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公开(公告)号：US07091041B2
公开(公告)日：2006-08-15
申请号：US10627247
申请日：2003-07-25
CPC分类号： A61K48/0025 , A61K9/1075
摘要： A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for easier delivery.
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公开(公告)号：US06897068B2
公开(公告)日：2005-05-24
申请号：US10085378
申请日：2002-02-27
申请人： Sean D. Monahan , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , DAvid B. Rozema , Paul M. Slattum
发明人： Sean D. Monahan , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , DAvid B. Rozema , Paul M. Slattum
CPC分类号： A61K48/0008 , A61K48/0041 , A61K48/0083
摘要： Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.
摘要翻译： 公开了用于在细胞中提供核酸表达的复合物。 将多核苷酸和聚合物混合在一起形成复合物，其中络合物的ζ电位不是正的。 然后将复合物递送到其中表达核酸的细胞。
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公开(公告)号：US06867196B1
公开(公告)日：2005-03-15
申请号：US09330909
申请日：1999-06-11
申请人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Jon A. Wolff , Hans Herweijer , Larry F. Whitesell , Matthew R. Wolff , Sean D. Monahan , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
CPC分类号： A61K48/0008 , A61K48/0075
摘要： A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.
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公开(公告)号：US06627616B2
公开(公告)日：2003-09-30
申请号：US09447966
申请日：1999-11-23
申请人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
发明人： Sean D. Monahan , Jon A. Wolff , Paul M. Slattum , James E. Hagstrom , Vladimir G. Budker , David B. Rozema
IPC分类号： C12N1500
CPC分类号： C12N15/113 , A61K31/70 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/62 , A61K47/6455 , A61K48/00 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C07H21/00 , C12N15/87 , C12N2320/32 , A61K2300/00
摘要： Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail vein or artery. Prior to insertion, subsequent to insertion, or concurrent with insertion the permeability of the vessel is increased thereby the genetic material is delivered to the parenchymal cell altering endogenous properties of the cell.
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公开(公告)号：US07396919B1
公开(公告)日：2008-07-08
申请号：US09328975
申请日：1999-06-09
申请人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
发明人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
摘要： An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
摘要翻译： 将离子聚合物用于“再充电”（具有不同电荷的另一层）缩合的多核苷酸复合物，用于向细胞递送核酸。 可以用合适量的正电荷或负电荷形成所得的再充电络合物，使得所得复合物具有所需的净电荷。
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公开(公告)号：US07098030B2
公开(公告)日：2006-08-29
申请号：US10899509
申请日：2004-07-26
申请人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
发明人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US20080234222A1
公开(公告)日：2008-09-25
申请号：US12132030
申请日：2008-06-03
申请人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
发明人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
IPC分类号： A61K31/70
摘要： An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
摘要翻译： 将离子聚合物用于“再充电”（具有不同电荷的另一层）缩合的多核苷酸复合物，用于向细胞递送核酸。 可以用合适量的正电荷或负电荷形成所得的再充电络合物，使得所得复合物具有所需的净电荷。
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8.发明授权公开(公告)号：US07482160B2
公开(公告)日：2009-01-27
申请号：US11322419
申请日：2005-12-30
申请人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
发明人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
IPC分类号： C12N15/88
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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公开(公告)号：US06673612B2
公开(公告)日：2004-01-06
申请号：US10081461
申请日：2002-02-21
IPC分类号： C12N1588
CPC分类号： A61K48/0025 , A61K9/1075
摘要： A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for easier delivery.
摘要翻译： 描述了可递送至细胞的复合物，包括将核酸或其他货物插入反胶束中。 反胶束具有压实核酸以便于递送的性质。
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公开(公告)号：US06429200B1
公开(公告)日：2002-08-06
申请号：US09354957
申请日：1999-07-16
IPC分类号： A61K317105
CPC分类号： A61K9/1075 , A61K48/0025
摘要： A complex is described for delivery to a cell comprising inserting a nucleic acid into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for easier delivery. Other molecules are used to interact with the nucleic acid—micelle complex to further enhance delivery such as a surfactant having a disulfide bond.
摘要翻译： 描述了一种复合物用于递送至包含将核酸插入反胶束中的细胞。 反胶束具有压实核酸以便于递送的性质。 使用其他分子与核酸 - 胶束复合物相互作用以进一步增强递送，例如具有二硫键的表面活性剂。
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