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    Process for the preparation of immunogammaglobulin using trithionate compounds
    2.
    发明授权
    Process for the preparation of immunogammaglobulin using trithionate compounds 失效
    使用三硫酸化合物制备免疫球蛋白的方法

    公开(公告)号：US4347179A

    公开(公告)日：1982-08-31

    申请号：US233611

    申请日：1981-01-23

    申请人： Syoji Ono ,  Shuzi Miura ,  Tsunemasa Yoshida

    发明人： Syoji Ono ,  Shuzi Miura ,  Tsunemasa Yoshida

    IPC分类号： A61K38/00 ,  C07K16/00 ,  C07K16/06 ,  A61K39/395 ,  A61K39/44 ,  C07G7/00

    CPC分类号： C07K16/065 ,  C07K16/00 ,  A61K38/00

    摘要： A process for the preparation of immunogammaglobulin derivatives that can be administered by intravenous injection because of their reduced anticomplement activity level in which the reaction of human immunogammaglobulin with a compound capable of forming trithionate ion and another compound capable of forming sulfite ion in water is carried out in water to cleave the interchain disulfide bonds in said immunogammaglobulin and simultaneously the sulfur atoms cleaved are S-sulfonated.

    摘要翻译： PCT No.PCT / JP79 / 00131 Sec。 371日期1981年1月23日 102（e）日期1981年1月22日PCT提交1979年5月23日PCT公布。 出版物WO80 / 02561 日期：1980年11月27日。一种制备免疫球蛋白衍生物的方法，其可以通过静脉内注射施用，因为其抗人补体活性水平降低，其中人免疫球蛋白与能够形成三硫酸离子的化合物和能够形成三硫酸离子的化合物的反应 水中的亚硫酸根离子在水中进行以切割所述免疫γ-球蛋白中的链间二硫键，同时裂解的硫原子被S-磺化。

    Method of the production of immunoglobulin having high content of monomer
    3.
    发明授权
    Method of the production of immunoglobulin having high content of monomer 失效
    生产具有高含量单体的免疫球蛋白的方法

    公开(公告)号：US4384993A

    公开(公告)日：1983-05-24

    申请号：US176689

    申请日：1980-08-08

    申请人： Tetsuro Sato ,  Akinobu Funatsu ,  Komei Ohashi ,  Shoji Ono ,  Tsunemasa Yoshida

    发明人： Tetsuro Sato ,  Akinobu Funatsu ,  Komei Ohashi ,  Shoji Ono ,  Tsunemasa Yoshida

    IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K14/435 ,  C07K16/06 ,  C07G7/00

    CPC分类号： C07K16/065 ,  Y10S530/83 ,  Y10S530/831

    摘要： A method of the production of immunoglobulin having a high content of monr from immunoglobulin-containing materials by a fractionation method, which comprises carrying out the fractionation in the presence of a water-soluble, basic nitrogen-containing organic compound having a dissociation constant (pKb) of 7 or less or an acid addition salt thereof, and thereby inhibiting by-production of undesirable aggregated molecules. The immunoglobulin has a high content of monomer and contains no or little aggregated molecules and hence can be used as a medicine in immune prophylaxis and immunotherapy without undesirable side effects and can be administered by intraveneous route, and further, is useful for the preparation of chemically treated immunoglobulin having a high content of monomer.

    摘要翻译： 一种通过分级方法生产具有高含量含免疫球蛋白的材料的免疫球蛋白的方法，其包括在具有解离常数（pKb）的水溶性碱性含氮有机化合物的存在下进行分级分离 ）为7以下或其酸加成盐，从而抑制副产物不合格聚集的分子。 免疫球蛋白具有高含量的单体并且不含或少量聚集的分子，因此可用作免疫预防和免疫治疗中的药物而没有不希望的副作用，并且可以通过侵入途径施用，并且还可用于制备化学 处理的具有高含量单体的免疫球蛋白。

    Artificial lung surfactant and remedy for respiratory distress syndrome containing it as active principle
    5.
    发明授权
    Artificial lung surfactant and remedy for respiratory distress syndrome containing it as active principle 失效
    人造肺表面活性剂及其治疗呼吸窘迫综合征，含有它作为活性成分

    公开(公告)号：US4973582A

    公开(公告)日：1990-11-27

    申请号：US056298

    申请日：1987-05-29

    申请人： Tsunemasa Yoshida ,  Masayuki Kokubo ,  Yoshinori Takada ,  Tsutomu Kobayashi

    发明人： Tsunemasa Yoshida ,  Masayuki Kokubo ,  Yoshinori Takada ,  Tsutomu Kobayashi

    IPC分类号： A61K31/20 ,  A61K31/23 ,  A61K31/66 ,  A61K31/675 ,  A61K31/685

    CPC分类号： A61K31/685

    摘要： An artificial lung surfactant comprising (a) phosphatidyl choline and cardiolipin and/or phosphatidyl choline and cardiolipin and/or phosphatidyl glycerol in addition as phospholipids, wherein the content of the pospholipids is 80 to 95 wt % of the whole composition, (b) neutral lipids, wherein the content is 5 to 20 wt % of the whole composition, and (c) fatty acids, wherein the content is 0 to 10 wt % of the whole composition, and a remedy for respiratory distress syndrome containing the surfactant as an active principle.

