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公开(公告)号：US5290772A
公开(公告)日：1994-03-01
申请号：US899235
申请日：1992-06-16
CPC分类号： C12R1/01 , C07H19/01 , C12P17/188
摘要： Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism, Actinoplanacete sp, (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了在使用微生物Actinoplanacete sp（Merck Culture Collection MA 6559）ATCC No.53771的发酵条件下生产免疫抑制剂“demethimmunomycin”（L-683,71411）L-683,590的C-31去甲基化类似物的方法 大环内酯类免疫抑制剂可用于预防外来器官移植的人宿主排斥反应 骨髓和心脏移植。
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公开(公告)号：US5268370A
公开(公告)日：1993-12-07
申请号：US872741
申请日：1992-04-22
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18 , C12P19/44 , A61K31/33 , C07D498/16
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/445
摘要： Described is a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, (FK-506) produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的免疫抑制剂L-683,519，L-679,934的单甲基化重排的衍生物（FK-506），其在使用微生物，不明的放线菌（Merck Culture Collection MA 6474）ATCC No.58288的发酵条件下产生。大环内酯类免疫抑制剂是 可用于预防人体宿主排斥外来器官移植物，例如 骨髓和心脏移植。
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公开(公告)号：US4981792A
公开(公告)日：1991-01-01
申请号：US213063
申请日：1988-06-29
IPC分类号： A61K31/395 , A61K35/74 , A61P37/06 , C07D213/50 , C07D213/79 , C07D493/18 , C07D498/18 , C07G99/00 , C07H19/01 , C12P17/18 , C12R1/01
CPC分类号： C07D493/18 , C07H19/01 , C12P17/18 , Y10S435/827
摘要： Described is a process for producing a new immunosuppressant, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in prevent human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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公开(公告)号：US5202258A
公开(公告)日：1993-04-13
申请号：US847873
申请日：1992-03-09
申请人： Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Edward S. Inamine , Sagrario Mochales , Linda S. Wicker
发明人： Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Edward S. Inamine , Sagrario Mochales , Linda S. Wicker
CPC分类号： C12R1/045 , Y10S436/827
摘要： Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的微生物Actinoplanacete sp。（Merck Culture Collection MA 6559）ATCC No.53771.微生物作为去甲基化剂，可以产生新的免疫抑制剂“吗啡霉素”（L-682,993）C-31去甲基化的类似物 的L-679,934和“demethimmunomycin”（L-683,742）L-683,590的C-31去甲基化类似物，在新的发酵条件下。 这些大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥反应。 骨髓和心脏移植。
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公开(公告)号：US5138052A
公开(公告)日：1992-08-11
申请号：US666466
申请日：1991-03-05
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188
摘要： Described is a new L-679,934 (FK-506) antagonist, L-686,292, a C-15, C-31 bisdemethylated, derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide reverses the immunosuppressant action of L-679,934 (FK-506), and can be used diagnostically as a tool to determine the presence of FK-506 macrolide type immunosuppressants in natural product broths, distinguishing such immunosuppressants from other chemical families such as the cycloporins.
摘要翻译： 描述了一种新的L-679,934（FK-506）拮抗剂L-686,292，C-15，C-31双脱甲基化的L-683,590衍生物，其在使用微生物Actinoplanacete sp。 （Merck Culture Collection MA 6559）ATCC编号53771.大环内酯可逆转L-679,934（FK-506）的免疫抑制剂作用，可用于诊断上用于确定天然产物中FK-506大环内酯型免疫抑制剂的存在 肉汤，区分这些免疫抑制剂与其他化学家族如环保蛋白。
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公开(公告)号：US4975372A
公开(公告)日：1990-12-04
申请号：US297631
申请日：1989-01-13
IPC分类号： C12P17/18 , A61K31/445 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , C07D498/18 , C07H19/01 , C12P1/06 , C12R1/01
CPC分类号： C07D498/18 , C07H19/01 , C12P1/06 , Y10S435/826
摘要： Described is a new immunosuppressant, L-685,487, a monodemethylated rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Cultrue Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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公开(公告)号：US5270187A
公开(公告)日：1993-12-14
申请号：US824690
申请日：1992-01-21
CPC分类号： C12P17/188 , Y10S435/827 , Y10S435/886
摘要： Described is a process for producing a new immunosuppressant, L-682,992, a C-13, C-31 demethylated ring-rearranged analog of L-679,934, under novel fermentation conditions utilizing the microorganism, Actinoplanacete Sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了在使用微生物Actinoplanacete Sp。（Merck Culture Collection MA 6559）的新型发酵条件下生产新的免疫抑制剂L-682,992，C-13，C-31脱甲基环重排的L-679,934类似物的方法 ）ATCC No.53771.大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥，例如 骨髓和心脏移植。
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公开(公告)号：US5252612A
公开(公告)日：1993-10-12
申请号：US905075
申请日：1992-06-24
IPC分类号： C07D498/18 , C07H19/01 , C12P1/06 , A61K35/00
CPC分类号： C07D498/18 , C07H19/01 , C12P1/06
摘要： Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的免疫抑制剂L-683,756，L-683,590的双脱甲基化环重排衍生物，其在使用微生物Actinoplanacete sp。 （Merck Culture Collection MA 6559）ATCC No.53771.大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥反应。 骨髓和心脏移植。
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公开(公告)号：US4987139A
公开(公告)日：1991-01-22
申请号：US348243
申请日：1989-05-05
IPC分类号： C12Q1/02 , C07D498/18 , C07G99/00 , C12P17/18
CPC分类号： C12P17/188
摘要： Described is a new immunosuppressant, L-687,795, a C-13, C-15, C-31 trisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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10.发明授权Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors 失效链霉菌属 用于微生物合成HIV蛋白酶抑制剂的MA 7074（ATCC 55605）
公开(公告)号：US5612217A
公开(公告)日：1997-03-18
申请号：US328221
申请日：1994-10-25
申请人： Ali Shafiee , Shieh-Shung T. Chen , Byron H. Arison , Randall R. Miller , George M. Garrity , Brian Heimbuch
发明人： Ali Shafiee , Shieh-Shung T. Chen , Byron H. Arison , Randall R. Miller , George M. Garrity , Brian Heimbuch
IPC分类号： C12P17/16 , A61K31/495 , A61P31/12 , A61P37/04 , C07D401/06 , C12N1/20 , C12N7/00 , C12R1/465
CPC分类号： C07D401/06 , Y10S435/886
摘要： Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 具有培养物MA7074的发酵的生物转化产物是有效的HIV蛋白酶抑制剂。 这些产品可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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