利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

58 条记录 (耗时 0.028 秒)

    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
    5.
    发明授权
    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment 有权
    癌细胞抑制的癌细胞增殖抑制材料

    公开(公告)号：US06303151B1

    公开(公告)日：2001-10-16

    申请号：US09437193

    申请日：1999-11-09

    申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    IPC分类号： A61K3512

    CPC分类号： C12N5/0693 ,  A61K35/13 ,  C12N11/04

    摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd as measured by filtration that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells. The material or the structure containing the entrapped cells that produce the material can be administered to a subject to suppress cancer cell proliferation.

    摘要翻译： 用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。 包埋限制了培养过程中消除细胞的生长，并导致细胞在培养基中产生通过过滤测量的分子量至少为约30kd的材料，其抑制癌细胞的增殖。 通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。 截留细胞的结构可能含有10,000至500,000个细胞。 可以向受试者施用含有产生该物质的包埋细胞的材料或结构，以抑制癌细胞增殖。

    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
    6.
    发明授权
    Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment 有权
    癌细胞抑制的癌细胞增殖抑制材料

    公开(公告)号：US06224912B1

    公开(公告)日：2001-05-01

    申请号：US09188476

    申请日：1998-11-09

    申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

    IPC分类号： A61K3512

    CPC分类号： A61K35/13 ,  A61K35/36 ,  C12N5/0693 ,  C12N11/04

    摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells.

    摘要翻译： 用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。 包埋限制培养过程中消除细胞的生长，并使细胞在培养基中产生抑制癌细胞增殖的至少约30kd分子量的材料。 通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。 截留细胞的结构可能含有10,000至500,000个细胞。