利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.024 秒)

    Reconfigurable protein patterning using electrowetting microelectrodes
    8.
    发明授权
    Reconfigurable protein patterning using electrowetting microelectrodes 失效
    使用电润湿微电极重构蛋白图案

    公开(公告)号：US07615369B2

    公开(公告)日：2009-11-10

    申请号：US11233975

    申请日：2005-09-22

    申请人： Chih-Tin Lin ,  Amaya Frost ,  Edgar Meyhöfer ,  Katsuo Kurabayashi ,  Chao Yung Fan

    发明人： Chih-Tin Lin ,  Amaya Frost ,  Edgar Meyhöfer ,  Katsuo Kurabayashi ,  Chao Yung Fan

    IPC分类号： C12M1/34

    CPC分类号： G01N33/5438 ,  G01N33/54306

    摘要： A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called “electrowetting,” where surface wettability can dynamically be controlled by varying the voltage across the device electrodes. When an electric field is applied across the electrode layers, the surface accumulates charge and becomes hydrophilic, binding the proteins to the surface via ionic bonding. Electrically controlling the amount of the surface charge permits controlled protein surface affinity. The device provides a means for reconfigurable protein patterning.

    摘要翻译： 提供了由涂覆有蛋白质非粘附层的电容器微电极阵列组成的蛋白质图案形成电极装置。 电极的操作基于称为“电润湿”的现象，其中通过改变器件电极两端的电压来动态地控制表面润湿性。 当跨越电极层施加电场时，表面积累电荷并变成亲水性，通过离子键将蛋白质结合到表面。 电子控制表面电荷的量允许控制的蛋白质表面亲和力。 该装置提供了可重构蛋白质图案化的手段。

    Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities
    9.
    发明申请
    Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities 有权
    具有垂直扫描能力的目标双轴共聚焦成像仪

    公开(公告)号：US20110125029A1

    公开(公告)日：2011-05-26

    申请号：US12916159

    申请日：2010-10-29

    申请人： Thomas D. Wang ,  Katsuo Kurabayashi ,  Kenn Oldham ,  Zhen Qiu

    发明人： Thomas D. Wang ,  Katsuo Kurabayashi ,  Kenn Oldham ,  Zhen Qiu

    IPC分类号： A61B6/00

    CPC分类号： G02B26/101 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/4255 ,  A61B2503/40 ,  G01N21/6458 ,  G02B21/0028 ,  G02B21/0036 ,  G02B21/0076 ,  G02B26/0841

    摘要： An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.

    摘要翻译： 描述了可用作用于实时三维光学成像的显微镜系统的光学装置。 该装置包括使用双轴共焦结构以允许垂直于样品表面（例如，组织表面）的垂直扫描的微型光纤，生物质内探针显微镜。 光学装置可以使用离轴照明和光的收集来实现具有深层组织穿透的亚细胞分辨率。 光学装置可以被用作使用荧光标记的肽来检测小癌动物模型中由结肠和乳腺肿瘤的上皮和/或内皮上调的细胞表面靶的整合分子成像策略的一部分。