公开(公告)号：US4560748A

公开(公告)日：1985-12-24

申请号：US500908

申请日：1983-06-03

申请人： Shigezo Udaka ,  Shigeyoshi Miyashiro ,  Kazuo Hirayama ,  Toshihiko Ando ,  Asao Murai ,  Tsuyoshi Shiio ,  Takao Kida ,  Hiroshiro Shibai

发明人： Shigezo Udaka ,  Shigeyoshi Miyashiro ,  Kazuo Hirayama ,  Toshihiko Ando ,  Asao Murai ,  Tsuyoshi Shiio ,  Takao Kida ,  Hiroshiro Shibai

IPC分类号： C12P21/02 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07H17/02 ,  C12P19/28 ,  C07H17/00

CPC分类号： C12R1/465 ,  C07H17/02 ,  C12P19/28

摘要： A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.

摘要翻译： 公开了具有下式的其中R表示 + TR 的下式的链霉菌素基化合物以及用于生产该化合物的方法和用于其生产的微生物。

公开(公告)号：US4294754A

公开(公告)日：1981-10-13

申请号：US27029

申请日：1979-04-04

申请人： Yoshiyuki Takahara ,  Yoshiteru Hirose ,  Yoko Takeuchi ,  Asao Murai ,  Masatsune Kainosho ,  Sawao Murao

发明人： Yoshiyuki Takahara ,  Yoshiteru Hirose ,  Yoko Takeuchi ,  Asao Murai ,  Masatsune Kainosho ,  Sawao Murao

IPC分类号： A61K35/74 ,  A61K38/00 ,  A61P31/04 ,  C07K7/06 ,  C07K11/00 ,  C07K11/02 ,  C07K14/195 ,  C07K14/41 ,  C12P21/04 ,  C07C103/52

CPC分类号： C07K7/06 ,  C12R1/09 ,  Y10S930/19 ,  Y10S930/27

摘要： A purified ring peptide antibiotic of the following empirical formula:N.alpha.-(3-hydroxy-4-methyl-1-oxohexyl)-L-.alpha.,.gamma.-diaminobutyryl-L-isoleucyl-L-.alpha.,.gamma.-diaminobutyryl-D-phenylalanyl-L-leucyl-L-.alpha.,.gamma.-diaminobutyryl-D-valyl-L-leucyl-L-serine (9-1)-lactoneand which has the following structural formula: ##STR1## and wherein Dab represents 2,4-diamino butyric acid.

摘要翻译： 具有以下经验式的纯化的环肽抗生素：Nα-（3-羟基-4-甲基-1-氧代己基）-L-α，γ-二氨基丁酰基-L-异亮氨酰-L-α，γ-二氨基丁酰基-D- 苯丙氨酰-L-亮氨酰-L-α，γ-二氨基丁酰-D-缬氨酰-L-亮氨酰-L-丝氨酸（9-1） - 内酯，其具有以下结构式：其中Dab表示2,4 - 二氨基丁酸。

公开(公告)号：US4918005A

公开(公告)日：1990-04-17

申请号：US74745

申请日：1987-07-17

申请人： Asao Murai ,  Masao Yamamoto

发明人： Asao Murai ,  Masao Yamamoto

IPC分类号： C12Q1/02 ,  G01N33/82

CPC分类号： G01N33/82 ,  C12Q1/02

摘要： The present invention is directed to a method of quantitative assay for a vitamin B.sub.12 -containing substance which comprises culturing marine methanol-utilizing bacteria having B.sub.12 auxotrophy in a medium for quantitative assay of the bacteria containing pyrroloquinoline-quinone and a polyoxyethylene sorbitan fatty acid ester and, quantitatively determining vitamin B.sub.12 in the vitamin B.sub.12 -containing substance as a function of the degree of growth thereof and, to a reagent for the B.sub.12 -containing substance comprising a kit for combination of an ampule or vial having sealed therein a dry viable bacteria composition of a marine methanol-utilizing bacteria for inoculation and an ampule or vial having sealed therein a medium for the bacteria containing pyrroloquinoline-quinone and a polyoxyethylene sorbitan fatty acid ester, or in addition thereto, further an ampule or vial having sealed therein a standard dilution of vitamin B.sub.12 having a serial concentration.