公开(公告)号：US20240254466A1

公开(公告)日：2024-08-01

申请号：US18612882

申请日：2024-03-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Ross WHITE ,  Sean HIGGINS ,  Sarah DENNY ,  Benjamin OAKES ,  Emeric Jean Marius CHARLES

IPC: C12N9/22 ,  C12N15/11 ,  C12N15/88

CPC classification number: C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N2310/20

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

公开(公告)号：US20240124537A1

公开(公告)日：2024-04-18

申请号：US18516722

申请日：2023-11-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Sean HIGGINS ,  Sarah DENNY ,  Ross WHITE ,  Emeric Jean Marius CHARLES ,  Addison WRIGHT ,  Benjamin DEMAREE ,  Manuel MOHR ,  Wenyuan ZHOU ,  Benjamin OAKES

IPC: C07K14/47 ,  C12N9/10 ,  C12N15/113

CPC classification number: C07K14/4703 ,  C12N9/1007 ,  C12N15/113 ,  C07K2319/09 ,  C07K2319/81 ,  C12N2310/20 ,  C12N2310/531

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

公开(公告)号：US20240392271A1

公开(公告)日：2024-11-28

申请号：US18693062

申请日：2022-09-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Ross WHITE ,  Sean HIGGINS ,  Sarah DENNY ,  Benjamin OAKES ,  Emeric Jean Marius CHARLES

IPC: C12N9/22 ,  A61K48/00 ,  C12N9/10 ,  C12N15/11 ,  C12N15/86 ,  C12N15/88 ,  C12N15/90

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

公开(公告)号：US20240123089A1

公开(公告)日：2024-04-18

申请号：US18516840

申请日：2023-11-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Sean HIGGINS ,  Sarah DENNY ,  Ross WHITE ,  Emeric Jean Marius CHARLES ,  Addison WRIGHT ,  Benjamin DEMAREE ,  Manuel MOHR ,  Wenyuan ZHOU ,  Benjamin OAKES

IPC: A61K48/00 ,  C12N9/10 ,  C12N9/22 ,  C12N15/113 ,  C12N15/88 ,  C12N15/90

CPC classification number: A61K48/005 ,  C12N9/1007 ,  C12N9/22 ,  C12N15/1137 ,  C12N15/88 ,  C12N15/907 ,  C12Y201/01037 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2310/531

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.