利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.026 秒)

    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane
    3.
    发明授权
    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane 失效
    制备3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物和4-酰基四氢吡喃的方法

    公开(公告)号：US07741497B2

    公开(公告)日：2010-06-22

    申请号：US10583473

    申请日：2004-12-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： C07D309/06

    CPC分类号： C07D309/06

    摘要： The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

    摘要翻译： 本发明提供一种制备式（1）表示的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：其中R 1和R 2可以相同或不同，并且表示基团 其不参与反应，并且R 1和R 2可以键合形成环，并且该环可以含有杂原子，并且R 3表示烃基，其包括使由式（Ⅳ）表示的4-酰基四氢吡喃与 2）：其中R1和R2具有与上述相同的含义，和由式（3）表示的碳酸二酯：其中R 3具有与上述相同的含义，并且两个R 3可以彼此键合形成 在碱的存在下，以及制备4-酰基四氢吡喃的方法。

    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane
    4.
    发明申请
    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane 失效
    制备3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物和4-酰基四氢吡喃的方法

    公开(公告)号：US20070043107A1

    公开(公告)日：2007-02-22

    申请号：US10583473

    申请日：2004-12-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： A61K31/35 ,  C07D309/06

    CPC分类号： C07D309/06

    摘要： The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

    摘要翻译： 本发明提供一种制备由式（1）表示的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：其中R 1和R 2， SUP>可以相同也可以不同，表示不参与反应的基团，R 1和R 2可以相互键合形成 环可以含有杂原子，R 3表示烃基，其包括使由式（2）表示的4-酰基四氢吡喃：其中R 1， / O 2和R 2具有与上述相同的含义，和由式（3）表示的碳酸二酯：其中R 3具有与所定义的相同的含义 并且两个R 3可以在碱的存在下彼此键合形成环，以及制备4-酰基四氢吡喃的方法。

    Method for producing nitrile compound, carboxylic acid compound or carboxylate compound
    5.
    发明申请
    Method for producing nitrile compound, carboxylic acid compound or carboxylate compound 有权
    腈化合物，羧酸化合物或羧酸酯化合物的制造方法

    公开(公告)号：US20060287541A1

    公开(公告)日：2006-12-21

    申请号：US10572373

    申请日：2004-09-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： C07D309/14

    CPC分类号： C07C253/30 ,  C07C51/00

    摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.

    摘要翻译： 本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2， 具有与上述相同的含义，在金属催化剂的存在下脱羧。

    Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound
    6.
    发明申请
    Process for Preparing Tetrahydropyran-4-Carboxylic Acid Compound 审中-公开
    制备四氢吡喃-4-羧酸化合物的方法

    公开(公告)号：US20080306287A1

    公开(公告)日：2008-12-11

    申请号：US11668000

    申请日：2005-11-18

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Taku Nakamura ,  Keiji Iwamoto

    IPC分类号： C07D309/08

    CPC分类号： C07D309/08

    摘要： The present invention is to provide a process for preparing tetrahydropyran-4-carboxylic acid represented by the formula (1): which comprises hydrolyzing a 4-cyanotetrahydropyran-4-carboxylic acid compound represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, in the presence of an acid; a process for preparing a tetrahydropyran-4-carboxylic acid ester which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with an alcohol in the presence of an acid; and a process for preparing tetrahydropyran-4-carboxylic acid amide which comprises reacting the tetrahydropyran-4-carboxylic acid represented by the above-mentioned formula (1) with a halogenating agent to prepare tetrahydropyran-4-carboxylic acid halide, and then, reacting an amine compound to the resulting compound.

