公开(公告)号：US20060167041A1

公开(公告)日：2006-07-27

申请号：US11385786

申请日：2006-03-22

申请人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

发明人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

IPC分类号： C07D471/02 ,  A61K31/4745

CPC分类号： A61K31/444 ,  C07D471/04

摘要： A compound represented by the following general formula (1), or a salt or hydrate thereof: [Formula 1] wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

摘要翻译： 由以下通式（1）表示的化合物或其盐或水合物：[其中R 1表示可以被取代的C 1 -C 6烷基或C 2 -C 6炔基的[式1] 或可被取代的苯基，R 2表示氢原子或C 1 -C 6烷基，R 3表示甲基或乙基，R“ R 4表示C 1 -C 6烷基，R 5表示氢原子，条件是其中R 1为未取代的C 1 -C 6烷基的化合物或 被卤素原子取代，R 2是氢原子。

公开(公告)号：US07781452B2

公开(公告)日：2010-08-24

申请号：US11385786

申请日：2006-03-22

申请人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

发明人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

IPC分类号： A61K31/444 ,  C07D471/02

CPC分类号： A61K31/444 ,  C07D471/04

摘要： A compound represented by the following general formula (1), or a salt or hydrate thereof:[Formula 1] wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

摘要翻译： 由下述通式（1）表示的化合物或其盐或水合物：[式1]其中R 1表示可以被取代的C 1 -C 6烷基或C 2 -C 6炔基，或可以是 取代基，R 2表示氢原子或C 1 -C 6烷基，R 3表示甲基或乙基，R 4表示C 1 -C 6烷基，R 5表示氢原子，条件是其中R 1为C 1 -C 6烷基 未被取代或被卤素原子取代且R 2为氢原子。

公开(公告)号：US20050272764A1

公开(公告)日：2005-12-08

申请号：US11110756

申请日：2005-04-21

申请人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

发明人： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

IPC分类号： A61K31/4439 ,  A61K31/444 ,  A61K31/4745 ,  A61P1/04 ,  A61P1/06 ,  A61P31/04 ,  C07D471/02 ,  C07D471/04

CPC分类号： A61K31/444 ,  C07D471/04

摘要： A compound represented by the following general formula (1), or a salt or hydrate thereof: wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

摘要翻译： 由以下通式（1）表示的化合物或其盐或水合物：其中R 1表示可被取代的C 1 -C 6烷基或C 2 -C 6炔基，或苯基 可以被取代的基团，R 2表示氢原子或C 1 -C 6烷基，R 3表示甲基或乙基，R 4 O >表示C 1 -C 6烷基，R 5表示氢原子，条件是其中R 1为未被取代或被卤素取代的C1-C6烷基的化合物 原子和R 2是氢原子。

公开(公告)号：US20090203911A1

公开(公告)日：2009-08-13

申请号：US12189590

申请日：2008-08-11

申请人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： C07D405/14 ,  C07D401/12

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

公开(公告)号：US08124780B2

公开(公告)日：2012-02-28

申请号：US12189590

申请日：2008-08-11

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： C07D401/12

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

公开(公告)号：US07425634B2

公开(公告)日：2008-09-16

申请号：US11520838

申请日：2006-09-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： C07D401/12

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability.Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

公开(公告)号：US20070015782A1

公开(公告)日：2007-01-18

申请号：US11403815

申请日：2006-04-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D491/14

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

公开(公告)号：US20070010542A1

公开(公告)日：2007-01-11

申请号：US11520838

申请日：2006-09-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D405/14

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

公开(公告)号：US06498159B1

公开(公告)日：2002-12-24

申请号：US09508197

申请日：2000-03-08

申请人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

发明人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

IPC分类号： A61K31502

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/28 ,  C07D237/34 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10

摘要： The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-membered amine ring substituted with a hydroxyl group is excluded.

摘要翻译： 本发明提供作为下述式表示的勃起功能障碍治疗剂的酞嗪化合物，其药理学上可接受的盐或其水合物：其中R1和R2彼此相同或不同，表示卤素原子， 可以被卤素原子取代的C1〜C4烷基，可被卤素原子或氰基取代的C1〜C4烷氧基; X表示氰基，硝基，卤素原子，可被取代的羟基亚氨基或可被取代的杂芳基; Y表示可以被取代的杂芳基，可以被取代的芳基，可以被取代的炔基，烯基，烷基，任选取代的饱和或不饱和的4-至8-元胺环，环胺化合物是 单环化合物，双环化合物或螺环化合物; l为1〜3的整数， 条件是其中l为1或2的情况，X为氰基，硝基或氯原子，R 1为氯原子，R 2为甲氧基，Y为被5或6元环取代的5-或6-元胺环 不包括羟基。

公开(公告)号：US06699870B2

公开(公告)日：2004-03-02

申请号：US10281194

申请日：2002-10-28

申请人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

发明人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

IPC分类号： A61K31502

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/28 ,  C07D237/34 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10

摘要： The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-memberred amine ring substituted with a hydroxyl group is excluded.

摘要翻译： 本发明提供作为下式表示的勃起功能障碍治疗剂的酞嗪化合物，其药理学上可接受的盐或其水合物：其中R 1和R 2彼此相同或不同， 可以被卤素原子取代的C1〜C4烷基，可被卤素原子或氰基取代的C1〜C4烷氧基; X表示氰基，硝基，卤素原子，可被取代的羟基亚氨基或可被取代的杂芳基; Y表示可以被取代的杂芳基，可以被取代的芳基，可以被取代的炔基，烯基，烷基，任选取代的饱和或不饱和的4-至8-元胺环，环胺化合物是 单环化合物，双环化合物或螺环化合物; l为1〜3的整数， 条件是其中l为1或2，X为氰基，硝基或氯原子，R 1为氯原子，R 2为甲氧基，Y为5-或6 被羟基取代的胺基环被排除。