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72 条记录 (耗时 0.045 秒)

    MODEL DRIVEN CONNECTION APPROXIMATION FOR MECHANICAL, ELECTRICAL AND PLUMBING DRAWINGS
    5.
    发明申请
    MODEL DRIVEN CONNECTION APPROXIMATION FOR MECHANICAL, ELECTRICAL AND PLUMBING DRAWINGS 审中-公开
    机械，电气和配件图的驱动连接近似模型

    公开(公告)号：US20150286750A1

    公开(公告)日：2015-10-08

    申请号：US14407196

    申请日：2012-06-25

    申请人： Henry Chen ,  Geng Jian Du ,  Xiaoli Wang ,  Yan Xia ,  Liana Maria Kiff

    发明人： Henry Chen ,  Geng Jian Du ,  Xiaoli Wang ,  Yan Xia ,  Liana Maria Kiff

    IPC分类号： G06F17/50

    CPC分类号： G06F17/5004 ,  G06F17/509 ,  G06F2217/34 ,  G06K9/00476 ,  G06T7/001 ,  G06T2207/10004 ,  G06T2207/30108 ,  G06T2207/30176

    摘要： A system displays a raster-based or a vector-based formatted drawing on a user interface. A user selects a device on the drawing. The selected device is classified on a template. The drawing is searched for the classified template. Three-dimensional characteristics are imbued to the selected device. Connection types among different types of devices on the drawing are received into the system. A search is performed for all connection instances throughout the drawing using the received connection types. An object oriented and three-dimensionally, spatially referenced view of the drawing is generated on a user interface.

    摘要翻译： 系统在用户界面上显示基于栅格或基于矢量的格式化图形。 用户选择图纸上的设备。 所选设备分为模板。 搜索图纸的分类模板。 所选设备的三维特征。 图形中不同类型设备之间的连接类型被接收到系统中。 使用接收到的连接类型，对整个绘图中的所有连接实例执行搜索。 在用户界面上生成绘图的面向对象和三维空间参考视图。

    Bicyclic And Tricyclic Derivatives As Thrombin Receptor Antagonists
    8.
    发明申请
    Bicyclic And Tricyclic Derivatives As Thrombin Receptor Antagonists 有权
    双环和三环衍生物作为凝血酶受体拮抗剂

    公开(公告)号：US20080090830A1

    公开(公告)日：2008-04-17

    申请号：US11865793

    申请日：2007-10-02

    申请人： Samuel Chackalamannil ,  Mariappan Chelliah ,  Yuguang Wang ,  Yan Xia

    发明人： Samuel Chackalamannil ,  Mariappan Chelliah ,  Yuguang Wang ,  Yan Xia

    IPC分类号： A61K31/4427 ,  A61K31/435 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/502 ,  A61P1/00 ,  A61P11/00 ,  A61P15/00 ,  A61P17/00 ,  A61P35/00 ,  A61P9/00 ,  C07D221/06 ,  C07D401/06 ,  C07D413/02 ,  C07D487/00

    CPC分类号： C07D401/06 ,  C07D417/06

    摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bonds the dotted line is optionally a bond or no bonds resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failures and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

    摘要翻译： 异构体或外消旋混合物的下式的杂环取代三环或其药学上可接受的盐或溶剂合物，其中表示可选的双键，虚线可选地是一个键或没有导致双键或单键的键，如允许 通过化合价要求，其中E，A，GM，Het，B，X，R 3，R 10，R 11， 本文定义了SUP 32和33 SS，其余取代基如说明书中所定义，以及含有它们的药物组合物和治疗与血栓形成有关的疾病的方法 ，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心脏衰竭和癌症。 还要求与其它心血管药物联合治疗。

    Thrombin receptor antagonists
    9.
    发明授权
    Thrombin receptor antagonists 有权
    凝血酶受体拮抗剂

    公开(公告)号：US07304078B2

    公开(公告)日：2007-12-04

    申请号：US10412982

    申请日：2003-04-14

    申请人： Samuel Chackalamannil ,  William J. Greenlee ,  Yuguang Wang ,  Wenxue Wu ,  Enrico P. Veltri ,  Yan Xia

    发明人： Samuel Chackalamannil ,  William J. Greenlee ,  Yuguang Wang ,  Wenxue Wu ,  Enrico P. Veltri ,  Yan Xia

    IPC分类号： A61K31/443 ,  C07D405/02

    CPC分类号： C07D405/06 ,  C07D405/14 ,  C07D417/14

    摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt thereof, wherein: the dotted line represents an optional single bond; represents an optional double bond; n is 0–2; Q is cycloalkyl, optionally substituted by R13 and R14; R13 and R14 are independently selected from (C1–C6)alkyl, (C3–C8)cycloalkyl, —OH, (C1–C6)alkoxy, R27-aryl(C1–C6)alkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halogen and haloalkyl; or R13 and R14 together form a spirocyclic or a heterospirocyclic ring of 3–6 atoms; Het is a mono- or bi-cyclic optionally substituted heteroaryl group; and B is a bond, alkylene, or optionally substituted alkenylene or alkynylene, wherein the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

    摘要翻译： 式中的杂环取代三环

    Fused Ring Thrombin Receptor Antagonists
    10.
    发明申请
    Fused Ring Thrombin Receptor Antagonists 有权
    融合环凝血酶受体拮抗剂

    公开(公告)号：US20070244163A1

    公开(公告)日：2007-10-18

    申请号：US11734057

    申请日：2007-04-11

    申请人： Yan Xia ,  Mariappan V. Chelliah ,  Samuel Chackalamannil

    发明人： Yan Xia ,  Mariappan V. Chelliah ,  Samuel Chackalamannil

    IPC分类号： A61K31/4439 ,  C07D491/02

    CPC分类号： C07D405/06 ,  C07D498/04

    摘要： Fused-ring, heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, and wherein An, En, Mn, Gn, Jn, R3, n7, R8, R9, R10, R11, R32, R33, X, Y, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

    摘要翻译： 熔融环，具有下式的杂环取代的三环或所述化合物的药学上可接受的盐或溶剂合物，异构体或外消旋混合物，其中表示可选的双键，并且其中A N，N， M，N，N，N，N，N，N，N，N， R 8，R 9，R 10，R 11，R 32，R 12， 本文中定义了R32，X，Y，B和Het，其余取代基如说明书中所定义，以及含有它们的药物组合物和 通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病。 还要求与其它心血管药物联合治疗。