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    Pharmaceutical composition for oral use with improved absorption
    3.
    发明授权
    Pharmaceutical composition for oral use with improved absorption 有权
    用于口服使用的药物组合物具有改善的吸收

    公开(公告)号：US07923025B2

    公开(公告)日：2011-04-12

    申请号：US10345051

    申请日：2003-01-15

    申请人： Shunsuke Watanabe ,  Kiyo Nakanishi ,  Shigeo Takemura ,  Yuuki Tsutsui

    发明人： Shunsuke Watanabe ,  Kiyo Nakanishi ,  Shigeo Takemura ,  Yuuki Tsutsui

    IPC分类号： A61K9/46 ,  A61K9/20

    CPC分类号： A61K9/0095 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2853 ,  A61K9/4866 ,  A61K31/785 ,  A61K38/11 ,  A61K38/23 ,  A61K38/28 ,  A61K47/32 ,  A61K2300/00

    摘要： The present invention relates to an agent for inhibiting decomposition of a biologically active peptide by a digestive enzyme, which is aminoalkyl methacrylate copolymer E as an effective ingredient, and an agent for reducing viscosity of the gastrointestinal mucosa and mucous layers distributed over this mucosa. The present invention relates to a method for inhibiting decomposition of a biologically active peptide by a digestive enzyme, or a method for reducing viscosity of the gastrointestinal mucosa and/or mucous layers distributed over the mucosa, by administration of aminoalkyl methacrylate copolymer E. Furthermore, the present invention relates to a pharmaceutical composition for oral use with improved absorption, which comprises a biologically active peptide and aminoalkyl methacrylate copolymer E. Excellent oral absorption of a biologically active peptide that were considered difficult to absorb by oral administration in the past, can be realized based on the ability to inhibit decomposition of a biologically active peptide, the ability to reduce viscosity of the gastrointestinal mucosa and/or mucous layers distributed over this mucosa, and the ability to improve permeability of a biologically active peptide in the gastrointestinal mucosa and/or mucous layers of the pharmaceutical composition of the present invention.

    摘要翻译： 本发明涉及通过消化酶抑制生物活性肽分解的试剂，其为甲基丙烯酸氨基烷基酯共聚物E作为有效成分，以及用于降低分布在该粘膜上的胃肠粘膜和粘液层的粘度的试剂。 本发明涉及通过使用氨基烷基甲基丙烯酸酯共聚物E来抑制由消化酶分解生物活性肽的方法或降低分布在粘膜上的胃肠粘膜和/或粘膜层粘度的方法。此外， 本发明涉及具有改善吸收性的口服用药物组合物，其包含生物活性肽和甲基丙烯酸氨基烷基酯共聚物E.过去通过口服给药难以吸收的生物活性肽的良好口服吸收可以是 基于抑制生物活性肽分解的能力实现，降低分布在该粘膜上的胃肠粘膜和/或粘液层的粘度的能力，以及提高生物活性肽在胃肠粘膜和/ 或药物组合物的粘液层 本发明的范围。

    Pharmaceutical composition for oral use with improved absorption
    5.
    发明授权
    Pharmaceutical composition for oral use with improved absorption 有权
    用于口服使用的药物组合物具有改善的吸收

    公开(公告)号：US07871644B2

    公开(公告)日：2011-01-18

    申请号：US10949114

    申请日：2004-09-10

    申请人： Shunsuke Watanabe ,  Shigeo Takemura ,  Yuuki Tsutsui ,  Himoru Kondo ,  Kiyo Nakanishi ,  Kazuhiro Sako ,  Toyohiro Sawada

    发明人： Shunsuke Watanabe ,  Shigeo Takemura ,  Yuuki Tsutsui ,  Himoru Kondo ,  Kiyo Nakanishi ,  Kazuhiro Sako ,  Toyohiro Sawada

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K9/48

    CPC分类号： A61K9/2027 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2893 ,  A61K31/65 ,  A61K31/663 ,  A61K47/12 ,  A61K47/32

    摘要： The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption/by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

    摘要翻译： 本发明提供了具有改善吸收性的口服用药物组合物，其包括药物，甲基丙烯酸氨基烷基酯共聚物E和酸性物质，并且通过使所述3种组分一起并将至少该聚合物与该酸性物质均匀混合而获得， 通过使用该药物组合物改善口服吸收。 此外，本发明提供了改善口服吸收的药剂，其增加存在于该膜的表面上的消化道粘膜和/或粘膜层的药物通透性，其活性成分是甲基丙烯酸氨基烷基酯共聚物E.另外，本发明 提出了通过增加分泌在该粘膜上的消化道粘膜和/或粘膜层的药物通透性来改善吸收的口服剂，其有效成分是甲基丙烯酸氨基烷基酯共聚物E.

    Electric control apparatus for equipment
    6.
    发明授权
    Electric control apparatus for equipment 失效
    设备电气控制装置

    公开(公告)号：US4736145A

    公开(公告)日：1988-04-05

    申请号：US992023

    申请日：1986-10-21

    申请人： Hidetoshi Sakurai ,  Tomoaki Abe ,  Shigeo Takemura

    发明人： Hidetoshi Sakurai ,  Tomoaki Abe ,  Shigeo Takemura

    IPC分类号： H02H11/00 ,  B60R16/02 ,  B60R16/03 ,  B60R16/04 ,  F02D41/00 ,  F02D41/20 ,  F02D41/22 ,  F02D41/30 ,  G01R19/165 ,  G05B9/02 ,  H02H3/24

    CPC分类号： G05B9/02 ,  F02D41/22 ,  F02D41/3005 ,  F02D2200/503

    摘要： Electric control apparatus (20) for equipment (1) comprising a driving circuit (5) for generating a signal (S.sub.1) to drive the equipment as installed in a vehicle, the driving circuit including circuitry having a first specified working voltage range, and a breaking circuit (6) operatively interposed between the driving circuit and the equipment, the breaking circuit including a first switching circuit (100) for operatively interrupting the supply of the drive signal to the equipment under a condition that the supply voltage (Vdd) is lowered below a first predetermined level (V.sub.1) set lower than a normal level with respect to the first working voltage range, the first switching circuit including circuitry having a second specified working voltage range not exceeding the upper limit of the first working voltage range, wherein the breaking circuit further includes a second switching circuit (10) operatively interposed between the first switching circuit and the equipment, the second switching circuit operatively interrupting the supply of the drive signal to the equipment under a condition that the supply voltage is lowered below a second predetermined level (V.sub.2) set lower than the first predetermined level and higher than the lower limit of the second working voltage range.

    摘要翻译： 一种用于设备（​​1）的电气控制装置（20），包括用于产生安装在车辆中的驱动设备的信号（S1）的驱动电路（5），所述驱动电路包括具有第一规定工作电压范围的电路，以及 断开电路（6）可操作地插入在驱动电路和设备之间，断路电路包括第一开关电路（100），用于在电源电压（Vdd）降低的条件下可操作地中断向设备提供驱动信号 低于相对于第一工作电压范围的正常电平的第一预定电平（V1），第一开关电路包括具有不超过第一工作电压范围的上限的第二规定工作电压范围的电路，其中， 断路电路还包括可操作地插入在第一开关电路和设备之间的第二开关电路（10），第二开关 在电源电压降低到低于第一预定电平并低于第二工作电压范围的下限的第二预定电平（V2）的条件下，可操作地中断向设备供电的驱动信号。