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公开(公告)号:US20170120164A1
公开(公告)日:2017-05-04
申请号:US15318898
申请日:2015-06-16
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01D19/00
CPC classification number: B01D19/0031 , B01D19/0063
Abstract: A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. A porous membrane is disposed on a degassing area of the fluidic device for removing gas (such as, for example, bubbles) contained in a liquid. A fluid control device monitors a pressure profile indicating a pressure in the fluidic device over time and applies a pressure differential between two sides of the membrane when activated. The membrane is permeable to gas in the fluidic device and is impermeable to liquids through the pores under the pressure differential. The disclosed method enables degassing large volume of gas at a high flow rate and provides a bubble free filling in a fluidic device which is critical to precision sample metering, mixing, fluid control, reaction, and detection, etc.
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公开(公告)号:US20160318019A1
公开(公告)日:2016-11-03
申请号:US15206669
申请日:2016-07-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: David J. Ledden , Dafeng Chen , James E. Rasmussen
CPC classification number: B01L3/502753 , B01L3/502715 , B01L3/502738 , B01L2200/0605 , B01L2200/14 , B01L2200/142 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/161 , B01L2400/0688 , B01L2400/084 , G01N1/30
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
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公开(公告)号:US20160038938A1
公开(公告)日:2016-02-11
申请号:US14775338
申请日:2014-03-13
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor: Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01L3/00
CPC classification number: B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/523 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , F16K99/003 , F16K2099/008 , F16K2099/0084
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
Abstract translation: 微流体产品袋组件可用于微流体芯片。 微流体产品袋可以包括围绕内室的袋,并且具有破裂部分和位于内室内的内膜。 内膜可以将内室分离成第一腔和第二腔。 试剂可以定位在第一腔和/或第二腔内。 微流体产品袋组件还可以包括破裂结构。 破裂结构可以被配置为选择性地破坏微流体产品袋的破裂部分。
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公开(公告)号:US20150099310A1
公开(公告)日:2015-04-09
申请号:US14398259
申请日:2013-05-01
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: James E. Rasmussen
IPC: G01N1/28
CPC classification number: G01N1/28 , B01L3/502715 , B01L3/565 , B01L2200/023 , B01L2300/0816 , B01L2300/123 , Y10T436/2575
Abstract: A sample port system/device associated with a fluid collection device is provided and is configured to receive fluid-containing devices of varying diameters. A method of improving the work flow and safety involved in acquiring and/or testing fluid samples using such sample port system/device is also provided.
Abstract translation: 提供与流体收集装置相关联的样品端口系统/装置,并且构造成接收不同直径的含有流体的装置。 还提供了一种改进使用这种样品端口系统/装置获取和/或测试流体样品的工作流程和安全性的方法。
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公开(公告)号:US11235321B2
公开(公告)日:2022-02-01
申请号:US16598363
申请日:2019-10-10
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: Dafeng Chen , James E. Rasmussen , Manish Deshpande
IPC: B01L3/00
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
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公开(公告)号:US10281373B2
公开(公告)日:2019-05-07
申请号:US15643024
申请日:2017-07-06
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: James E. Rasmussen
Abstract: A sample port system/device associated with a fluid collection device is provided and is configured to receive fluid-containing devices of varying diameters. A method of improving the work flow and safety involved in acquiring and/or testing fluid samples using such sample port system/device is also provided.
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公开(公告)号:US10105701B2
公开(公告)日:2018-10-23
申请号:US15206669
申请日:2016-07-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: David J. Ledden , Dafeng Chen , James E. Rasmussen
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
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公开(公告)号:US20170299480A1
公开(公告)日:2017-10-19
申请号:US15643024
申请日:2017-07-06
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: James E. Rasmussen
CPC classification number: G01N1/28 , B01L3/502715 , B01L3/565 , B01L2200/023 , B01L2300/0816 , B01L2300/123 , Y10T436/2575
Abstract: A sample port system/device associated with a fluid collection device is provided and is configured to receive fluid-containing devices of varying diameters. A method of improving the work flow and safety involved in acquiring and/or testing fluid samples using such sample port system/device is also provided.
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公开(公告)号:US09416776B2
公开(公告)日:2016-08-16
申请号:US14776172
申请日:2014-03-13
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: David J. Ledden , Dafeng Chen , James E. Rasmussen
IPC: B01L3/00 , B01L3/02 , G01N33/00 , G01N15/06 , G01N33/48 , F04B13/00 , F04B17/03 , G01N35/10 , B05B1/02
CPC classification number: F04B13/00 , B01L3/502738 , B01L3/502753 , B01L2200/0652 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/161 , B01L2400/0688 , B01L2400/084 , B05B1/02 , F04B17/03 , G01N35/1095
Abstract: A microfluidic distributing device having a plurality of microchannels for the analysis of a fluid sample (such as blood). The microfluidic distributing device has a fluid sample entry port from which subsamples of the fluid sample are distributed to the plurality of microchannels in which fluid subsamples are treated for analysis by test devices.
Abstract translation: 具有用于分析流体样品(例如血液)的多个微通道的微流体分配装置。 微流体分配装置具有流体样品入口端口,流体样品的子样本从该流体样本入口端口分配到多个微通道,在该微通道中流体子样品被处理以供测试装置分析。
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公开(公告)号:US20200038855A1
公开(公告)日:2020-02-06
申请号:US16598363
申请日:2019-10-10
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor: Dafeng Chen , James E. Rasmussen , Manish Deshpande
Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
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