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公开(公告)号：US07070858B2
公开(公告)日：2006-07-04
申请号：US10630320
申请日：2003-07-30
CPC分类号： C08G63/64 , A61L17/12 , A61L31/06 , C08G63/08 , Y10T428/13 , Y10T428/139 , Y10T428/31504 , Y10T428/31786 , C08L67/04
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
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公开(公告)号：US06794485B2
公开(公告)日：2004-09-21
申请号：US10285040
申请日：2002-10-31
IPC分类号： C08G6308
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
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公开(公告)号：US20080302682A1
公开(公告)日：2008-12-11
申请号：US11761084
申请日：2007-06-11
申请人： Thomas Engstrom , Torbjorn Mathisen
发明人： Thomas Engstrom , Torbjorn Mathisen
IPC分类号： A24F23/02
CPC分类号： A24B13/00
摘要： A smokeless tobacco product adapted for oral administration includes a permeable pouch adapted for administration into a user's mouth and adapted to be removed from the mouth and disposed in nature and smokeless tobacco contained in the pouch. The pouch is made from a degradable polymer whose degradation properties allow the pouch to be essentially intact until the time of disposal and allow the pouch to degrade in nature after disposal.
摘要翻译： 适于口服给药的无烟烟草制品包括适于施用于使用者口中的可渗透小袋，并适于从口中移出并在自然界中放置并且包含在袋中的无烟烟草。 该袋由可降解的聚合物制成，其降解性质允许袋基本上完整，直到处理时间并且在处理后允许袋在性质上降解。
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公开(公告)号：US20080306494A1
公开(公告)日：2008-12-11
申请号：US11808563
申请日：2007-06-11
CPC分类号： A61F2/0063 , A61F2250/003 , D04B21/12
摘要： A resorbable polymeric mesh implant is provided for use in the reconstruction of soft tissue defects. The mesh implant is provided with an interlocking knitted structure comprising two or more sets of fibers with different times of degradation, allowing a stepwise increase in the relative distension of the overall mesh over time. The filamentous fibers are knitted together, wherein the filaments of the first set of fibers are interlaced into the filaments of the second set of fibers and at least partly traverse the knit pattern of the second set of fibers such that the filaments of the first set of fibers lock the movement of the part of the mesh formed by the second set of fibers.
摘要翻译： 提供可再吸收的聚合物网状植入物用于重建软组织缺陷。 网眼植入物具有互锁针织结构，其包括具有不同降解时间的两组或更多组纤维，允许随着时间的推移逐渐增加整个网状物的相对膨胀。 丝状纤维编织在一起，其中第一组纤维的长丝交织成第二组纤维的长丝，并且至少部分地横过第二组纤维的编织图案，使得第一组纤维的长丝 纤维锁定由第二组纤维形成的网的部分的运动。
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公开(公告)号：US20070299542A1
公开(公告)日：2007-12-27
申请号：US11472563
申请日：2006-06-22
IPC分类号： A61F2/02
CPC分类号： A61F2/0063
摘要： The present invention relates to a resorbable polymeric mesh implant, that is intended to be used in the reconstruction of soft tissue defects. The mesh implant comprises at least a first and a second material, wherein the second material is substantially degraded at a later point in time than the first material following the time of implantation. The mesh implant is adapted to have a predetermined modulus of elasticity that gradually is decreased until the mesh implant is completely degraded and subsequently resorbed. Due to the gradual decrease in the modulus of elasticity of the inventive mesh implant, the regenerating tissue may gradually take over the load applied to the tissue defect area.
摘要翻译： 本发明涉及可再吸收的聚合物网状植入物，其旨在用于重建软组织缺陷。 网状植入物包括至少第一和第二材料，其中在植入时间之后，第二材料在稍后的时间点比第一材料基本上劣化。 网状植入物适于具有逐渐降低的预定的弹性模量，直到网状植入完全降解并随后再吸收。 由于本发明的网状植入物的弹性模量的逐渐降低，再生组织可逐渐地承受施加于组织缺损区域的负荷。
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6.发明申请公开(公告)号：US20060205910A1
公开(公告)日：2006-09-14
申请号：US11076039
申请日：2005-03-10
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/4277 , C08G18/10 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, comprising in its hard blocks, at least two urea groups. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译： 线性聚脲聚氨酯聚合物本发明涉及一种在其硬块中包含至少两个脲基的线型聚脲氨酯聚合物。 优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。 聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。 本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应 溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。
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7.发明申请公开(公告)号：US20060211839A1
公开(公告)日：2006-09-21
申请号：US11356441
申请日：2006-02-17
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/10 , C08G18/4277 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, produced without the use of any chain extender. The hard block of the resulting polymer thus consists of diisocyante groups linked to each other via without the presence of any chain extender component. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译： 本发明涉及在不使用任何扩链剂的情况下生产的线型聚脲聚氨酯聚合物。 因此，所得聚合物的硬嵌段由相互连接的二异氰酸酯基组成，而不存在任何扩链剂组分。 优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。 聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。 本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应 溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。
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公开(公告)号：US20080196730A1
公开(公告)日：2008-08-21
申请号：US11571477
申请日：2005-06-08
申请人： Thomas Engstrom , Torbjorn Mathisen
发明人： Thomas Engstrom , Torbjorn Mathisen
IPC分类号： A24B15/00
CPC分类号： A61K9/0056 , A24B15/16 , A24B15/24 , A61K9/006 , A61K31/465
摘要： The present invention relates generally to a smokeless tobacco product in the form of a completely dissolvable vehicle (1; 11) comprising concentrated tobacco extract contained in a dissolvable matrix. In one embodiment, the vehicle (11) is a multilayer three-dimensional vehicle whose several layers (12, 13, 14) dissolve layer by layer in the mouth of a user.
