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    USER ANALYSIS THROUGH USER LOG FEATURE EXTRACTION
    1.
    发明申请
    USER ANALYSIS THROUGH USER LOG FEATURE EXTRACTION 审中-公开
    用户分析通过用户日志功能提取

    公开(公告)号：US20120278354A1

    公开(公告)日：2012-11-01

    申请号：US13097277

    申请日：2011-04-29

    申请人： Shengquan Yan ,  Zhenghao Wang ,  Xiao Huang ,  Yu Chen ,  An Yan ,  Jeffrey Eric Larsson ,  Michael Kiogora Kinoti ,  Peng Yu ,  Zijian Zheng

    发明人： Shengquan Yan ,  Zhenghao Wang ,  Xiao Huang ,  Yu Chen ,  An Yan ,  Jeffrey Eric Larsson ,  Michael Kiogora Kinoti ,  Peng Yu ,  Zijian Zheng

    IPC分类号： G06F17/30

    CPC分类号： G06Q10/063

    摘要： Systems, methods, and computer media for efficiently processing user log data are provided. A received user log data analysis request specifies: target user log features that identify users in a target user group, analysis user log features that identify data associated with the users in the target user group, and an analysis to perform on the identified data associated with the users in the target user group. Occurrences of specified features are extracted from user logs and stored. Users associated with an occurrence of each of the extracted and stored target user log features are identified as users in the target user group. Occurrences of the analysis user log features that are associated with a user in the target user group are extracted and reformatted for the analysis specified in the analysis request.

    摘要翻译： 提供了用于有效处理用户日志数据的系统，方法和计算机媒体。 接收到的用户日志数据分析请求指定：标识目标用户组中的用户的目标用户日志功能，分析用于识别与目标用户组中的用户相关联的数据的用户日志功能，以及对与 目标用户组中的用户。 指定功能的发生从用户日志中提取并存储。 与提取和存储的每个目标用户日志特征中的每一个相关联的用户被标识为目标用户组中的用户。 与目标用户组中的用户相关联的分析用户日志功能的出现被提取并重新格式化以用于分析请求中指定的分析。

    Monad based cloud computing
    2.
    发明授权
    Monad based cloud computing 有权
    基于Monad的云计算

    公开(公告)号：US08806451B2

    公开(公告)日：2014-08-12

    申请号：US13161787

    申请日：2011-06-16

    申请人： Zijian Zheng ,  Shengquan Yan ,  Peng Yu

    发明人： Zijian Zheng ,  Shengquan Yan ,  Peng Yu

    IPC分类号： G06F9/45 ,  G06F17/30 ,  G06F7/00 ,  G06F9/46

    CPC分类号： G06F17/30539

    摘要： Systems and methods are provided for using monads to facilitate complex computation tasks in a cloud computing environment. In particular, monads can be employed to facilitate creation and execution of data mining jobs for large data sets. Monads can allow for improved error handling for complex computation tasks. Monads can also facilitate identification of opportunities for improving the efficiency of complex computations.

    摘要翻译： 提供了系统和方法，以便在云计算环境中使用单极化来促进复杂的计算任务。 特别地，可以采用单子来促进大数据集的数据挖掘作业的创建和执行。 Monads可以允许改进复杂计算任务的错误处理。 Monads也可以促进识别提高复杂计算效率的机会。

    Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
    3.
    发明授权
    Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides 有权
    通过化学修饰实现蛋白质的位点特异性修饰，使蛋白质缀合物，蛋白质二聚体形成和装订肽

    公开(公告)号：US08927485B2

    公开(公告)日：2015-01-06

    申请号：US13030772

    申请日：2011-02-18

    申请人： Alexander Krantz ,  Peng Yu

    发明人： Alexander Krantz ,  Peng Yu

    IPC分类号： A61K38/00 ,  C07K16/00 ,  C07K17/00 ,  C07K17/14 ,  C12P21/08 ,  A61K38/24 ,  A61K38/27 ,  C07K1/00 ,  C07K14/00 ,  A61K47/48

