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公开(公告)号：US11549955B2
公开(公告)日：2023-01-10
申请号：US16875665
申请日：2020-05-15
Applicant: SCOPIO LABS LTD.
Inventor： Itai Hayut , Erez Na'Aman , Eran Small
Abstract: A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US10558029B2
公开(公告)日：2020-02-11
申请号：US15795150
申请日：2017-10-26
Applicant: Scopio Labs Ltd.
Inventor： Ben Leshem , Itai Hayut , Erez Na'Aman , Eran Small
Abstract: Disclosed herein are systems and methods for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In some cases, a microscope may include an image capture device, an illumination assembly, and a processor configured to acquire a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and to reconstruct a high resolution image in response to the plurality of images. The disclosure also provides a method for generating a high resolution image of a sample comprising acquiring a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and reconstructing the high resolution image in response to the plurality of images.
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公开(公告)号：US11650405B2
公开(公告)日：2023-05-16
申请号：US17098058
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben Leshem , Eran Small , Erez Na'aman , Ittai Madar
CPC classification number: G02B21/006 , G02B21/06 , G02B21/34 , G02B21/367
Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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Patent Agency Ranking
公开(公告)号：US11409095B2
公开(公告)日：2022-08-09
申请号：US16875721
申请日：2020-05-15
Applicant: SCOPIO LABS LTD.
Inventor： Ittai Madar , Eran Small , Itai Hayut , Erez Na'aman
Abstract: A microscope including an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample including artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that includes artifacts or empty space. The imaging process may include a higher resolution process to output higher resolution portions of the computational image for sample regions including valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions including valid sample material.
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公开(公告)号：US12061207B2
公开(公告)日：2024-08-13
申请号：US18063500
申请日：2022-12-08
Applicant: SCOPIO LABS LTD.
Inventor： Itai Hayut , Erez Na'aman , Eran Small
CPC classification number: G01N35/00029 , G02B21/34 , G01N2035/00039 , G01N2035/00089 , G02B21/002
Abstract: A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US11828927B2
公开(公告)日：2023-11-28
申请号：US17812374
申请日：2022-07-13
Applicant: SCOPIO LABS LTD.
Inventor： Ittai Madar , Eran Small , Itai Hayut , Erez Na'Aman
CPC classification number: G02B21/367 , G02B21/0084 , G02B21/125
Abstract: A microscope including an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample including artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that includes artifacts or empty space. The imaging process may include a higher resolution process to output higher resolution portions of the computational image for sample regions including valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions including valid sample material.
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公开(公告)号：US11482021B2
公开(公告)日：2022-10-25
申请号：US16851830
申请日：2020-04-17
Applicant: SCOPIO LABS LTD.
Inventor： Ben Leshem , Eran Small , Itai Hayut , Erez Na'Aman , Eyal Ben-Bassat
Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US10705326B2
公开(公告)日：2020-07-07
申请号：US15775370
申请日：2016-11-10
Applicant: Scopio Labs Ltd.
Inventor： Eran Small , Ittay Madar , Chen Brestel , Erez Naaman
IPC: G02B21/00 , G02B21/36 , G02B21/24 , G02B7/09 , G02B7/36 , G02B21/02 , G02B21/06 , G06K9/00 , H04N5/225
Abstract: Systems and methods are disclosed for focusing a microscope using images acquired under multiple illumination conditions. In one implementation, an autofocus microscope may include an image capture device, a focus actuator, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate a sample at a first illumination condition and at a second illumination condition. The controller may acquire a first image of the sample illuminated from the first illumination angle and a second image of the sample illuminated from the second illumination angle. The controller may further determine an amount of shift between image features present in the first image of the sample and a corresponding image features present in the second image of the sample, If the amount of determined shift is non-zero, the focus actuator may change the distance between the sample and the focal plane.
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