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公开(公告)号：US06566130B1
公开(公告)日：2003-05-20
申请号：US09769482
申请日：2001-01-26
申请人： Shiv Srivastava , Judd W. Moul , Linda L. Xu , Takehiko Segawa
发明人： Shiv Srivastava , Judd W. Moul , Linda L. Xu , Takehiko Segawa
IPC分类号： C12N1585
CPC分类号： C07K14/4748 , C07K14/47
摘要： This invention relates to androgen-regulated nucleic acids, a polynucleotide array containing these androgen-regulated nucleic acids, and methods of using the polynucleotide array in the diagnosis and prognosis of prostate cancer.
摘要翻译： 本发明涉及雄激素调节的核酸，含有这些雄激素调节的核酸的多核苷酸阵列，以及在前列腺癌的诊断和预后中使用多核苷酸阵列的方法。
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公开(公告)号：US07537896B2
公开(公告)日：2009-05-26
申请号：US11452925
申请日：2006-06-15
申请人： Shiv Srivastava , Judd W. Moul , Linda L. Xu
发明人： Shiv Srivastava , Judd W. Moul , Linda L. Xu
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748 , C07K14/47
摘要： This invention relates to the androgen-regulated gene, PMEPA1, and proteins encoded by this gene, including variants and analogs thereof. Also provided are other androgen-regulated nucleic acids, a polynucleotide array containing these androgen-regulated nucleic acids, and methods of using the polynucleotide array in the diagnosis and prognosis of prostate cancer.
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3.发明授权Prostate-specific gene, PCGEM1, and the methods of using PCGEM1 to detect, treat, and prevent prostate cancer 有权前列腺特异性基因，PCGEM1和PCGEM1检测，治疗和预防前列腺癌的方法公开(公告)号：US06828429B1
公开(公告)日：2004-12-07
申请号：US09534072
申请日：2000-03-24
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K48/00
摘要： A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing, preventing, and treating prostate cancer and other prostate related diseases. The sequence is also useful for measuring hormone responsiveness of prostate cancer cells.
摘要翻译： 公开了在肿瘤细胞中显示前列腺特异性表达和过表达的核酸序列。 其序列和片段可用于检测，诊断，预防和治疗前列腺癌和其他前列腺相关疾病。 该序列也可用于测量前列腺癌细胞的激素反应性。
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4.发明授权Prostate specific gene, PCGEM1, and methods of using PCEGM1 to detect, treat, and prevent prostate cancer 有权前列腺特异性基因，PCGEM1以及使用PCGEM1检测，治疗和预防前列腺癌的方法公开(公告)号：US07807373B2
公开(公告)日：2010-10-05
申请号：US12166723
申请日：2008-07-02
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748 , A61K48/00
摘要： A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing, preventing, and treating prostate cancer and other prostate related diseases. The sequence is also useful for measuring hormone responsiveness of prostate cancer cells.
摘要翻译： 公开了在肿瘤细胞中显示前列腺特异性表达和过表达的核酸序列。 其序列和片段可用于检测，诊断，预防和治疗前列腺癌和其他前列腺相关疾病。 该序列也可用于测量前列腺癌细胞的激素反应性。
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5.发明申请Prostate Specific Gene, PCGEM1, and Methods of Using PCGEM1 to Detect, Treat, and Prevent Prostate Cancer 有权前列腺特异性基因，PCGEM1和使用PCGEM1检测，治疗和预防前列腺癌的方法公开(公告)号：US20100184023A1
公开(公告)日：2010-07-22
申请号：US12166723
申请日：2008-07-02
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748 , A61K48/00
摘要： A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing, preventing, and treating prostate cancer and other prostate related diseases. The sequence is also useful for measuring hormone responsiveness of prostate cancer cells.
