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    POLYMERIC NANOPARTICLES WITH ENHANCED DRUG-LOADING AND METHODS OF USE THEREOF
    3.
    发明申请
    POLYMERIC NANOPARTICLES WITH ENHANCED DRUG-LOADING AND METHODS OF USE THEREOF 审中-公开
    具有增强药物加载的聚合纳米粒子及其使用方法

    公开(公告)号：US20120052041A1

    公开(公告)日：2012-03-01

    申请号：US13147755

    申请日：2010-02-04

    申请人： Sudipta Basu ,  Rania Harfouche ,  Shivani Soni ,  Shiladitya Sengupta

    发明人： Sudipta Basu ,  Rania Harfouche ,  Shivani Soni ,  Shiladitya Sengupta

    IPC分类号： A61K47/48 ,  A61P35/00 ,  A61K47/34 ,  B82Y5/00

    CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/5192 ,  A61K47/36 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6937 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  B82Y5/00

    摘要： The invention is directed to modified polymers with increased drug-loading including compounds of formula (I): wherein Z is a poly(lactic-co-glycolic acid) (PLGA) polymer having molecular weight from 1-15 kDa and where the ratio of lactide to glycolide in the PLGA polymer is from 1:10 to 10:1; formula (II) R1 are independently H, R2, OH, O-alkyl, —O—R2, NH—R2, -linker-R2, or -and R2 are independently one or more therapeutic agents. The invention is also directed to nanoparticle drug delivery systems including a PLGA-b-PEG block copolymer; and a stabilizer and to drug delivery systems including PLGA-b-PEG block copolymer polyvinyl alcohol (PVA) nanoparticle; and the modified polymer substantially as described herein.

    摘要翻译： 本发明涉及具有增加的药物负载量的改性聚合物，包括式（I）化合物：其中Z是分子量为1-15kDa的聚（乳酸 - 共 - 乙醇酸）（PLGA）聚合物，其中 丙交酯与乙交酯在PLGA聚合物中的摩尔比为1:10至10:1; 式（II）R1独立地是H，R2，OH，O-烷基，-O-R2，NH-R2， - 连接子-R2或 - 和R2独立地是一种或多种治疗剂。 本发明还涉及包括PLGA-b-PEG嵌段共聚物的纳米颗粒药物递送系统; 和稳定剂和药物递送系统，包括PLGA-b-PEG嵌段共聚物聚乙烯醇（PVA）纳米颗粒; 和基本如本文所述的改性聚合物。

    Nanocells for diagnosis and treatment of diseases and disorders
    5.
    发明申请
    Nanocells for diagnosis and treatment of diseases and disorders 审中-公开
    用于诊断和治疗疾病和障碍的纳米细胞

    公开(公告)号：US20070065359A1

    公开(公告)日：2007-03-22

    申请号：US11375475

    申请日：2006-03-14

    申请人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos Bosques

    发明人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos Bosques

    IPC分类号： A61K51/00

    CPC分类号： A61K51/1241 ,  A61K9/1271 ,  A61K9/14 ,  A61K45/06 ,  A61K47/6923 ,  A61K47/6929 ,  A61K51/1244 ,  B82Y5/00 ,  B82Y10/00

    摘要： The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.

    摘要翻译： 本发明涉及新型纳米电池组合物及其在成像，诊断和治疗方法中的应用。 在一个实施方案中，针对成像方法定制的纳细胞包括由脂质基质包围的纳米孔，并且被修饰为含有放射性核素或具有发射光谱的纳米孔。 纳米细胞的尺寸受限于大于约60nm，使得它们在血管发生（例如肿瘤）的位置选择性地外渗，并且不通过正常的脉管系统或进入非肿瘤的组织。 以这种方式，可以检测和治疗血管生成位点。 在另一个实施方案中，针对各种治疗方法，包括治疗脑癌，哮喘，格雷夫氏病，囊性纤维化和肺纤维化，纳米细胞被定制。

    Nanocells for Diagnosis and Treatment of Diseases and Disorders
    7.
    发明申请
    Nanocells for Diagnosis and Treatment of Diseases and Disorders 审中-公开
    用于诊断和治疗疾病和疾病的纳米细胞

    公开(公告)号：US20090110633A1

    公开(公告)日：2009-04-30

    申请号：US11886283

    申请日：2006-03-14

    申请人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos J. Bosques ,  David A. Eavarone ,  Pochi Shum

    发明人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos J. Bosques ,  David A. Eavarone ,  Pochi Shum

    IPC分类号： A61K51/00

    CPC分类号： A61K51/1241 ,  A61K9/1271 ,  A61K9/14 ,  A61K45/06 ,  A61K47/6923 ,  A61K47/6929 ,  A61K51/1244 ,  B82Y5/00 ,  B82Y10/00

    摘要： The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.

    摘要翻译： 本发明涉及新型纳米电池组合物及其在成像，诊断和治疗方法中的应用。 在一个实施方案中，针对成像方法定制的纳细胞包括由脂质基质包围的纳米孔，并且被修饰为含有放射性核素或具有发射光谱的纳米孔。 纳米细胞的尺寸受限于大于约60nm，使得它们在血管发生（例如肿瘤）的位置选择性地外渗，并且不通过正常的脉管系统或进入非肿瘤的组织。 以这种方式，可以检测和治疗血管生成位点。 在另一个实施方案中，针对各种治疗方法，包括治疗脑癌，哮喘，格雷夫氏病，囊性纤维化和肺纤维化，纳米细胞被定制。

    Methods and compositions related to modulating the extracellular stem cell environment
    8.
    发明申请
    Methods and compositions related to modulating the extracellular stem cell environment 审中-公开
    与调节细胞外干细胞环境相关的方法和组合

    公开(公告)号：US20070020243A1

    公开(公告)日：2007-01-25

    申请号：US11332766

    申请日：2006-01-12

    申请人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Nishla Keiser ,  David Eavarone ,  Tanyel Kiziltepe Bilgicer ,  Aarthi Chandrasekaran ,  David Berry ,  Kristine Holley

    发明人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Nishla Keiser ,  David Eavarone ,  Tanyel Kiziltepe Bilgicer ,  Aarthi Chandrasekaran ,  David Berry ,  Kristine Holley

    IPC分类号： A61K35/12 ,  C12N5/08 ,  C12N5/06

    CPC分类号： A61K31/726 ,  A61K31/727 ,  A61K38/47 ,  C12N5/0606 ,  C12N5/0691 ,  C12N2501/70 ,  C12N2506/02

    摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.

    摘要翻译： 本发明部分涉及调节干细胞环境的方法和组合物。 更具体地，本发明部分涉及用于调节干细胞分化的方法和组合物。 在本发明的某些方面，这种调节是通过调节干细胞微环境中的糖胺聚糖（即在细胞表面上和/或细胞外基质中）上的调节剂来完成的。 因此，提供了在干细胞的微环境中调节糖胺聚糖部分，例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分的方法和组合物。 还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。 因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如，内皮细胞群体或贫血的内皮细胞群体）。 此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。 此外，本发明还部分涉及使用提供的方法和组合物的治疗方法。