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    Method for Manufacturing an Optically Active Hydroxymethylated Compound and a Catalyst Therefore
    1.
    发明申请
    Method for Manufacturing an Optically Active Hydroxymethylated Compound and a Catalyst Therefore 有权
    因此制造光学活性羟甲基化合物和催化剂的方法

    公开(公告)号：US20080139835A1

    公开(公告)日：2008-06-12

    申请号：US11795525

    申请日：2006-01-27

    申请人： Shu Kobayashi ,  Kei Manabe

    发明人： Shu Kobayashi ,  Kei Manabe

    IPC分类号： C07F7/02 ,  B01J23/16

    CPC分类号： B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

    摘要： A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.

    摘要翻译： 由下式（式1）（式中，R 5至R 7表示）的硅烯醇酯代表氢原子，脂族烃基，单环或多环脂环族烃基 ，单环或多环芳族或芳族 - 脂族烃基或杂环基，R 5和R 7不同，R 6不是氢 原子，每个R 8可以相同或不同，表示甲基，乙基或异丙基），并使甲醛在水和有机溶剂的混合溶剂中反应， 通过混合包含手性联吡啶化合物或其对映体和Bi（OTf）3 N 3的配体获得的催化剂的存在。

    Method for aldol reaction in water
    2.
    发明授权
    Method for aldol reaction in water 失效
    水中醛醇醛反应的方法

    公开(公告)号：US07323603B2

    公开(公告)日：2008-01-29

    申请号：US10471693

    申请日：2002-03-08

    申请人： Shu Kobayashi ,  Kei Manabe

    发明人： Shu Kobayashi ,  Kei Manabe

    IPC分类号： C07C45/00

    CPC分类号： C07C45/511

    摘要： A method for aldol reaction in water, which comprises: reacting an aldehyde with a silyl enol ether in an aqueous medium in the presence of a boronic acid represented by the following general formula (1): R1R2BOH  (1) (wherein R1 and R2 are the same or different hydrocarbon groups that may contain a substituent), a surfactant, and a Brønsted acid is provided. This method for aldol reaction in water uses a catalytic amount of the boron source to give products in high yield and selectivity.

    摘要翻译： 一种在水中醛醇醛反应的方法，其包括：在下列通式（1）表示的硼酸存在下，在水性介质中使醛与甲硅烷基烯醇醚反应：<？在线式描述=“ 在线公式“end =”lead“？> R＆lt; 1＆lt; 2＆gt; BOH（1）<？in-line-formula description =”In-line Formulas“end =“尾”→（其中R 1和R 2是相同或不同的可以含有取代基的烃基），表面活性剂和布朗斯台德酸 。 这种在水中醛醇反应的方法使用催化量的硼源，以高产率和选择性产生产物。

    Method for Performing Aldol Reaction in Water
    3.
    发明申请
    Method for Performing Aldol Reaction in Water 审中-公开
    在水中进行醛醇反应的方法

    公开(公告)号：US20070238902A1

    公开(公告)日：2007-10-11

    申请号：US11587430

    申请日：2005-02-14

    申请人： Shu Kobayashi ,  Kei Manabe

    发明人： Shu Kobayashi ,  Kei Manabe

    IPC分类号： C07C45/72 ,  C07B61/00 ,  C07C49/747 ,  C07C49/835 ,  C07C49/84 ,  C07C49/83 ,  C07C327/22

    CPC分类号： C07C327/22 ,  C07C45/511 ,  C07C49/83 ,  C07C49/84 ,  C07C49/747

    摘要： An aldol reaction in an aqueous solution between an aldehyde represented by the following formula (I): R—CHO  (I) (wherein R is a hydrocarbon group which may have an substituent), and a silicon enolate represented by the following formula (II): (wherein R1 and R2 are a hydrogen atom or an aliphatic hydrocarbon group, at least one of them being an aliphatic hydrocarbon group; and R3 is a substituent selected from the group consisting of an aliphatic hydrocarbon group, an aromatic hydrocarbon group and a sulfur-containing substituent, wherein R2 and R3 may be combined with each other to form a ring) is performed so as to generate diastereoselectivity by using FeCl3, which is a low-cost Lewis acid, and a surfactant.

    摘要翻译： 在由下式（I）表示的醛之间的水溶液中的醛醇缩合反应：<？in-line-formula description =“In-line formula”end =“lead”→R-CHO（I）<αin -line-formula description =“In-line Formulas”end =“tail”？>（其中R是可以具有取代基的烃基）和由下式（II）表示的硅烯醇酯：（其中R < SUP> 1和R 2是氢原子或脂族烃基，其中至少一个是脂族烃基; R 3是 选自脂族烃基，芳族烃基和含硫取代基的取代基，其中R 2和R 3可以彼此结合成 形成环），以便通过使用作为低成本路易斯酸的FeCl 3 N和表面活性剂来产生非对映选择性。

    Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore
    5.
    发明授权
    Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore 有权
    因此制造光学活性羟甲基化化合物和催化剂的方法

    公开(公告)号：US07541307B2

    公开(公告)日：2009-06-02

    申请号：US11795525

    申请日：2006-01-27

    申请人： Shu Kobayashi ,  Kei Manabe

    发明人： Shu Kobayashi ,  Kei Manabe

    IPC分类号： B01J31/00 ,  C07C45/00 ,  C07C49/00

    CPC分类号： B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

    摘要： A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.

    摘要翻译： 由下式（式1）表示的硅烯醇化物（式中，R5〜R7表示氢原子，脂肪族烃基，单环或多环脂肪族烃基，单环或多环芳香族或芳香族 - 脂肪族烃基或杂环基，R5 和R 7不同，R 6不是氢原子，各R 8可以相同或不同，表示甲基，乙基或异丙基）和甲醛在水和有机溶剂的混合溶剂中反应 在通过混合包含手性联吡啶化合物或其对映体的配体和Bi（OTf）3）获得的催化剂存在下进行。