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1.发明授权Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same 失效细菌细胞提取物，其制备方法，含有其的抗肿瘤制剂和含有它的佐剂制剂
公开(公告)号：US4726947A
公开(公告)日：1988-02-23
申请号：US271647
申请日：1981-06-08
IPC分类号： A61K39/04 , A61K35/74 , A61K38/00 , A61K39/39 , A61P35/00 , A61P37/04 , C12P1/04 , A61K39/02 , A61K35/78
CPC分类号： A61K39/39 , A61K35/74 , A61K2039/55594
摘要： Cells of a microorganism, such as Mycobacterium tuberculosis, belonging to the genus Mycobacterium are disrupted in distilled water or a suitable buffer solution, and then centrifuged or filtrated to remove the cell wall residue. To the aqueous cell-free extract is added a polyvalent metal salt or an antibiotic, such as streptomycin sulfate, which acts as a flocculant to form a precipitate. The precipitate consists essentially of sugar, protein, lipid, and nucleic acid. Owing to its high antitumor and adjuvant activities as well as its slight side effects, it can be used as antitumor and adjuvant preparations.
摘要翻译： 属于分枝杆菌属的结核分枝杆菌等微生物的细胞在蒸馏水或合适的缓冲溶液中破碎，然后离心或过滤除去细胞壁残留物。 向无水细胞提取物中加入多价金属盐或抗生素，如硫酸链霉素，其作为絮凝剂形成沉淀物。 沉淀物基本上由糖，蛋白质，脂质和核酸组成。 由于其抗肿瘤和佐剂活性高，并具有轻微的副作用，可用作抗肿瘤和辅助制剂。
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2.发明授权
公开(公告)号：US4579941A
公开(公告)日：1986-04-01
申请号：US407802
申请日：1982-08-13
CPC分类号： C07H21/00
摘要： Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.
摘要翻译： 通过加热从分枝杆菌属细菌的破碎细胞分离的物质获得具有抗肿瘤活性的热变性DNA MD-011。
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3.发明授权Anti-ganglioside GD.sub.1 A monoclonal antibody MZ, MZ-producing cells and MZ-containing reagent 失效抗神经肽GD1A单克隆抗体MZ，生产MZ的细胞和含MZ的试剂
公开(公告)号：US5192662A
公开(公告)日：1993-03-09
申请号：US241291
申请日：1988-09-07
申请人： Shizuo Shimada , Daiji Iwata , Wakao Sato
发明人： Shizuo Shimada , Daiji Iwata , Wakao Sato
IPC分类号： C12N5/10 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/30 , C07K16/18 , Y10S436/813
摘要： Disclosed is a novel anti-ganglioside GD.sub.1a monoclonal antibody (MZ) which is capable of recognizing ganglioside GD.sub.1a but is practically incapable of recognizing GalCer, LacCer, Gb.sub.3, Gb.sub.4, GA.sub.1, GA.sub.2, GM.sub.2, GM.sub.3, GD.sub.1b, GT.sub.1b, GQ.sub.1b, Fuc-GM.sub.1, nLc.sub.4 and sialosyl nLc.sub.4 ; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD.sub.1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.
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