请日：2004-09-29

    申请人： Saul Yedgar

    发明人： Saul Yedgar

    IPC分类号： A61K31/685 ,  A61K31/715 ,  A61K31/727 ,  A61K31/737 ,  A61K31/739 ,  A61K38/16

    CPC分类号： A61K47/61 ,  A61K47/544

    摘要： This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.

    摘要翻译： 本发明提供由通式（A）的结构表示的化合物：其中L为脂质或磷脂，Z为无，乙醇胺，丝氨酸，肌醇，胆碱或甘油，Y为无或间隔基范围 长度为2至30个原子，X为生理上可接受的单体，二聚体，低聚物或聚合物，其中X为糖胺聚糖; n为1〜1000的数，L，Z，Y和X之间的任意键为酰胺键或酯键。