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公开(公告)号:US06423037B1
公开(公告)日:2002-07-23
申请号:US09555252
申请日:2000-05-26
IPC分类号: A61M500
CPC分类号: A61M5/24 , A61M5/178 , A61M5/2448 , A61M2005/2407 , A61M2005/3123
摘要: A-syringe for storing a freeze-dried agent therein under reduced pressure as well as a method for manufacturing the syringe. A specified amount of a chemical is injected into a cartridge with the one end of the cartridge down. The gasket is plugged halfway on the other end side of the cartridge, so that the cartridge is made communicating between inside and outside by the recessed groove, in which state the chemical is freeze-dried. The sealing cap is overlaid on an upper end face of the gasket and the sealing cap is pushed in the reduced-pressure atmosphere so that the other end side of the cartridge is sealed by the gasket and the sealing cap. The sealing cap is engaged with an end face of the cartridge on the other end side, thereby being prevented from moving into the cartridge.
摘要翻译: 用于在减压下储存冷冻干燥剂的A型注射器以及制造注射器的方法。 将指定量的化学品注入到盒的一端向下的盒中。 垫片在盒的另一端侧插入中间,使得盒通过凹槽在内部和外部之间连通,在该状态下化学品被冷冻干燥。 密封帽覆盖在垫圈的上端面上,并且密封帽在减压气氛中推动,使得盒的另一端侧被垫圈和密封帽密封。 密封帽与另一端侧的盒的端面接合,从而被阻止移入盒中。
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公开(公告)号:US20130225492A1
公开(公告)日:2013-08-29
申请号:US13824598
申请日:2011-10-14
申请人: Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
发明人: Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
CPC分类号: A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要: Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译: 本发明提供包含药物和胶原的药物组合物,其组合物的操作性良好且具有缓释性。 缓释药物组合物包括:药物; 胶原蛋白 和选自单糖,二糖,三糖和四糖中的至少一种糖。 本发明的发明人已经发现,含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。 基于该发现,本发明人发现含有药物,胶原和糖的组合物可以控制药物的释放速度,并且这种组合物可以用作缓释药物组合物。
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公开(公告)号:US09301917B2
公开(公告)日:2016-04-05
申请号:US13824598
申请日:2011-10-14
申请人: Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
发明人: Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
IPC分类号: A61K38/00 , A61K9/00 , A61K31/7004 , A61K31/7008 , A61K45/06 , A61K38/39 , A61K9/51 , A61K47/26 , A61K47/42 , A61K38/27 , A61K38/18
CPC分类号: A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要: Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译: 本发明提供包含药物和胶原的药物组合物,其组合物的操作性良好且具有缓释性。 缓释药物组合物包括:药物; 胶原蛋白 和选自单糖,二糖,三糖和四糖中的至少一种糖。 本发明的发明人已经发现,含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。 基于该发现,本发明人发现含有药物,胶原和糖的组合物可以控制药物的释放速度,并且这种组合物可以用作缓释药物组合物。
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公开(公告)号:US5482929A
公开(公告)日:1996-01-09
申请号:US996392
申请日:1992-12-23
申请人: Kazuhiro Fukunaga , Shigeki Hijikata , Kimihiro Ishimura , Yoshiro Ohtani , Kunio Kimura , Masahiro Fujii , Yoshiyuki Hata
发明人: Kazuhiro Fukunaga , Shigeki Hijikata , Kimihiro Ishimura , Yoshiro Ohtani , Kunio Kimura , Masahiro Fujii , Yoshiyuki Hata
CPC分类号: B82Y5/00 , A61K47/40 , A61K47/48969 , A61K9/0014 , C07K14/501 , C07K14/503 , A61K38/00
摘要: A composition of a stabilized fibroblast growth factor (FGF), which contains an aluminum salt of cyclodextrin sulfate to stabilize FGF. FGF can be stabilized by forming a composition of FGF and an aluminum salt of cyclodextrin sulfate, and can be stably prepared into formulations.
摘要翻译: 稳定的成纤维细胞生长因子(FGF)的组合物,其含有硫酸环糊精的铝盐以稳定FGF。 可以通过形成FGF组合物和硫酸环糊精的铝盐来稳定FGF,并且可以稳定地制备成制剂。
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