    摘要翻译： 本发明提供一种制备由式（1）表示的四氢吡喃-4-羧酸的方法：其包括水解由式（2）表示的4-氰基四氢吡喃-4-羧酸化合物：其中R表示氢 原子或烃基，在酸的存在下; 制备四氢吡喃-4-羧酸酯的方法，其包括在酸存在下使由上述式（1）表示的四氢吡喃-4-羧酸与醇反应; 以及制备四氢吡喃-4-羧酸酰胺的方法，其包括使由上述式（1）表示的四氢吡喃-4-羧酸与卤化剂反应以制备四氢吡喃-4-羧酸卤化物，然后使 向所得化合物中加入胺化合物。

    Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound
    7.
    发明授权
    Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound 有权
    腈化合物，羧酸化合物或羧酸酯化合物的制备方法

    公开(公告)号：US07300953B2

    公开(公告)日：2007-11-27

    申请号：US10572373

    申请日：2004-09-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Keiji Iwamoto ,  Takashi Harada

    IPC分类号： A61K31/075 ,  C07D309/08

    CPC分类号： C07C253/30 ,  C07C51/00

    摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.

    摘要翻译： 本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2， 具有与上述相同的含义，在金属催化剂的存在下脱羧。

    Processes for preparing tetrahydropyran-4-one and pyran-4-one
    9.
    发明授权
    Processes for preparing tetrahydropyran-4-one and pyran-4-one 有权
    制备四氢吡喃-4-酮和吡喃-4-酮的方法

    公开(公告)号：US07745649B2

    公开(公告)日：2010-06-29

    申请号：US10583562

    申请日：2004-12-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

    IPC分类号： C07D309/30

    CPC分类号： C07D309/38 ,  C07C45/00 ,  C07C49/185 ,  C07D309/30

    摘要： The present invention relates to a process for preparing tetrahydropyran-4-one represented by the formula (1): which comprises reacting at least one kind of dihydropyran-4-one and pyran-4-one represented by the formula (2): wherein represents a single bond or a double bond, and hydrogen (a) in the presence of a metal catalyst, in a mixed solvent of an aprotic solvent and an alcohol solvent, or (b) in the presence of an anhydrous metal catalyst in which a hydrated metal catalyst is subjected to dehydration treatment, in a hydrophobic organic solvent.

    摘要翻译： 本发明涉及一种由式（1）表示的四氢吡喃-4-酮的制备方法：其包括使由式（2）表示的至少一种二氢吡喃-4-酮和吡喃-4-酮：其中 表示单键或双键，氢（a）在金属催化剂的存在下，在非质子溶剂和醇溶剂的混合溶剂中，或（b）在无水金属催化剂存在下，其中 水合金属催化剂在疏水性有机溶剂中进行脱水处理。

    Processes for preparing tetrahydropyran-4-one and pyran-4-one
    10.
    发明申请
    Processes for preparing tetrahydropyran-4-one and pyran-4-one 有权
    制备四氢吡喃-4-酮和吡喃-4-酮的方法

    公开(公告)号：US20070078272A1

    公开(公告)日：2007-04-05

    申请号：US10583562

    申请日：2004-12-17

    申请人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

    发明人： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Shinobu Suzuki

    IPC分类号： C07D315/00

    CPC分类号： C07D309/38 ,  C07C45/00 ,  C07C49/185 ,  C07D309/30

    摘要： The present invention relates to a process for preparing tetrahydropyran-4-one represented by the formula (1): which comprises reacting at least one kind of dihydropyran-4-one and pyran-4-one represented by the formula (2): wherein represents a single bond or a double bond, and hydrogen (a) in the presence of a metal catalyst, in a mixed solvent of an aprotic solvent and an alcohol solvent, or (b) in the presence of an anhydrous metal catalyst in which a hydrated metal catalyst is subjected to dehydration treatment, in a hydrophobic organic solvent.

    摘要翻译： 本发明涉及一种由式（1）表示的四氢吡喃-4-酮的制备方法：其包括使由式（2）表示的至少一种二氢吡喃-4-酮和吡喃-4-酮：其中 “img id =”custom-character-00001“he =”3.13mm“wi =”6.35mm“file =”US20070078272A1-20070405-P00900.TIF“alt =”custom character“img-content =”character“img-format =“tif”/>表示单键或双键，氢（a）在金属催化剂存在下，在非质子溶剂和醇溶剂的混合溶剂中，或（b）在 在疏水性有机溶剂中，将水合金属催化剂进行脱水处理的无水金属催化剂。