    摘要翻译： 一种人造肺表面活性剂，其包含（a）磷脂酰胆碱和心磷脂和/或磷脂酰胆碱以及心磷脂和/或磷脂酰甘油作为磷脂，其中磷脂的含量为整个组合物的80-95重量％，（b）中性 脂肪，其中含量为整个组合物的5至20重量％，和（c）含量为整个组合物的0至10重量％的脂肪酸​​，以及含有作为活性成分的表面活性剂的呼吸窘迫综合征的补救措施 原理。

    S-Sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
    6.
    发明授权
    S-Sulfonated immunoglobulin composition having a high monomer content and a process for production thereof 失效
    具有高单体含量的S-磺化免疫球蛋白组合物及其制备方法

    公开(公告)号：US4360457A

    公开(公告)日：1982-11-23

    申请号：US182053

    申请日：1980-08-28

    申请人： Syoji Ono ,  Yuji Fukumoto ,  Tsunemasa Yoshida

    发明人： Syoji Ono ,  Yuji Fukumoto ,  Tsunemasa Yoshida

    IPC分类号： A61K38/00 ,  C07K16/06 ,  C07G7/00

    CPC分类号： C07K16/065 ,  A61K38/00 ,  Y10S530/831

    摘要： The present invention is directed to an S-sulfonated immunoglobulin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7.There is also provided a process for producing an S-sulfonated immunoglobulin composition having a high monomer content, which comprises contacting an S-sulfonated immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of the water-soluble acid addition salt, or reacting an immunoglobulin in aqueous solution with a compound capable of yielding a sulfite ion in water and an oxidizing agent in the presence of about 1 to about 600% by weight, based on the immunoglobulin, of the water-soluble acid addition salt.

    摘要翻译： 本发明涉及S-磺化免疫球蛋白组合物，其包含S-磺化免疫球蛋白和作为聚集防止剂或聚集体解离剂，其为约1-约600重量％，基于S-磺化的 免疫球蛋白，在分子中含有一个或多个碱性氮原子的碱性含氮有机化合物的水溶性酸加成盐和任选的羧基数量小于碱性氮原子，并且在25℃下具有pKb 还提供了一种制备具有高单体含量的S-磺化免疫球蛋白组合物的方法，该方法包括使S-磺化免疫球蛋白在水溶液中的含量为约1-约600重量％，基于重量 的S-磺化免疫球蛋白，水溶性酸加成盐，或使水溶液中的免疫球蛋白与能够产生亚硫酸盐的化合物反应 在水和氧化剂中，以约1至约600重量％（以免疫球蛋白为基准）存在水溶性酸加成盐。

    Immunoglobulin composition having a high monomer content, and process for production thereof
    7.
    发明授权
    Immunoglobulin composition having a high monomer content, and process for production thereof 失效
    具有高单体含量的免疫球蛋白组合物及其生产方法

    公开(公告)号：US4362661A

    公开(公告)日：1982-12-07

    申请号：US175739

    申请日：1980-08-06

    申请人： Syoji Ono ,  Yuji Fukumoto ,  Tsunemasa Yoshida

    发明人： Syoji Ono ,  Yuji Fukumoto ,  Tsunemasa Yoshida

    IPC分类号： A61K39/395 ,  C07G7/00

    CPC分类号： A61K39/39591 ,  Y10S530/831

    摘要： An immunoglobulin composition comprising an immunoglobulin, and as an aggregation preventing agent or an aggregate dissociating agent for the immunoglobulin, about 1 to about 600% by weight, based on the weight of the immunoglobulin, of a water-soluble acid additive salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups in smaller number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7; and a method for producing an immunoglobulin composition having a high monomer content, which comprises contacting an immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the immunoglobulin, of a water-soluble acid addition salt thereby to prevent aggregation of the monomer of the immunoglobulin, and when the immunoglobulin contains aggregated molecules, dissociating the aggregated molecules into monomers, and thereafter, if desired, lyophilizing the resulting product.

    摘要翻译： 约1至约600重量％，基于免疫球蛋白重量的免疫球蛋白，以及用作免疫球蛋白的聚集防止剂或聚集体解离剂的免疫球蛋白组合物，包含碱性 在分子中含有一个或多个碱性氮原子的含氮有机化合物和任选的羧基数量小于碱性氮原子，并且25℃下的pKb不大于7; 以及一种制备具有高单体含量的免疫球蛋白组合物的方法，该方法包括使水溶液中的免疫球蛋白与约1至约600重量％（以该免疫球蛋白重量为基准计）的水溶性酸加成盐接触，从而 防止免疫球蛋白的单体的聚集，并且当免疫球蛋白含有聚集的分子时，将聚集的分子解离成单体，然后如果需要，将所得产物冻干。