公开(公告)号：US09126983B2

公开(公告)日：2015-09-08

申请号：US13518613

申请日：2010-12-17

申请人： Sheo Singh ,  Jon D. Polishook ,  Deborah L. Zink ,  Olga Genilloud ,  Michael Goetz ,  Francisca Vicente ,  David Brian Olsen ,  Scott Knoble Smith

发明人： Sheo Singh ,  Jon D. Polishook ,  Deborah L. Zink ,  Olga Genilloud ,  Michael Goetz ,  Francisca Vicente ,  David Brian Olsen ,  Scott Knoble Smith

IPC分类号： C07H15/26 ,  A61P31/04 ,  A61K31/706 ,  A61K31/7056 ,  A01N43/86 ,  A01N43/36 ,  C07D407/14 ,  A61K31/535 ,  A61K31/4025 ,  C07D413/14 ,  C12P17/16 ,  C12R1/01

CPC分类号： C07D407/14 ,  A01N43/36 ,  A01N43/86 ,  A61K31/4025 ,  A61K31/535 ,  C07D413/14 ,  C12P17/16 ,  C12R1/01 ,  Y02A50/473

摘要： The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.

摘要翻译： 本发明涉及可用于治疗和/或预防人和动物细菌感染和相关疾病和病症的式（I）和（II）的新化合物及其药学上可接受的盐; 含有这些化合物的组合物; 通过发酵和分离，部分合成和总合成衍生这些化合物; 抑制细菌生长的方法 治疗，预防或控制细菌感染的方法; 细菌菌株的生物纯培养物可从其中产生这些化合物; 以及制备含有这些化合物的组合物的方法。

公开(公告)号：US20130005673A1

公开(公告)日：2013-01-03

申请号：US13518613

申请日：2010-12-17

申请人： Sheo Singh ,  Jon D. Polishook ,  Deborah L. Zink ,  Olga Genilloud ,  Michael Goetz ,  Francisca Vicente ,  David Brian Olsen ,  Scott Knoble Smith

发明人： Sheo Singh ,  Jon D. Polishook ,  Deborah L. Zink ,  Olga Genilloud ,  Michael Goetz ,  Francisca Vicente ,  David Brian Olsen ,  Scott Knoble Smith

IPC分类号： C07H15/26 ,  C12P19/46 ,  A61P31/04 ,  C12N1/20 ,  A61K31/706 ,  A61K31/7056

CPC分类号： C07D407/14 ,  A01N43/36 ,  A01N43/86 ,  A61K31/4025 ,  A61K31/535 ,  C07D413/14 ,  C12P17/16 ,  C12R1/01 ,  Y02A50/473

摘要： The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.

摘要翻译： 本发明涉及可用于治疗和/或预防人和动物细菌感染和相关疾病和病症的式（I）和（II）的新化合物及其药学上可接受的盐; 含有这些化合物的组合物; 通过发酵和分离，部分合成和总合成衍生这些化合物; 抑制细菌生长的方法 治疗，预防或控制细菌感染的方法; 细菌菌株的生物纯培养物可从其中产生这些化合物; 以及制备含有这些化合物的组合物的方法。