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22 条记录 (耗时 0.032 秒)

    Metal extrusion
    3.
    发明授权
    Metal extrusion 失效
    金属挤压

    公开(公告)号：US5309748A

    公开(公告)日：1994-05-10

    申请号：US836347

    申请日：1992-03-03

    申请人： Martin R. Jarrett ,  William Dixon

    发明人： Martin R. Jarrett ,  William Dixon

    IPC分类号： B21C23/00 ,  B21C23/01

    CPC分类号： B21C23/002 ,  B21C23/01 ,  Y10T428/12285

    摘要： A billet of extrudable metal, particularly an Al alloy is tapered at its back end. The billet is compressed longitudinally so that the metal of the tapered end is upset transversely. The compressed billet is hot extruded. The upsetting improves the fracture toughness of the back end of the extrusion. This is useful in long extrusions for the aircraft industry.

    摘要翻译： PCT No.PCT / GB90 / 01434 Sec。 371日期：1992年3月3日 102（e）1992年3月3日PCT PCT 1990年9月18日PCT公布。 出版物WO91 / 04110 日期1991年04月4日。可挤出金属坯料，特别是铝合金坯料在其后端是锥形的。 坯料被纵向压缩，使得锥形端部的金属横向受压。 压缩的坯料被热挤压。 镦粗改善了挤出后端的断裂韧性。 这对于飞机工业的长期挤压是有用的。

    Shoe holder adapters for stiff platform
    4.
    发明授权
    Shoe holder adapters for stiff platform 失效
    用于硬平台的鞋架适配器

    公开(公告)号：US4255822A

    公开(公告)日：1981-03-17

    申请号：US956128

    申请日：1978-10-30

    申请人： William Dixon

    发明人： William Dixon

    IPC分类号： A63B25/06 ,  A61F3/00

    CPC分类号： A63B25/06

    摘要： A shoe adapter for use for holding the user's shoe in fixed engagement with the shoe receiving stilt platforms of utility stilts, the shoe adapter including a frontal member fixedly secured to the stilt platform adapted to receive the frontal area of the user's shoe and including a heel member fixedly secured to the stilt platform in spaced relation with respect to the frontal member such that when the heel of the shoe of the user is placed within the heel member, the frontal area of the user's shoe will be locatable within the frontal member, the frontal member including a frontal base directly attached to the platform and a rigid upper member extending from one lateral end of the frontal base to the other lateral end of the frontal base to define a frontal shoe area receiving opening between the rigid upper member and the frontal base, the heel member including a heel base fixedly secured to the stilt platform, and at least two lateral heel plates extending upwardly from the lateral edges of the heel base to define a heel receiving means, the two lateral heel plates being alternatively inclined slightly inwardly to facilitate the retaining of the heel of the user's shoe in the adapter.

    摘要翻译： 一种鞋适配器，用于将用户的鞋子固定地接合到接收高跷高跷平台的鞋子，鞋子适配器包括固定地固定到踩平台的前部构件，其适于接收使用者鞋的前部区域，并且包括脚跟 构件相对于前部构件以间隔开的方式固定地固定到高跷平台，使得当使用者的鞋跟位于鞋跟构件内时，使用者的鞋的前部区域可位于前部构件内， 前部构件，其包括直接附接到平台的前部基部，以及刚性上部构件，其从前部基部的一个侧端延伸到前部基部的另一个侧端，以限定刚性上部构件和前部之间的前部鞋区域接收开口 所述脚跟部件包括固定在所述高跷平台上的脚跟基座以及从所述侧面向上延伸的至少两个侧向脚跟板 后跟基部的边缘以限定鞋跟接收装置，两个侧向脚跟板可选地倾斜向内倾斜，以便于使用者的鞋跟在适配器中的保持。

    Secure DNS query
    5.
    发明申请
    Secure DNS query 有权
    安全DNS查询

    公开(公告)号：US20090112814A1

    公开(公告)日：2009-04-30

    申请号：US11980928

    申请日：2007-10-31

    申请人： Jeromy S. Statia ,  Christopher J. Engdahl ,  Lee Walker ,  William Dixon

    发明人： Jeromy S. Statia ,  Christopher J. Engdahl ,  Lee Walker ,  William Dixon

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30864 ,  H04L29/12066 ,  H04L61/1511 ,  H04L61/6068 ,  H04L63/08

    摘要： A secure DNS query may be made by establishing a secure connection with a specific DNS server to determine an address for a hostname. A client device may have a database that may contain a record of a secure DNS server for one or more hostnames. When a DNS request contains one of the specified hostnames, an authenticated session may be created with the designated secure DNS server and a network address for the hostname is returned using the session. The authenticated session may authenticate a client device to the server as well as authenticate the server to the client. In some embodiments, the secure DNS server may accept connections from authenticated clients and may disregard connection requests from non authenticated clients.

