公开(公告)号：US10558029B2

公开(公告)日：2020-02-11

申请号：US15795150

申请日：2017-10-26

Applicant: Scopio Labs Ltd.

Inventor： Ben Leshem ,  Itai Hayut ,  Erez Na'Aman ,  Eran Small

IPC: G16H30/40 ,  G02B21/36 ,  G01N21/17 ,  G01N21/25 ,  G02B21/34 ,  G02B21/14

Abstract: Disclosed herein are systems and methods for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In some cases, a microscope may include an image capture device, an illumination assembly, and a processor configured to acquire a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and to reconstruct a high resolution image in response to the plurality of images. The disclosure also provides a method for generating a high resolution image of a sample comprising acquiring a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and reconstructing the high resolution image in response to the plurality of images.

公开(公告)号：US11650405B2

公开(公告)日：2023-05-16

申请号：US17098058

申请日：2020-11-13

Applicant: SCOPIO LABS LTD.

Inventor： Ben Leshem ,  Eran Small ,  Erez Na'aman ,  Ittai Madar

IPC: G02B21/00 ,  G02B21/34 ,  G02B21/06 ,  G02B21/36

CPC classification number: G02B21/006 ,  G02B21/06 ,  G02B21/34 ,  G02B21/367

Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.

公开(公告)号：US11482021B2

公开(公告)日：2022-10-25

申请号：US16851830

申请日：2020-04-17

Applicant: SCOPIO LABS LTD.

Inventor： Ben Leshem ,  Eran Small ,  Itai Hayut ,  Erez Na'Aman ,  Eyal Ben-Bassat

IPC: G06V20/69 ,  G01B11/06 ,  G01B11/22 ,  G01N21/25 ,  G06V10/56 ,  G06V10/141 ,  G06V20/64

Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.