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公开(公告)号:US08188098B2
公开(公告)日:2012-05-29
申请号:US12433921
申请日:2009-05-01
申请人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20090286812A1
公开(公告)日:2009-11-19
申请号:US12433921
申请日:2009-05-01
申请人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A61K31/519 , C07D487/04 , A61P3/10
CPC分类号: C07D487/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US08987307B2
公开(公告)日:2015-03-24
申请号:US13406572
申请日:2012-02-28
申请人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号: A61K31/44 , C07D213/72 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
CPC分类号: C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
摘要: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译: 本发明涉及下式的新的3-氨基吡啶类,其中B1,B2和R1至R6如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂,可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号:US20120232051A1
公开(公告)日:2012-09-13
申请号:US13406572
申请日:2012-02-28
申请人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号: C07D213/72 , C07D401/04 , A61K31/496 , A61P3/10 , A61K31/444 , C07D413/12 , A61K31/5377 , A61K31/4427 , A61K31/4418 , A61K31/501
CPC分类号: C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
摘要: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译: 本发明涉及下式的新的3-氨基吡啶类,其中B1,B2和R1至R6如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂,可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号:US20120046306A1
公开(公告)日:2012-02-23
申请号:US13180775
申请日:2011-07-12
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Prabha Saba Karnachi , Jin-Jun Liu , Sung-Sau So , Jing Zhang , Zhuming Zhang
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Prabha Saba Karnachi , Jin-Jun Liu , Sung-Sau So , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/437 , C07D487/20 , A61P35/00 , A61K31/519 , A61K31/407 , C07D471/20 , C07D495/20
CPC分类号: C07D471/10 , C07D487/10 , C07D495/10
摘要: There are provided compounds of the general formula wherein A, B, V, W, R1, R2, R3, R3, and R4, are as described herein and enantiomers and pharmaceutically acceptable salts thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供了通式的化合物,其中A,B,V,W,R 1,R 2,R 3,R 3和R 4如本文所述,其对映异构体和药学上可接受的盐。 这些化合物可用作抗癌剂。
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