摘要翻译： 本发明一般涉及一种完全可溶解的载体（1; 11）形式的无烟烟草制品，其包含含在可溶性基质中的浓缩烟草提取物。 在一个实施例中，车辆（11）是其多层（12,13,14）在使用者口中逐层溶解的多层三维车辆。
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公开(公告)号：US20060173492A1
公开(公告)日：2006-08-03
申请号：US10563024
申请日：2004-06-15
申请人： Dan Akerfeldt , Torbjorn Mathisen
发明人： Dan Akerfeldt , Torbjorn Mathisen
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/06166 , A61B2017/00659 , A61B2017/00884
摘要： The present invention relates to a sealing device (1; 11; 21; 31) for sealing a puncture in a vessel. The sealing device comprises a sealing element (2; 12; 22; 32) configured to be placed against a wall of the vessel and to seal the puncture in the vessel by contacting the vessel wall, and an elongated member (3; 13; 23; 33) connected to the sealing element and configured to extend in an incision canal leading to the puncture in the vessel. According to the invention, the elongated member, which can be in the form of a suture, filament, multifilament or a flexible stem, comprises a haemostatic material that stops or reduces secondary bleeding in the incision canal.
摘要翻译： 本发明涉及一种用于密封容器中的穿刺的密封装置（1; 11; 21; 31）。 所述密封装置包括密封元件（2; 12; 22; 32），所述密封元件被配置成抵靠所述容器的壁放置，并且通过使所述容器壁和所述细长构件（3; 13; 23 ; 33），其连接到所述密封元件并且构造成在切口中延伸，导致在所述容器中的穿刺。 根据本发明，可以是缝合线，细丝，复丝或柔性柄形式的细长构件包括停止或减少切口中的继发性出血的止血材料。
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10.发明授权Bioresorbable material and an article of manufacture made of such material for medical use 失效生物可再吸收材料和由这种用于医疗用途的材料制成的制品
公开(公告)号：US5525646A
公开(公告)日：1996-06-11
申请号：US108688
申请日：1993-09-03
申请人： Dan Lundgren , Jan Gottlow , Torbjorn Mathisen
发明人： Dan Lundgren , Jan Gottlow , Torbjorn Mathisen
IPC分类号： A61L17/00 , A61K6/00 , A61L27/00 , A61L27/18 , A61L27/50 , A61L31/00 , A61L31/06 , A61L31/14 , A61F2/00 , C08G63/91 , C08K5/10
CPC分类号： A61L31/141 , A61L27/18 , A61L27/502 , A61L31/06
摘要： This invention relates to a bioresorbable material and an article of manufacture of such material for medical use comprising homopolymers, copolymers, or a blend thereof selected from the group of monomers including glycolic acid, lactic acid, caprolactone, trimethylene carbonate, paradioxanone and 1,5 dioxepan-2-one, a plasticizer selected from the group including ethyl, butyl and hexyl esters of acetylated or non-acetylated citric acid, ethyl terminated oligomers of lactic acid, having no less than 2 and no more than 10 units, and lactic acid esters of glycerol, the material comprises 50% of amorphous polymer or polymers to impart to the material plastic malleability substantially without memory.
摘要翻译： PCT No.PCT / SE92 / 00139 Sec。 371日期1993年9月3日 102（e）日期1993年9月3日PCT 1991年3月4日PCT公布。 公开号WO92 / 15340 本发明涉及生物可吸收材料和用于医疗用途的这种材料的制造物，其包括均聚物，共聚物或其共混物，其选自包括乙醇酸，乳酸，己内酯，三亚甲基 碳酸酯，对二恶烷酮和1,5-二氧杂环庚烷-2-酮，选自乙酰化或非乙酰化柠檬酸的乙基，丁基和己基酯的增塑剂，具有不小于2且不大于2的乙酸封端的乳酸低聚物 超过10个单位和甘油的乳酸酯，该材料包含50％的无定形聚合物或聚合物，以基本上不记忆材料赋予材料塑性延展性。
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