    CPC分类号： A61K47/481 ,  A61K47/55

    摘要： The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

    摘要翻译： 本发明通常提供肽，多肽和蛋白质的位点特异性修饰的方法，例如粒细胞巨噬细胞集落刺激因子，人超氧化物歧化酶，膜联蛋白，瘦素，抗体等，细胞因子和趋化因子， 并且沿着蛋白质框架引入非天然氨基酸的位点。 本文所述的修饰可以用于加合物在放射性标记，分子成像和蛋白质治疗应用中的合成和应用，以及治疗疾病如类风湿性关节炎，红斑狼疮，牛皮癣，多发性硬化，1型糖尿病， 克罗恩病和系统性硬化症，阿尔茨海默病，癌症，肝病（如酒精性肝病）和恶病质。

    SITE-SPECIFIC MODIFICATION OF PROTEINS THROUGH CHEMICAL MODIFICATION ENABLING PROTEIN CONJUGATES, PROTEIN DIMER FORMATION, AND STAPLED PEPTIDES
    4.
    发明申请
    SITE-SPECIFIC MODIFICATION OF PROTEINS THROUGH CHEMICAL MODIFICATION ENABLING PROTEIN CONJUGATES, PROTEIN DIMER FORMATION, AND STAPLED PEPTIDES 有权
    通过化学修饰使蛋白质的蛋白质特异性修饰使蛋白质结合蛋白，蛋白质二聚体形成和嵌段蛋白

    公开(公告)号：US20110263832A1

    公开(公告)日：2011-10-27

    申请号：US13030772

    申请日：2011-02-18

    申请人： Alexander Krantz ,  Peng Yu

    发明人： Alexander Krantz ,  Peng Yu

    IPC分类号： C07K16/46 ,  C07K14/575

    CPC分类号： A61K47/481 ,  A61K47/55

    摘要： The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

    摘要翻译： 本发明通常提供肽，多肽和蛋白质的位点特异性修饰的方法，例如粒细胞巨噬细胞集落刺激因子，人超氧化物歧化酶，膜联蛋白，瘦素，抗体等，细胞因子和趋化因子， 并且沿着蛋白质框架引入非天然氨基酸的位点。 本文所述的修饰可以用于加合物在放射性标记，分子成像和蛋白质治疗应用中的合成和应用，以及治疗疾病如类风湿性关节炎，红斑狼疮，牛皮癣，多发性硬化，1型糖尿病， 克罗恩病和系统性硬化症，阿尔茨海默病，癌症，肝病（如酒精性肝病）和恶病质。

    INDEXING AND SEARCHING AUDIO USING TEXT INDEXERS
    5.
    发明申请
    INDEXING AND SEARCHING AUDIO USING TEXT INDEXERS 有权
    使用文本索引进行索引和搜索音频

    公开(公告)号：US20090150337A1

    公开(公告)日：2009-06-11

    申请号：US11952817

    申请日：2007-12-07

    申请人： Frank T.B. Seide ,  Peng Yu ,  Albert Joseph Kishan Thambiratnam

    发明人： Frank T.B. Seide ,  Peng Yu ,  Albert Joseph Kishan Thambiratnam

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30746 ,  G06F17/30778

    摘要： A full-text lattice indexing and searching system and method for indexing word lattices using a text indexer to enable enhance searching of audio content. The system and method utilize a Time-Anchored Lattice Expansion (TALE) method that represents word lattices such that they can be indexed with existing text indexers with little or no modification. Embodiments of system and method include an indexing module for generating and indexing word lattices based on audio content and a searching module for allowing searching of a full-text index containing indexed word lattices. The indexing module includes a custom IFilter and a custom Wordbreaker. Embodiments of the searching module include an ExpandQuery function for decorating an input query and a custom Stemmer. Embodiments of the searching module also include a GenerateSnippets module that extracts information from the indexed word lattices to enable the creation of clickable snippets.

    摘要翻译： 一种全文格式索引和搜索系统和方法，用于使用文本索引器索引字格，以增强对音频内容的搜索。 该系统和方法利用代表字格的时间锚定格子扩展（TALE）方法，使得它们可以用很少或没有修改的现有文本索引器进行索引。 系统和方法的实施例包括用于基于音频内容生成和索引字格的索引模块和用于允许搜索包含索引的字格的全文索引的搜索模块。 索引模块包括一个自定义的IFilter和一个自定义的Wordbreaker。 搜索模块的实施例包括用于装饰输入查询和定制Stemmer的ExpandQuery函数。 搜索模块的实施例还包括GenerateSnippets模块，该模块从索引的字格架提取信息，以创建可点击的片段。

