公开(公告)号：US06962791B2

公开(公告)日：2005-11-08

申请号：US09799608

申请日：2001-03-07

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N33/569 ,  A61K39/108 ,  A61K39/02

CPC分类号： A61K31/7004 ,  A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

公开(公告)号：US06420127B1

公开(公告)日：2002-07-16

申请号：US08640877

申请日：1996-10-10

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： G01N33569

CPC分类号： A61K31/7004 ,  A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

摘要翻译： 公开了用于治疗和/或预防由组织粘附细菌引起的疾病的新方法。 通过与周质分子伴侣相互作用，可以防止或抑制毛细血管的组装，从而减少细菌的感染性。 还公开了用于筛选药物的方法以及用于从头设计这些药物的方法，这些方法依赖于涉及大分子之间的结合自由能的近似计算的新型计算机药物建模方法。 最后，还公开了被认为能够与周质分子伴侣相互作用的新型吡喃糖苷。

公开(公告)号：US06548265B2

公开(公告)日：2003-04-15

申请号：US09799576

申请日：2001-03-07

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： G01N33569

CPC分类号： A61K31/7004 ,  A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

公开(公告)号：US07025971B2

公开(公告)日：2006-04-11

申请号：US09798932

申请日：2001-03-06

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： A61K39/10 ,  A61K39/02 ,  A61K39/108 ,  G01N33/569

CPC分类号： A61K31/7004 ,  A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

公开(公告)号：US06872542B1

公开(公告)日：2005-03-29

申请号：US09799584

申请日：2001-03-07

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N33/554 ,  A61K39/38 ,  A61K39/395 ,  A61K39/40 ,  A61K49/00

CPC分类号： G01N33/68 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7004 ,  C07H1/00 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

摘要翻译： 公开了用于治疗和/或预防由组织粘附细菌引起的疾病的新方法。 通过与周质分子伴侣相互作用，可以防止或抑制毛细血管的组装，从而减少细菌的感染性。 还公开了用于筛选药物的方法以及用于从头设计这些药物的方法，这些方法依赖于涉及大分子之间的结合自由能的近似计算的新型计算机药物建模方法。 最后，还公开了被认为能够与周质分子伴侣相互作用的新型吡喃糖苷。

公开(公告)号：US06596504B2

公开(公告)日：2003-07-22

申请号：US09799540

申请日：2001-03-07

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Charles Hal Jones ,  Jan Kihlberg

IPC分类号： A61K3902

CPC分类号： A61K31/7004 ,  A61K31/00 ,  A61K31/70 ,  C07H1/00 ,  G01N33/68 ,  G01N2333/195 ,  G01N2500/10 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

摘要翻译： 公开了用于治疗和/或预防由组织粘附细菌引起的疾病的新方法。 通过与周质分子伴侣相互作用，可以防止或抑制毛细血管的组装，从而减少细菌的感染性。 还公开了用于筛选药物的方法以及用于从头设计这些药物的方法，这些方法依赖于涉及大分子之间的结合自由能的近似计算的新型计算机药物建模方法。 最后，还公开了被认为能够与周质分子伴侣相互作用的新型吡喃糖苷。

公开(公告)号：US6153396A

公开(公告)日：2000-11-28

申请号：US465275

申请日：1995-06-05

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Jan Kihlberg ,  Charles Hal Jones

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Jan Kihlberg ,  Charles Hal Jones

IPC分类号： C12N15/09 ,  A61K31/165 ,  A61K31/18 ,  A61K31/43 ,  A61K31/545 ,  A61K31/65 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P31/04 ,  C07H1/00 ,  C07H5/06 ,  C07H15/04 ,  C07K5/06 ,  C07K9/00 ,  G01N33/569 ,  G01N33/68 ,  A61K39/02 ,  A61K39/108 ,  C12N1/00

CPC分类号： A61K31/7004 ,  C07H1/00 ,  G01N33/56911 ,  G01N33/68 ,  G01N2500/20 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

公开(公告)号：US6001823A

公开(公告)日：1999-12-14

申请号：US462436

申请日：1995-06-05

申请人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Jan Kihlberg ,  Charles Hal Jones

