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公开(公告)号：US20090258022A1
公开(公告)日：2009-10-15
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , G01N33/566 , A61P37/02
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US07829083B2
公开(公告)日：2010-11-09
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C12N5/10 , C12N5/12 , G01N33/53
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US20050037347A1
公开(公告)日：2005-02-17
申请号：US10451000
申请日：2001-12-21
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/72 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）由与SEQ ID NO：1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2，（b）由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽，其中部分氨基酸被缺失，取代或添加并且具有基本上相同的生物活性 作为多肽（a）的功能。 本发明还涉及与多肽或蛋白质结合的抗体，包含抗体的抗癌剂，筛选与蛋白质结合的物质或其肽片段的方法，以及具有至少15个碱基的多核苷酸 并且在严格条件下与根据本发明的DNA杂交，以及使用所述多核苷酸检测癌症的方法。 根据本发明的DNA是癌相关基因，并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US20060275302A1
公开(公告)日：2006-12-07
申请号：US10535733
申请日：2003-11-20
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译： 本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合 蛋白质和筛选系统。 这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽 的多肽（a）。
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公开(公告)号：US07375199B2
公开(公告)日：2008-05-20
申请号：US10451000
申请日：2001-12-21
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US08008437B2
公开(公告)日：2011-08-30
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K5/00
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US07790866B2
公开(公告)日：2010-09-07
申请号：US10535733
申请日：2003-11-20
CPC分类号： C12N9/1048 , C07K14/4748
摘要： The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
摘要翻译： 本发明提供：新型DNA，包含DNA的癌相关基因，由DNA编码的重组蛋白，与蛋白结合的抗体，包含抗体的抗癌剂，结合 蛋白质和筛选系统。 这样的新型DNA的实例是包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）多肽，由与氨基酸序列相同或基本相同的氨基酸序列组成， SEQ ID NO：2; 或（b）通过缺失，取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO：2所示的氨基酸序列衍生的氨基酸序列组成的多肽 的多肽（a）。
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公开(公告)号：US20080262202A1
公开(公告)日：2008-10-23
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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9.发明申请公开(公告)号：US20070212359A1
公开(公告)日：2007-09-13
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
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