公开(公告)号：US20240392271A1

公开(公告)日：2024-11-28

申请号：US18693062

申请日：2022-09-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Ross WHITE ,  Sean HIGGINS ,  Sarah DENNY ,  Benjamin OAKES ,  Emeric Jean Marius CHARLES

IPC: C12N9/22 ,  A61K48/00 ,  C12N9/10 ,  C12N15/11 ,  C12N15/86 ,  C12N15/88 ,  C12N15/90

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

公开(公告)号：US20240123089A1

公开(公告)日：2024-04-18

申请号：US18516840

申请日：2023-11-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Sean HIGGINS ,  Sarah DENNY ,  Ross WHITE ,  Emeric Jean Marius CHARLES ,  Addison WRIGHT ,  Benjamin DEMAREE ,  Manuel MOHR ,  Wenyuan ZHOU ,  Benjamin OAKES

IPC: A61K48/00 ,  C12N9/10 ,  C12N9/22 ,  C12N15/113 ,  C12N15/88 ,  C12N15/90

CPC classification number: A61K48/005 ,  C12N9/1007 ,  C12N9/22 ,  C12N15/1137 ,  C12N15/88 ,  C12N15/907 ,  C12Y201/01037 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2310/531

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

公开(公告)号：US20240254466A1

公开(公告)日：2024-08-01

申请号：US18612882

申请日：2024-03-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Ross WHITE ,  Sean HIGGINS ,  Sarah DENNY ,  Benjamin OAKES ,  Emeric Jean Marius CHARLES

IPC: C12N9/22 ,  C12N15/11 ,  C12N15/88

CPC classification number: C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N2310/20

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

公开(公告)号：US20230183691A1

公开(公告)日：2023-06-15

申请号：US18164138

申请日：2023-02-03

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Sean HIGGINS ,  Isabel COLIN ,  Hannah SPINNER ,  Matthew GARDNER ,  Trent GOMBERG ,  Gayathri VIJAYAKUMAR ,  Sarah DENNY ,  Brett T. STAAHL ,  Maroof ADIL ,  Benjamin OAKES ,  Angus SIDORE ,  Suraj MAKHIJA

IPC: C12N15/11 ,  A61K9/00 ,  A61K9/50 ,  C07K14/005 ,  C12N9/22

CPC classification number: C12N15/111 ,  A61K9/0019 ,  A61K9/5052 ,  C07K14/005 ,  C12N9/22 ,  C12N2310/16 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32

Abstract: Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modification of nucleic acids in target cells. Also provided are methods of making and using such XDP to modify the nucleic acids in such cells.

公开(公告)号：US20240124537A1

公开(公告)日：2024-04-18

申请号：US18516722

申请日：2023-11-21

Applicant: Scribe Therapeutics Inc.

Inventor： Jason FERNANDES ,  Sean HIGGINS ,  Sarah DENNY ,  Ross WHITE ,  Emeric Jean Marius CHARLES ,  Addison WRIGHT ,  Benjamin DEMAREE ,  Manuel MOHR ,  Wenyuan ZHOU ,  Benjamin OAKES

IPC: C07K14/47 ,  C12N9/10 ,  C12N15/113

CPC classification number: C07K14/4703 ,  C12N9/1007 ,  C12N15/113 ,  C07K2319/09 ,  C07K2319/81 ,  C12N2310/20 ,  C12N2310/531

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.