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1.发明授权Compositions for inhibition of membrane fusion-associated events, including human parainfluenza virus transmission 失效用于抑制膜融合相关事件的组合物，包括人副流感病毒传播公开(公告)号：US06333395B1
公开(公告)日：2001-12-25
申请号：US08474349
申请日：1995-06-07
IPC分类号： C12N14115
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及显示出有力的抗逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID NO：1）肽以及DP178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。
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2.发明申请Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids 审中-公开编码DP-178的核酸和用于治疗辅助物质的其他病毒融合抑制剂肽公开(公告)号：US20070202127A1
公开(公告)日：2007-08-30
申请号：US11529806
申请日：2006-09-28
申请人： Dani Bolognesi , Thomas Matthews , Carl Wild , Shawn Barney , Dennis Lambert , Stephen Petteway , Alphonse Langlois
发明人： Dani Bolognesi , Thomas Matthews , Carl Wild , Shawn Barney , Dennis Lambert , Stephen Petteway , Alphonse Langlois
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/525 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/005 , C07K14/21 , C07K14/22 , C07K14/285 , C07K2319/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16222 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及显示出有力的抗逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1细胞gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽以及DP178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。
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3.发明申请Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission 审中-公开用于抑制膜融合相关事件（包括HIV传播）的方法和组合物公开(公告)号：US20070037141A1
公开(公告)日：2007-02-15
申请号：US10739355
申请日：2003-12-17
申请人： Darii Bolognesi , Thomas Matthews , Carl Wild , Shawn Barney , Dennis Lambert , Stephen Petteway , Alphonse Langlois
发明人： Darii Bolognesi , Thomas Matthews , Carl Wild , Shawn Barney , Dennis Lambert , Stephen Petteway , Alphonse Langlois
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及显示出有力的抗逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1细胞gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽以及DP178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。
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公开(公告)号：US20060161086A1
公开(公告)日：2006-07-20
申请号：US11299316
申请日：2005-12-09
申请人： Dennis Lambert
发明人： Dennis Lambert
IPC分类号： A61F5/00
CPC分类号： A61F5/3761 , A61H1/0274
摘要： An apparatus is shown for applying a traction force to a body member of a patient. The apparatus includes a columnar support coupling a lower arm to an upper arm. The columnar support has a fine adjustment mechanism for incrementally adjusting the distance between the lower arm and the upper arm along a central axis of the columnar support, wherein the distance corresponds to the traction force applied to the body member. The columnar support includes a plurality of sections that may be folded or separated for storage or transport. An attachment assembly, coupled to the upper arm, secures to one or more appendages in communication with the body member. A restraining element, coupled to the lower arm, secures to an opposing side of the body member such that the restraining element and the attachment assembly distribute the traction force to the body member upon actuation of the fine adjustment mechanism.
摘要翻译： 示出了用于将牵引力施加到患者的身体构件的装置。 该装置包括将下臂连接到上臂的柱状支撑。 柱状支撑件具有精细调节机构，用于沿着柱状支撑件的中心轴线逐渐调节下臂和上臂之间的距离，其中该距离对应于施加到主体构件的牵引力。 柱状支撑件包括可以折叠或分离以存储或运输的多个部分。 耦合到上臂的附接组件固定到与身体构件连通的一个或多个附件。 耦合到下臂的限制元件固定到本体构件的相对侧，使得约束元件和附接组件在微调机构致动时将牵引力分配到主体构件。
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