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公开(公告)号：US11549955B2
公开(公告)日：2023-01-10
申请号：US16875665
申请日：2020-05-15
申请人： SCOPIO LABS LTD.
发明人： Itai Hayut , Erez Na'Aman , Eran Small
摘要： A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US10558029B2
公开(公告)日：2020-02-11
申请号：US15795150
申请日：2017-10-26
申请人： Scopio Labs Ltd.
发明人： Ben Leshem , Itai Hayut , Erez Na'Aman , Eran Small
摘要： Disclosed herein are systems and methods for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In some cases, a microscope may include an image capture device, an illumination assembly, and a processor configured to acquire a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and to reconstruct a high resolution image in response to the plurality of images. The disclosure also provides a method for generating a high resolution image of a sample comprising acquiring a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and reconstructing the high resolution image in response to the plurality of images.
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公开(公告)号：US20200041780A1
公开(公告)日：2020-02-06
申请号：US16338674
申请日：2017-10-26
申请人： SCOPIO LABS LTD.
发明人： Erez NA'AMAN , Michael Shimon ILUZ , Itai HAYUT
IPC分类号： G02B21/36 , G02B21/00 , G06T7/11 , G06F16/955
摘要： Access to microscope images while a sample is scanned or images are generated or uploaded can decrease an amount of time that a user waits to view a region of interest of an image. A processor can be configured to allow a remote user to access a portion of an image at full or partial resolution while other portions of the sample are being scanned, or while one or more images are generated or uploaded at full or partial resolution. A processor stored locally with the microscope can be configured to allow a remote user to access a completed scan over the internet prior to the scan being fully uploaded over a network such as the internet to a remote server. In some embodiments, a processor may be coupled to a microscope, a user device, or a remote server.
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公开(公告)号：US20230377144A1
公开(公告)日：2023-11-23
申请号：US18248553
申请日：2021-11-17
申请人： SCOPIO LABS LTD.
发明人： Ittai MADAR , Shahar KARNY , Eran SMALL , Erez NA'AMAN
CPC分类号： G06T7/0012 , G01N15/05 , G06T2207/10056 , G06T2207/30024 , G06T2207/30242 , G01N2015/055
摘要： A microscope system for detecting a scan area within hematology slides in digital microscopy may include a scanning apparatus to scan a hematology sample, and a processor coupled to the scanning apparatus and a memory. The processor may be configured to execute instructions which may cause the system to receive a first image of the sample at a first resolution and determine a scan area of the sample to scan in response to the first image. The instructions may further cause the system to scan the scan area to generate an image of the scan area at a second resolution greater than the first resolution and classify a plurality of cells from the image of the scan area into cell data comprising a plurality of cell parameters. The instructions may also cause the microscope system to output the cell data. Various other systems and methods are provided.
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公开(公告)号：US20210392304A1
公开(公告)日：2021-12-16
申请号：US17304331
申请日：2021-06-18
申请人： SCOPIO LABS LTD.
发明人： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
摘要： A microscope for computational imaging may include an illumination source configured to illuminate a sample with a plurality of wavelengths, an image sensor, an objective lens to image the sample onto the image sensor, and a processor operatively coupled to the illumination assembly and the image sensor. The processor may be configured to acquire a first image dataset from the sample illuminated using a first set of illumination conditions at a first wavelength. The processor may also be configured to acquire a second image dataset from the sample illuminated using a second set of illumination conditions having a second number of illumination conditions at a second wavelength. The second set of illumination conditions comprises fewer illumination conditions than the first set in order to decrease acquisition time. The processor may be configured to combine the first and second image datasets into a computationally reconstructed image of the sample.
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公开(公告)号：US20210149170A1
公开(公告)日：2021-05-20
申请号：US17098099
申请日：2020-11-13
申请人： SCOPIO LABS LTD.
发明人： Ben LESHEM , Eran SMALL , Erez NA'AMAN
摘要： A scanning microscope for z-stack acquisition may include, a stage to hold a sample, an illumination source to illuminate the sample, and an image capture device configured to capture multiple images of the sample within a field of view of the image capture device. The microscope may also include a lateral actuator for changing a relative lateral position between the image capture device and an imaged portion of the sample within the field of view of the image capture device for each of the images, and a focus actuator configured to adjust a focal distance between the sample and the image capture device between each of the images. The microscope may further include a processor connected to the lateral actuator and the focus actuator to move the sample laterally relative to the field of view and capture an area of the sample for each of multiple movement paths.
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公开(公告)号：US20200278530A1
公开(公告)日：2020-09-03
申请号：US16875721
申请日：2020-05-15
申请人： SCOPIO LABS LTD.
发明人： Ittai MADAR , Eran SMALL , Itai HAYUT , Erez NA'AMAN
摘要： A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.
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公开(公告)号：US20240085688A1
公开(公告)日：2024-03-14
申请号：US18514050
申请日：2023-11-20
申请人： SCOPIO LABS LTD.
发明人： Ittai MADAR , Eran SMALL , Itai HAYUT , Erez NA'AMAN
CPC分类号： G02B21/367 , G02B21/0084 , G02B21/125
摘要： A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.
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公开(公告)号：US20240060965A1
公开(公告)日：2024-02-22
申请号：US18235922
申请日：2023-08-21
发明人： Benzi KATZ , Irit AVIV , Shahar KARNY , Hadar SHIMONI , Amit NATAN , Ofek AIZENMAN
CPC分类号： G01N33/5094 , G01N1/30 , G01N2800/52
摘要： Methods of predicting the response of a subject to chimeric antigen receptor (CAR) therapy comprising receiving peripheral blood smears (PBS) from the subject and determining the number of CAR cells in the PBS are provided.
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公开(公告)号：US11650405B2
公开(公告)日：2023-05-16
申请号：US17098058
申请日：2020-11-13
申请人： SCOPIO LABS LTD.
发明人： Ben Leshem , Eran Small , Erez Na'aman , Ittai Madar
CPC分类号： G02B21/006 , G02B21/06 , G02B21/34 , G02B21/367
摘要： A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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