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1.发明申请公开(公告)号：US20130065293A1
公开(公告)日：2013-03-14
申请号：US13666220
申请日：2012-11-01
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
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2.发明授权
公开(公告)号：US5290695A
公开(公告)日：1994-03-01
申请号：US843812
申请日：1992-02-28
CPC分类号： C12R1/09 , C12N9/88 , Y10S435/835
摘要： Disclosed are novel enzymes, heparitinase T-I, heparitinase T-II, heparitinase T-III and heparitinase T-IV, which degrade heparan sulfate and/or heparin, a process for producing thereof by cultivating a novel Bacillus circulans HpT 298 having an ability of producing these enzymes and a novel Bacillus circulans HpT 298.
摘要翻译： 公开了通过培养具有生产能力的新型环状芽孢杆菌HpT 298的新型酶，肝素酶，TI，肝素酶T-II，肝素三磷酸酶T-III和肝素三磷酸酶T-IV，其降解硫酸肝素和/或肝素 这些酶和新型环状芽孢杆菌HpT 298。
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3.发明授权Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权分支的α-葡聚糖，形成葡聚糖的α-葡萄糖基转移酶，其制备和用途公开(公告)号：US08673608B2
公开(公告)日：2014-03-18
申请号：US13666220
申请日：2012-11-01
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡萄糖基转移酶，其制备方法及其用途。
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4.发明授权Enzymatic hydrolysis method for the conversion of C-7 sugar to C-7 hydroxyl taxanes 失效C-7糖转化为C-7羟基紫杉烷的酶水解法
公开(公告)号：US5700669A
公开(公告)日：1997-12-23
申请号：US421017
申请日：1995-04-12
IPC分类号： C12N1/20 , C12N9/24 , C12P17/02 , C12P19/60 , C12Q1/02 , C12Q1/04 , C12Q1/34 , C12R1/01 , C12R1/07 , C12R1/09 , C12R1/265
CPC分类号： C12R1/07 , C12N9/248 , C12P17/02 , C12P19/60 , C12Q1/02 , C12Q1/04 , C12Q1/34 , C12R1/01 , C12R1/09 , C12R1/265 , G01N2333/924 , G01N2407/02
摘要： An enzymatic hydrolysis method, wherein one or more C-7 sugar, preferably C-7 xylosyl-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said sugar groups to hydroxyl groups.
摘要翻译： 一种酶水解方法，其中一种或多种C-7糖，优选含C-7木糖基的紫杉烷与能够将所述糖基水解成羟基的酶或微生物接触。
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公开(公告)号：US4360593A
公开(公告)日：1982-11-23
申请号：US346451
申请日：1982-02-08
CPC分类号： C12R1/09 , C07K7/62 , A61K38/00 , Y10S435/835
摘要： A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
摘要翻译： 本文命名为Bu-2470的新型肽抗生素复合物是通过环状芽孢杆菌菌株G493-B6（ATCC 31,805）的发酵产生的。 复合物Bu-2470可以分成四种被称为Bu-2470A，B1，B2a和B2b的生物活性肽抗生素。 复杂和个体的生物活性因子具有显着的抗菌活性。
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6.发明申请BRANCHED ALPHA-GLUCAN, ALPHA-GLUCOSYLTRANSFERASE WHICH FORMS THE GLUCAN, THEIR PREPARATION AND USES 有权分支的ALPHA-GLUCAN，ALPHA-GLUCOSYLTRANSFERASE，其形成葡萄糖，其制备和用途公开(公告)号：US20150267234A1
公开(公告)日：2015-09-24
申请号：US14734607
申请日：2015-06-09
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。
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公开(公告)号：US4341768A
公开(公告)日：1982-07-27
申请号：US250987
申请日：1981-04-03
IPC分类号： C12P21/04 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/60 , C07K7/62 , C07K14/195 , C07K14/41 , C12R1/09 , A61K37/00 , A61K35/00 , C07C103/52
CPC分类号： C12R1/09 , C07K7/62 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
摘要翻译： 本文命名为Bu-2470的新型肽抗生素复合物是通过环状芽孢杆菌菌株G493-B6（ATCC 31,805）的发酵产生的。 复合物Bu-2470可以分成四种被称为Bu-2470A，B1，B2a和B2b的生物活性肽抗生素。 复杂和个体的生物活性因子具有显着的抗菌活性。
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8.发明授权
公开(公告)号：US4294754A
公开(公告)日：1981-10-13
申请号：US27029
申请日：1979-04-04
申请人： Yoshiyuki Takahara , Yoshiteru Hirose , Yoko Takeuchi , Asao Murai , Masatsune Kainosho , Sawao Murao
发明人： Yoshiyuki Takahara , Yoshiteru Hirose , Yoko Takeuchi , Asao Murai , Masatsune Kainosho , Sawao Murao
IPC分类号： A61K35/74 , A61K38/00 , A61P31/04 , C07K7/06 , C07K11/00 , C07K11/02 , C07K14/195 , C07K14/41 , C12P21/04 , C07C103/52
CPC分类号： C07K7/06 , C12R1/09 , Y10S930/19 , Y10S930/27
摘要： A purified ring peptide antibiotic of the following empirical formula:N.alpha.-(3-hydroxy-4-methyl-1-oxohexyl)-L-.alpha.,.gamma.-diaminobutyryl-L-isoleucyl-L-.alpha.,.gamma.-diaminobutyryl-D-phenylalanyl-L-leucyl-L-.alpha.,.gamma.-diaminobutyryl-D-valyl-L-leucyl-L-serine (9-1)-lactoneand which has the following structural formula: ##STR1## and wherein Dab represents 2,4-diamino butyric acid.
摘要翻译： 具有以下经验式的纯化的环肽抗生素：Nα-（3-羟基-4-甲基-1-氧代己基）-L-α，γ-二氨基丁酰基-L-异亮氨酰-L-α，γ-二氨基丁酰基-D- 苯丙氨酰-L-亮氨酰-L-α，γ-二氨基丁酰-D-缬氨酰-L-亮氨酰-L-丝氨酸（9-1） - 内酯，其具有以下结构式：其中Dab表示2,4 - 二氨基丁酸。
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9.发明授权Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权形成葡聚糖的分支α-葡聚糖，α-葡萄糖基转移酶，其制备和应用公开(公告)号：US09528134B2
公开(公告)日：2016-12-27
申请号：US14734607
申请日：2015-06-09
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/04 , C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12R1/06 , C12R1/09
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。
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10.发明授权Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses 有权分支的α-葡聚糖，形成葡聚糖的α-葡萄糖基转移酶，其制备和用途公开(公告)号：US09090923B2
公开(公告)日：2015-07-28
申请号：US14160749
申请日：2014-01-22
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12P19/04 , C12R1/06 , C12R1/09
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitolis 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）在部分甲基化的葡萄糖醇中的2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的总含量为60％以上 醋酸盐 （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。
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