公开(公告)号：US20200031889A1

公开(公告)日：2020-01-30

申请号：US16599696

申请日：2019-10-11

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden ,  Eric Cowden

IPC: C07K14/475 ,  C12Q1/37 ,  G01N33/68

Abstract: A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.

公开(公告)号：US20160074857A1

公开(公告)日：2016-03-17

申请号：US14784757

申请日：2014-04-09

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： Jay J. Li ,  Normand P. Desmarais ,  James E. Rasmussen ,  Eric Cowden

IPC: B01L3/02

CPC classification number: B01L3/0265 ,  B01L3/0241 ,  B01L3/0268 ,  B01L7/50 ,  B01L2200/16 ,  B01L2300/0838 ,  B01L2300/1894 ,  B01L2400/02 ,  B01L2400/021 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/082 ,  G01N2035/1034

Abstract: A liquid deposition system comprises a liquid delivery assembly including a dispensing probe having a sidewall including a first end having a liquid port and a second end having a tip, and a flow path opening at the tip and fluidly connected with the liquid port. The system includes a gas injection assembly with a manifold having a gas nozzle, a nozzle opening, and a gas port, the gas nozzle configured to eject a substantially laminar gas stream so that the gas stream travels through a travel path, the tip of the dispensing probe extending into the travel path. The liquid port is fluidly connectable with a liquid source and the gas port is fluidly connectable with a pressurized gas source, so that a liquid micro droplet is formed at the tip. The laminar gas stream separates the micro droplet from the tip and carries it through the travel path.

Abstract translation: 液体沉积系统包括液体输送组件，其包括具有侧壁的分配探针，该侧壁包括具有液体端口的第一端和具有尖端的第二端，以及在尖端处开口并与液体端口流体连接的流路。 该系统包括具有歧管的气体注射组件，其具有气体喷嘴，喷嘴开口和气体端口，气体喷嘴构造成喷射基本上层流的气流，使得气流通过行进路径行进， 分配探针延伸到行进路径中。 液体端口可与液体源流体连接，并且气体端口可与加压气体源流体连接，从而在尖端处形成液体微滴。 层流气流将微滴与尖端分离，并将其运送通过行进路径。

公开(公告)号：US10472403B2

公开(公告)日：2019-11-12

申请号：US15535964

申请日：2015-12-23

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden ,  Eric Cowden

IPC: C12N9/50 ,  A61K38/48 ,  C07K14/475 ,  C12Q1/37 ,  G01N33/68

Abstract: A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.

公开(公告)号：US20170369544A1

公开(公告)日：2017-12-28

申请号：US15535964

申请日：2015-12-23

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： David Ledden ,  Eric Cowden

IPC: C07K14/475 ,  C12Q1/37 ,  G01N33/68

Abstract: A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.