发明人： Scott Hultgren ,  Meta Kuehn ,  Zheng Xu ,  Derek Ogg ,  Mark Harris ,  Matti Lepisto ,  Jan Kihlberg ,  Charles Hal Jones

IPC分类号： C12N15/09 ,  A61K31/165 ,  A61K31/18 ,  A61K31/43 ,  A61K31/545 ,  A61K31/65 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P31/04 ,  C07H1/00 ,  C07H5/06 ,  C07H15/04 ,  C07K5/06 ,  C07K9/00 ,  G01N33/569 ,  G01N33/68 ,  A61K31/35 ,  C07D309/10

CPC分类号： A61K31/7004 ,  C07H1/00 ,  G01N33/56911 ,  G01N33/68 ,  G01N2500/20 ,  Y10S435/849

摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

公开(公告)号：US20090227516A1

公开(公告)日：2009-09-10

申请号：US12092724

申请日：2006-11-15

申请人： Rikard Holmdahl ,  Jan Kihlberg ,  Balik Dzhambazov ,  Mikael Vestberg

发明人： Rikard Holmdahl ,  Jan Kihlberg ,  Balik Dzhambazov ,  Mikael Vestberg

IPC分类号： A61K38/08 ,  C07K17/00 ,  A61P19/02

CPC分类号： A61K39/0008 ,  A61K47/6425 ,  A61K47/6811 ,  A61K47/6843 ,  A61K2039/605 ,  A61K2039/6056 ,  C07K7/08 ,  C07K14/4713 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/33

摘要： The invention relates a compound comprising (a) a peptide and (b) a carrier, wherein said peptide having at least the motif X-X-X-X-X-X-X, wherein at least one amino acid residue X is glycosylated, said peptide being linked to the peptide binding protein and said carrier comprises at least a MHC binding motif being linked to said peptide as well as pharmaceutical compositions comprising said compound and the use of said compound or pharmaceutical composition for the treatment of a disease, such as an inflammatory joint disease. The subject matter of the application is exemplified with peptides derived from type II collagen such as peptides having at least the sequence AGFKGEA, or IAGFKGEQPKG, or the peptide AAAKAAA. Preferably a hydroxylysine in the peptides are glycosylated.

摘要翻译： 本发明涉及包含（a）肽和（b）载体的化合物，其中所述肽至少具有基序XXXXXXX，其中至少一个氨基酸残基X被糖基化，所述肽与肽结合蛋白连接，所述肽 载体至少包含与所述肽连接的MHC结合基序以及包含所述化合物的药物组合物，以及所述化合物或药物组合物用于治疗疾病如炎性关节疾病的用途。 本申请的主题由来自II型胶原的肽例如至少具有AGFKGEA或IAGFKGEQPKG或肽AAAKAAA的肽示例。 优选地，肽中的羟赖氨酸是糖基化的。

公开(公告)号：US20070161545A1

公开(公告)日：2007-07-12

申请号：US11482553

申请日：2006-07-07

申请人： Rikard Holmdahl ,  Jan Engstrom ,  Jan Kihlberg ,  Harald Burkhardt

发明人： Rikard Holmdahl ,  Jan Engstrom ,  Jan Kihlberg ,  Harald Burkhardt

IPC分类号： A61K38/16 ,  A61K38/14 ,  A61K38/10

CPC分类号： C07K14/78 ,  A61K38/00 ,  G01N33/564 ,  G01N33/6881 ,  G01N2800/102 ,  G01N2800/24

摘要： The invention provides methods and materials related to treating and diagnosing autoimmune conditions. Specifically, the invention provides polypeptide compositions, nucleic acids, substantially pure polypeptides, host cells, and methods for identifying a mammal with an autoimmune condition, treating a mammal with an autoimmune condition, and enhancing tolerance in a mammal with an autoimmune condition.

摘要翻译： 本发明提供了治疗和诊断自身免疫病症的方法和材料。 具体地，本发明提供了多肽组合物，核酸，基本上纯的多肽，宿主细胞和用于鉴定具有自身免疫病症的哺乳动物的方法，用自身免疫病症治疗哺乳动物，以及增强具有自身免疫病症的哺乳动物的耐受性。