    Process of oxidative conversion of methanol
    8.
    发明授权
    Process of oxidative conversion of methanol 有权
    甲醇的氧化转化过程

    公开(公告)号：US08476477B2

    公开(公告)日：2013-07-02

    申请号：US12713552

    申请日：2010-02-26

    申请人： Peng Yu ,  Jingsong Liu ,  Junfeng Rong ,  Changzhi Shi ,  Qiang Fu ,  Jin Wang ,  Wei Zhang ,  Xuhua Zhou

    发明人： Peng Yu ,  Jingsong Liu ,  Junfeng Rong ,  Changzhi Shi ,  Qiang Fu ,  Jin Wang ,  Wei Zhang ,  Xuhua Zhou

    IPC分类号： C07C41/50 ,  C07C43/315

    CPC分类号： B01J29/166 ,  B01J29/48 ,  B01J2229/20 ,  B01J2229/42 ,  C07C41/50 ,  C07C43/30

    摘要： A process for preparing polyoxymethylene dimethyl ethers from methanol is disclosed. For example, the process comprises contacting methanol with at least one oxidant in the presence of at least one catalyst wherein the at least one catalyst comprises at least one Group VIB metal component, such as in an amount of from about 0.5 to about 50 wt % (in terms of metal oxide) and at least one Group VIII metal component, such as in an amount of from about 0.2 to about 20 wt % (in terms of metal oxide), and at least one molecular sieve having acidic catalytic activity, such as in an amount of from about 40 to about 95 wt %, based on the total weight of the at least one catalyst for a time sufficient to obtain polyoxymethylene dimethyl ethers.

    摘要翻译： 公开了一种由甲醇制备聚甲醛二甲醚的方法。 例如，该方法包括在至少一种催化剂存在下使甲醇与至少一种氧化剂接触，其中至少一种催化剂包含至少一种VIB族金属组分，例如约0.5至约50重量％ （以金属氧化物计）和至少一种VIII族金属组分，例如约0.2至约20重量％（以金属氧化物计），和至少一种具有酸性催化活性的分子筛，例如 其量为约40至约95重量％，基于至少一种催化剂的总重量足以获得聚甲醛二甲醚的时间。

    Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation
    9.
    发明授权
    Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation 失效
    吡唑基苯基和LTA4H的吡咯基苯基抑制剂用于治疗炎症

    公开(公告)号：US08115005B2

    公开(公告)日：2012-02-14

    申请号：US11833313

    申请日：2007-08-03

    申请人： Vincent Sandanayaka ,  Jasbir Singh ,  Lei Zhao ,  Peng Yu ,  Mark E. Gurney

    发明人： Vincent Sandanayaka ,  Jasbir Singh ,  Lei Zhao ,  Peng Yu ,  Mark E. Gurney

    IPC分类号： C07D401/00 ,  A61K31/445

    CPC分类号： C07D231/12 ,  C07D207/325 ,  C07D207/333 ,  C07D207/34 ,  C07D231/14 ,  C07D231/16

    摘要： Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct bond, O, S, SO, SO2, NR1, CH2, CF2, and C(O); HET is a 4-7-membered saturated nitrogenous heterocycle; and taken together ZW is H or Z is (CH2)1-10 in which one or two (CH2) may optionally be replaced by —O—, —NR1—, —SO—, —S(O)2—, —C(═O)— or —C═O(NH)—; and W is hydrogen, acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl or substituted heterocyclyl. The compounds are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

    摘要翻译： 公开了吡唑基苯基和吡咯基苯基衍生物的两种化学属。 它们具有以下通式：在这些化合物中，环（a）是吡唑或吡咯; Q选自直接键O，S，SO，SO2，NR1，CH2，CF2和C（O）; HET是4-7元饱和含氮杂环; 并且一起ZW是H或Z是（CH 2）1-10，其中一个或两个（CH 2）可以任选地被-O-，-NR1-，-SO-，-S（O）2 - ， - C （= O） - 或-C = O（NH） - ; W是氢，酰基，羟基，羧基，氨基，甲酰胺基，氨基酰基，-COO烷基，-CHO，杂环基，取代的芳基或取代的杂环基。 这些化合物是LTA4H（白三烯A4水解酶）的抑制剂。 它们可用于治疗和预防和预防炎性疾病和病症。