    摘要翻译： 可以通过建立与特定DNS服务器的安全连接来确定主机名的地址来进行安全DNS查询。 客户端设备可以具有可以包含用于一个或多个主机名的安全DNS服务器的记录的数据库。 当DNS请求包含指定的主机名之一时，可以使用指定的安全DNS服务器创建经过身份验证的会话，并使用会话返回主机名的网络地址。 认证会话可以将客户端设备认证到服务器，并向服务器认证服务器。 在一些实施例中，安全DNS服务器可以接受来自经认证的客户端的连接，并且可以忽略来自未经认证的客户端的连接请求。

    Methods & Compositions For Enhancing Pharmaceutical Treatments
    6.
    发明申请
    Methods & Compositions For Enhancing Pharmaceutical Treatments 审中-公开
    用于增强药物治疗的方法和组合

    公开(公告)号：US20070203215A1

    公开(公告)日：2007-08-30

    申请号：US11627289

    申请日：2007-01-25

    申请人： Michael Newman ,  William Dixon

    发明人： Michael Newman ,  William Dixon

    IPC分类号： A61K31/417

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/417 ,  A61K45/06 ,  A61K2300/00

    摘要： Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

    摘要翻译： 提供了用于治疗和/或预防性治疗哺乳动物的改进方法，其中所述哺乳动物被保护免受活性药剂的毒性，所述活性药剂（i）与P-gp结合或是底物，（ii）是紫杉烷类似物和/ 或（iii）是微管蛋白分解的抑制剂。 另外提供了可用于治疗细胞增殖性疾病的组合物和方法。 还提供了增加哺乳动物中治疗和/或预防性治疗的生物利用度的方法。 具体实施方案涉及通过血脑屏障增加这种生物利用度。

    Method and framework for integrating a plurality of network policies
    8.
    发明申请
    Method and framework for integrating a plurality of network policies 有权

    公开(公告)号：US20070204154A1

    公开(公告)日：2007-08-30

    申请号：US11701153

    申请日：2007-02-01

    申请人： Brian Swander ,  William Dixon

    发明人： Brian Swander ,  William Dixon

    IPC分类号： H04L9/00

    CPC分类号： H04L63/0218 ,  H04L63/20

    摘要： A method and system is disclosed for managing and implementing a plurality of network policies in a network device. Each of the plurality of policies are defined by one or more filters. The filters are installed in a policy engine. A layer identifies the network policy to be applied to a packet by sending a request to the policy engine. The policy engine then returns the policy to the requesting layer. The method and system may be used to implement a programmable, host-based, distributed, authenticating firewall that enables security and other policies to be applied at several protocol layers.

    Nanoparticles with inorganic core and methods of using them
    9.
    发明申请
    Nanoparticles with inorganic core and methods of using them 审中-公开
    具有无机核的纳米颗粒及其使用方法

    公开(公告)号：US20060018835A1

    公开(公告)日：2006-01-26

    申请号：US10818235

    申请日：2004-04-02

    申请人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

    发明人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

    IPC分类号： A61K49/18 ,  A61K9/16 ,  A61K9/50

    CPC分类号： A61K49/1848 ,  A61K49/186 ,  B82Y5/00

    摘要： An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1 nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.

    摘要翻译： 本发明的一个方面包括纳米颗粒，其包括具有表面的基本上单分散的无机核，涂层基本覆盖基本上单分散的无机核的表面，其中该涂层至少包括涂层结构I，II或III，其中纳米颗粒是 基本上非聚集并且具有在约1nm至约100nm范围内的直径。 本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上 单分散无机芯，其中涂层包括涂层结构I，II或III。 本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法，包括基本上单分散的无机芯，其表面和基本覆盖基本上表面的涂层 单分散无机芯，其中涂层包括涂层结构I，II或III。

    Magnetic resonance imaging systems and methods for acquiring multi-slice gradient echo images
    10.
    发明授权
    Magnetic resonance imaging systems and methods for acquiring multi-slice gradient echo images 失效
    磁共振成像系统和获取多层梯度回波图像的方法

    公开(公告)号：US06914428B2

    公开(公告)日：2005-07-05

    申请号：US10219883

    申请日：2002-08-15

    申请人： William Dixon ,  Daniel Blezek ,  Paritosh Dhawale

    发明人： William Dixon ,  Daniel Blezek ,  Paritosh Dhawale

    IPC分类号： G01R33/54 ,  G01V3/00

    CPC分类号： G01R33/4835

    摘要： Magnetic resonance imaging (“MRI”) systems and methods for acquiring multi-slice gradient echo images having a substantially constant T1-weighting including selecting a first scan having a desired contrast associated with T1-weighting and, given a first repetition time, TR1, and a first flip angle, flip1, associated with the first scan, selecting an effective repetition time, TReff, that provides the desired contrast. The MRI systems and methods also including holding the effective repetition time, TReff, substantially constant in relation to a second scan. The MRI systems and methods further including, given a second repetition time, TR2, determining a second flip angle, flip2, and, given the second flip angle, flip2, determining the second repetition time, TR2. The MRI systems and methods still further including performing the second scan using the second repetition time, TR2, and the second flip angle, flip2, and maximizing a signal-to-noise ratio, S/N, of the second scan.

    摘要翻译： 磁共振成像（“MRI”）系统和方法，用于获取具有基本上恒定的T 1加权的多切片梯度回波图像，包括选择具有与T 1加权相关联的期望对比度的第一扫描，以及给定第一重复时间， TR 1和与第一次扫描相关联的第一翻盖1，选择提供期望对比度的有效重复时间TReff。 MRI系统和方法还包括保持有效重复时间TReff，相对于第二扫描基本上恒定。 MRI系统和方法进一步包括给定第二重复时间TR 2，确定第二翻转角翻转2，并且给定第二翻转角翻转2，确定第二重复时间TR 2。 MRI系统和方法还包括使用第二重复时间TR 2和第二翻转角翻转2执行第二次扫描，并且使第二次扫描的信噪比S / N最大化。