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公开(公告)号:US09879087B2
公开(公告)日:2018-01-30
申请号:US14987432
申请日:2016-01-04
IPC分类号: A61K39/00 , C07K16/30 , A61K47/48 , A61K47/02 , C07K16/44 , A61K9/00 , A61K47/12 , A61K39/395
CPC分类号: C07K16/30 , A61K9/0019 , A61K39/39558 , A61K39/39591 , A61K47/02 , A61K47/12 , A61K47/6803 , A61K47/6851 , A61K47/6897 , A61K2039/505 , C07K16/44 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.
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公开(公告)号:US20170306046A1
公开(公告)日:2017-10-26
申请号:US15526593
申请日:2015-11-12
发明人: Ana Paula Galvao daSilva , Darius Ghaderi , Mai Zhang , Kristan Meetze , Julie DeSander , Jeffrey Behrens , David A. Eavarone , Jillian M. Prendergast , Alexey Alexandrovich Lugovskoy
IPC分类号: C07K16/30 , C07K16/00 , G01N33/574
CPC分类号: G01N33/57492 , A61K47/6817 , A61K47/6851 , C07K16/005 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.
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公开(公告)号:US20160130356A1
公开(公告)日:2016-05-12
申请号:US14987432
申请日:2016-01-04
发明人: Julie DeSander , Jeffrey Behrens
IPC分类号: C07K16/30 , A61K39/395 , A61K47/02 , A61K47/48 , A61K47/12
CPC分类号: C07K16/30 , A61K9/0019 , A61K39/39558 , A61K39/39591 , A61K47/02 , A61K47/12 , A61K47/6803 , A61K47/6851 , A61K47/6897 , A61K2039/505 , C07K16/44 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.
摘要翻译: 本发明提供了聚糖相互作用的抗体和用于生产可用于治疗和预防人类疾病(包括癌症)的聚糖相互作用的抗体的方法。 这样的聚糖相互作用抗体包括单克隆抗体,衍生物及其片段,以及包含它们的组合物和试剂盒。 还提供了使用聚糖相互作用抗体靶向细胞并治疗疾病的方法。
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公开(公告)号:US20180327509A1
公开(公告)日:2018-11-15
申请号:US15775410
申请日:2016-11-10
发明人: David A. Eavarone , Jillian M. Prendergast , Jeffrey Behrens , Alexey Alexandrovich Lugovskoy , Daniel T. Dransfield
CPC分类号: C07K16/3084 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K2039/505 , A61K2039/572 , C07K16/3092 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include humanized antibodies, derivatives and fragments thereof as well as related compositions and kits. Methods of using glycan-interacting antibodies for treatment and diagnosis are included.
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公开(公告)号:US20160264684A1
公开(公告)日:2016-09-15
申请号:US15028360
申请日:2014-10-10
发明人: Ana Paula Galvao da Silva , Mai Zhang , Darius Ghaderi , Intan Purnajo , Julie DeSander , Jeffrey Behrens
CPC分类号: C07K16/44 , A61K9/0019 , A61K47/6835 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/732 , C07K2317/92
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives and fragments thereof as well as compositions and kits comprising them.
摘要翻译: 本发明提供了聚糖相互作用的抗体和用于生产可用于治疗和预防人类疾病(包括癌症)的聚糖相互作用的抗体的方法。 这样的聚糖相互作用抗体包括单克隆抗体,其衍生物和片段,以及包含它们的组合物和试剂盒。
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公开(公告)号:US20190031780A1
公开(公告)日:2019-01-31
申请号:US16073349
申请日:2017-01-27
发明人: David A. Eavarone , Jeffrey Behrens , Jillian M. Prendergast , Bo R. Rueda , Rosemary Foster , Kristen D. Starbuck
IPC分类号: C07K16/44 , A61K31/337 , A61K31/555 , A61K39/395 , A61K47/68 , G01N33/574 , A61P35/00
摘要: Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells.
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公开(公告)号:US20170305950A1
公开(公告)日:2017-10-26
申请号:US15518179
申请日:2015-10-09
发明人: Ana Paula Galvao da Silva , Mai Zhang , Darius Ghaderi , Julie DeSander , Jeffrey Behrens , Jillian M. Prendergast
IPC分类号: C07H15/04 , G01N33/574 , C40B40/12 , G01N33/68
CPC分类号: C07H15/04 , C40B40/12 , G01N33/57484 , G01N33/6854 , G01N2400/12 , G01N2400/38
摘要: The invention provides methods and tools, for example, glycan arrays, for the analysis of glycans and anti-glycan antibodies. Embodiments of the invention may be used to detect proteins, antibodies, diseases and/or pathogenic agents. In other embodiments, methods of the invention are used to develop or optimize arrays and antibodies.
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公开(公告)号:US20190276541A1
公开(公告)日:2019-09-12
申请号:US16462075
申请日:2017-11-17
摘要: The present disclosure provides antibodies with T cell-interacting regions and/or glycan-interacting regions. Bispecific antibodies capable of recruiting T cells to cancer cells are also provided, including bispecific antibodies capable of recruiting T cells to cancer cells expressing sialyl Tn (STn). The present disclosure also includes methods for killing cells by targeting them with antibodies having T cell-interacting regions.
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公开(公告)号:US20180280504A1
公开(公告)日:2018-10-04
申请号:US15518214
申请日:2015-10-09
发明人: Ana Paula Galvao da Silva , Julie DeSander , Jeffrey Behrens , Darius Ghaderi , Mai Zhang , Kristan Meetze
IPC分类号: A61K39/395 , C07K16/30 , C07K16/44
摘要: The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them.
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公开(公告)号:US20160106799A1
公开(公告)日:2016-04-21
申请号:US14893971
申请日:2014-05-29
发明人: Mai Zhang , Darius Ghaderi , Jeffrey Behrens , Julie DeSander , Ajit Varki
CPC分类号: A61K38/018 , A23L13/42 , A23L15/30 , A23L33/10 , A23L33/18 , A23L33/19 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/7012 , A61K35/20 , A61K35/57 , A61K45/06 , G01N33/5308 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/5409 , G01N2333/5412 , G01N2333/57 , G01N2800/52 , G01N2800/7095 , A61K2300/00
摘要: Embodiments of the present invention provide compositions and methods for the modulation of sialic acid levels. In some embodiments, compositions disclosed herein comprise nutraceuticals as functional agents.
摘要翻译: 本发明的实施方案提供了调节唾液酸水平的组合物和方法。 在一些实施方案中,本文公开的组合物包含作为功能剂的营养药物。
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