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    Compositions and methods relating to ovarian specific genes and proteins
    4.
    发明申请
    Compositions and methods relating to ovarian specific genes and proteins 审中-公开
    与卵巢特异性基因和蛋白质有关的组成和方法

    公开(公告)号：US20050148008A1

    公开(公告)日：2005-07-07

    申请号：US11057516

    申请日：2005-02-14

    申请人： Susana Salceda ,  Roberto Macina ,  Ping Hu ,  Herve Recipon ,  Kalpana Karra ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu

    发明人： Susana Salceda ,  Roberto Macina ,  Ping Hu ,  Herve Recipon ,  Kalpana Karra ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  C07K14/72 ,  C07K16/30

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.

    摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

    Compositions and methods relating to breast specific genes and proteins
    5.
    发明申请
    Compositions and methods relating to breast specific genes and proteins 审中-公开
    与乳腺特异性基因和蛋白质有关的组成和方法

    公开(公告)号：US20050048559A1

    公开(公告)日：2005-03-03

    申请号：US10958863

    申请日：2004-10-05

    申请人： Susana Salceda ,  Roberto Macina ,  Herve Recipon ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu

    发明人： Susana Salceda ,  Roberto Macina ,  Herve Recipon ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  G01N33/574 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/57415

    摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

    摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。