摘要翻译： 公开了在肿瘤细胞中显示前列腺特异性表达和过表达的核酸序列。 其序列和片段可用于检测，诊断，预防和治疗前列腺癌和其他前列腺相关疾病。 该序列也可用于测量前列腺癌细胞的激素反应性。
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6.发明申请METHODS OF DIAGNOSING OR TREATING PROSTATE CANCER USING THE ERG GENE, ALONE OR IN COMBINATION WITH OTHER OVER OR UNDER EXPRESSED GENES IN PROSTATE CANCER 有权使用ERG基因诊断或治疗前列腺癌的方法，单独或与前列腺癌或其他表达基因组合公开(公告)号：US20120295282A1
公开(公告)日：2012-11-22
申请号：US13534529
申请日：2012-06-27
申请人： Gyorgy Petrovics , Shiv Srivastava
发明人： Gyorgy Petrovics , Shiv Srivastava
IPC分类号： G01N33/574 , G01N21/64 , G01N33/577 , C07K16/32
CPC分类号： C12Q1/6886 , C07K16/30 , C07K16/32 , C07K2317/33 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , H05K999/99
摘要： The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.
摘要翻译： 本发明涉及致癌基因或肿瘤抑制基因以及涉及前列腺癌及其表达产物的其它基因，以及其衍生物和类似物。 提供了检测和治疗癌症的治疗组合物和方法，包括前列腺和其它相关的癌症。 还提供了通过确定至少一种前列腺癌细胞特异性基因（包括例如单独的ERG基因或LTF基因）或与至少一种前列腺癌细胞特异性基因组合的表达水平来诊断和/或预测前列腺癌的方法 的AMACR基因和DD3基因。
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公开(公告)号：US09464325B2
公开(公告)日：2016-10-11
申请号：US13534529
申请日：2012-06-27
申请人： Gyorgy Petrovics , Shiv Srivastava
发明人： Gyorgy Petrovics , Shiv Srivastava
CPC分类号： C12Q1/6886 , C07K16/30 , C07K16/32 , C07K2317/33 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , H05K999/99
摘要： The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.
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8.发明授权Prostate cancer-specific alternations in ERG gene expression and detection and treatment methods based on those alterations 有权前列腺癌特异性的ERG基因表达变化和基于这些改变的检测和治疗方法公开(公告)号：US08541169B2
公开(公告)日：2013-09-24
申请号：US12444903
申请日：2007-10-09
申请人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
发明人： Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
IPC分类号： C12Q1/68
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
摘要翻译： 本公开描述了ERG基因表达的改变。 提供参与或与前列腺癌相关的ERG同种型和ERG基因的启动子序列。 本发明还提供了检测，诊断，预后和治疗前列腺癌的治疗组合物和方法，包括用于检测以下两种或更多基因表达的生物标志物：PSA / KLK3，PMEPA1，NKX3.1，ODC1，AMD1和 尔格。
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9.发明申请Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer 审中-公开使用erg基因单独或与前列腺癌中其他过表达或低表达基因组合诊断或治疗前列腺癌的方法公开(公告)号：US20090170075A1
公开(公告)日：2009-07-02
申请号：US11579695
申请日：2005-05-06
申请人： Gyorgy Petrovics , Shiv Srivastava
发明人： Gyorgy Petrovics , Shiv Srivastava
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K16/30 , C07K16/32 , C07K2317/33 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , H05K999/99
摘要： The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.
摘要翻译： 本发明涉及致癌基因或肿瘤抑制基因以及涉及前列腺癌及其表达产物的其它基因，以及其衍生物和类似物。 提供了检测和治疗癌症的治疗组合物和方法，包括前列腺和其它相关的癌症。 还提供了通过确定至少一种前列腺癌细胞特异性基因（包括例如单独的ERG基因或LTF基因）或与至少一种前列腺癌细胞特异性基因组合的表达水平来诊断和/或预测前列腺癌的方法 的AMACR基因和DD3基因。
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公开(公告)号：US20060269546A1
公开(公告)日：2006-11-30
申请号：US11452925
申请日：2006-06-15
申请人： Shiv Srivastava , Judd Moul , Linda Xu
发明人： Shiv Srivastava , Judd Moul , Linda Xu
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30 , C07K14/72
CPC分类号： C07K14/4748 , C07K14/47
摘要： This invention relates to the androgen-regulated gene, PMEPA1, and proteins encoded by this gene, including variants and analogs thereof. Also provided are other androgen-regulated nucleic acids, a polynucleotide array containing these androgen-regulated nucleic acids, and methods of using the polynucleotide array in the diagnosis and prognosis of prostate cancer.
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