公开(公告)号：US20120189571A1

公开(公告)日：2012-07-26

申请号：US13147751

申请日：2010-02-04

申请人： Shiladitya Sengupta ,  Abhimanyu Paraskar ,  Shivani Soni ,  Sudipta Basu ,  Poulomi Sengupta

发明人： Shiladitya Sengupta ,  Abhimanyu Paraskar ,  Shivani Soni ,  Sudipta Basu ,  Poulomi Sengupta

IPC分类号： A61K31/785 ,  A61K31/795 ,  A61P35/00 ,  A61P35/04 ,  C08F8/32 ,  C08F122/06 ,  C08F122/02 ,  C07J41/00 ,  C07F15/00 ,  B82Y5/00 ,  B82B1/00

CPC分类号： A61K47/489 ,  A61K31/282 ,  A61K31/382 ,  A61K33/24 ,  A61K47/16 ,  A61K47/24 ,  A61K47/48046 ,  A61K47/48053 ,  A61K47/48176 ,  A61K47/48215 ,  A61K47/543 ,  A61K47/544 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6933 ,  C07J41/0055 ,  C08F8/32 ,  C08F22/06 ,  C08F222/06

摘要： The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

摘要翻译： 本发明涉及生物相容的共轭聚合物纳米颗粒，其包括共聚物主链，与所述主链共价连接的多个侧链，以及与所述主链离解连接的多个铂化合物。 本发明还涉及其中铂化合物与二羰基化合物离解连接的二羰基 - 脂质化合物。 本发明还涉及治疗癌症或转移的方法。 所述方法包括选择需要治疗癌症或转移的受试者，并向受试者施用有效量的本发明的任何纳米颗粒，化合物或组合物。

公开(公告)号：US09393227B2

公开(公告)日：2016-07-19

申请号：US13147751

申请日：2010-02-04

申请人： Shiladitya Sengupta ,  Abhimanyu Paraskar ,  Shivani Soni ,  Sudipta Basu ,  Poulomi Sengupta

发明人： Shiladitya Sengupta ,  Abhimanyu Paraskar ,  Shivani Soni ,  Sudipta Basu ,  Poulomi Sengupta

IPC分类号： A61K31/785 ,  A61K31/795 ,  A61P35/00 ,  A61P35/04 ,  C08F8/32 ,  C08F122/02 ,  C07J41/00 ,  C07F15/00 ,  B82Y5/00 ,  B82B1/00 ,  A61K31/382 ,  A61K47/24 ,  A61K47/48 ,  A61K47/16 ,  C08F22/06 ,  C08F222/06

CPC分类号： A61K47/489 ,  A61K31/282 ,  A61K31/382 ,  A61K33/24 ,  A61K47/16 ,  A61K47/24 ,  A61K47/48046 ,  A61K47/48053 ,  A61K47/48176 ,  A61K47/48215 ,  A61K47/543 ,  A61K47/544 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6933 ,  C07J41/0055 ,  C08F8/32 ,  C08F22/06 ,  C08F222/06

摘要： The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

摘要翻译： 本发明涉及生物相容的共轭聚合物纳米颗粒，其包括共聚物主链，与所述主链共价连接的多个侧链，以及与所述主链离解连接的多个铂化合物。 本发明还涉及其中铂化合物与二羰基化合物离解连接的二羰基 - 脂质化合物。 本发明还涉及治疗癌症或转移的方法。 所述方法包括选择需要治疗癌症或转移的受试者，并向受试者施用有效量的本发明的任何纳米颗粒，化合物或组合物。

公开(公告)号：US20120052041A1

公开(公告)日：2012-03-01

申请号：US13147755

申请日：2010-02-04

申请人： Sudipta Basu ,  Rania Harfouche ,  Shivani Soni ,  Shiladitya Sengupta

发明人： Sudipta Basu ,  Rania Harfouche ,  Shivani Soni ,  Shiladitya Sengupta

IPC分类号： A61K47/48 ,  A61P35/00 ,  A61K47/34 ,  B82Y5/00

CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/5192 ,  A61K47/36 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6937 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  B82Y5/00

摘要： The invention is directed to modified polymers with increased drug-loading including compounds of formula (I): wherein Z is a poly(lactic-co-glycolic acid) (PLGA) polymer having molecular weight from 1-15 kDa and where the ratio of lactide to glycolide in the PLGA polymer is from 1:10 to 10:1; formula (II) R1 are independently H, R2, OH, O-alkyl, —O—R2, NH—R2, -linker-R2, or -and R2 are independently one or more therapeutic agents. The invention is also directed to nanoparticle drug delivery systems including a PLGA-b-PEG block copolymer; and a stabilizer and to drug delivery systems including PLGA-b-PEG block copolymer polyvinyl alcohol (PVA) nanoparticle; and the modified polymer substantially as described herein.

摘要翻译： 本发明涉及具有增加的药物负载量的改性聚合物，包括式（I）化合物：其中Z是分子量为1-15kDa的聚（乳酸 - 共 - 乙醇酸）（PLGA）聚合物，其中 丙交酯与乙交酯在PLGA聚合物中的摩尔比为1:10至10:1; 式（II）R1独立地是H，R2，OH，O-烷基，-O-R2，NH-R2， - 连接子-R2或 - 和R2独立地是一种或多种治疗剂。 本发明还涉及包括PLGA-b-PEG嵌段共聚物的纳米颗粒药物递送系统; 和稳定剂和药物递送系统，包括PLGA-b-PEG嵌段共聚物聚乙烯醇（PVA）纳米颗粒; 和基本如本文所述的改性聚合物。