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公开(公告)号：US12025549B2
公开(公告)日：2024-07-02
申请号：US17414155
申请日：2019-05-13
IPC分类号： G01N15/12 , B01L3/00 , B81B7/02 , G01N15/10 , G01N15/1031 , G01N33/543
CPC分类号： G01N15/12 , B01L3/502761 , B81B7/02 , G01N15/1023 , G01N15/1031 , G01N33/54386 , B01L2200/025 , B01L2200/0652 , B01L2200/0663 , B01L2300/0645 , B01L2300/0663 , B01L2300/0829 , B01L2300/14 , B01L2400/02 , B01L2400/0487 , G01N2015/1006 , G01N2015/1028
摘要： A system includes a microchannel analysis region, a first fluid actuation device, a second fluid actuation device, a sensor, and a controller. The first fluid actuation device is at a first end of the microchannel analysis region. The second fluid actuation device is at a second end of the microchannel analysis region opposite to the first end. The sensor is within the microchannel analysis region between the first fluid actuation device and the second fluid actuation device. The sensor measures an impedance of a fluid within the microchannel analysis region. The controller activates the first fluid actuation device to generate a first pressure wave in the fluid and activates the second fluid actuation device to generate a second pressure wave in the fluid. The first pressure wave and the second pressure wave converge at the sensor.
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公开(公告)号：US20240182849A1
公开(公告)日：2024-06-06
申请号：US18503723
申请日：2023-11-07
发明人： Yih Yang Chen , Kaveh Milaninia , Li Sun
CPC分类号： C12N5/0012 , B01L3/502792 , B01L2400/02
摘要： Disclosed are methods and microfluidic devices for successfully co-encapsulating two or more cells in a high-throughput, high efficiency manner. Cells are organized into two or more ordered streams flowing through separate microchannels of the microfluidic device. Cells in ordered streams are sufficiently spaced such that at a junction of the microfluidic device, single droplets are generated that include exactly one cell from the first ordered stream of cells and at least one cell from the second ordered stream of cells. Single droplets including two or more cells are useful for performing assays (e.g., high throughput cell-cell interaction assays).
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公开(公告)号：US11998912B2
公开(公告)日：2024-06-04
申请号：US17954000
申请日：2022-09-27
发明人： Tza-Huei Jeff Wang , Kuangwen Hsieh , Yi-Fan Frank Hsieh , Aniruddha Mrithinjay Kaushik , Fangchi Shao , Pengfei Zhang
CPC分类号： B01L3/502738 , B25J9/1697 , B01L2300/0636 , B01L2300/0883 , B01L2400/02 , B01L2400/049 , B01L2400/0666
摘要： A tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet microfluidic chip; a valve control system connected to the tubing-free, sample-to-droplet microfluidic chip; a vacuum system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip; and a droplet formation pressure system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip. A microfluidic chip for a tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet interface section; a droplet mixing section in fluid connection with the tubing-free, sample-to-droplet interface section to received droplets therefrom; an incubation section in fluid connection with the droplet mixing section to receive droplets therefrom; and a detection section in fluid connection with the incubation section to receive droplets therefrom.
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公开(公告)号：US20240139734A1
公开(公告)日：2024-05-02
申请号：US18132492
申请日：2023-04-10
发明人： Chung-Er Huang , Sheng-Wen Chen , Hsin-Cheng Ho , GUANG-CI YE
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2200/021 , B01L2300/0672 , B01L2300/0819 , B01L2400/02 , B01L2400/0439 , B01L2400/0481
摘要： A biological particle enrichment apparatus and a pico-droplet generator thereof are provided. The pico-droplet generator includes a container, a hollow needle connected to the container, a first piezoelectric member disposed on the container, and a second piezoelectric member disposed on the hollow needle. The container can receive a liquid specimen having biological particles. The hollow needle and the container are fluid communicated with each other, and an inner diameter of the container is within a range from 5 times to 30 times of an inner diameter of the hollow needle. The first piezoelectric member is annularly disposed on a surrounding lateral side of the container, and enables the biological particles in the container to move along a direction away from the surrounding lateral side by vibrating the container. The second piezoelectric member can squeeze the hollow needle, so that the liquid specimen flows outwardly to form a pico-droplet.
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公开(公告)号：US09833779B2
公开(公告)日：2017-12-05
申请号：US14826749
申请日：2015-08-14
申请人： bioMerieux, Inc.
CPC分类号： B01L3/0237 , B01L3/021 , B01L3/0268 , B01L3/0275 , B01L2200/146 , B01L2300/0627 , B01L2300/0681 , B01L2400/02 , G01N35/00623 , G01N35/0099 , G01N35/10 , G01N35/1009 , G01N2035/1018 , G01N2035/103
摘要： This invention relates to methods, systems, and computer program products for detecting pipette tip integrity.
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公开(公告)号：US20170315024A1
公开(公告)日：2017-11-02
申请号：US15494045
申请日：2017-04-21
发明人： Liqiu WANG , Xin TANG
CPC分类号： G01N1/14 , B01L3/0244 , B01L3/56 , B01L2300/0819 , B01L2400/02 , B01L2400/0478
摘要： An apparatus and method are provided for rapid and precise manipulation and transfer of tiny liquid droplets. by dynamically introducing microstructures with relatively high surface energy to a non-wettable surface, which surface has in-situ switchable adhesion to liquid droplets. By penetrating microstructures on the background surface, the chemical property of the surface is locally modified. Capillary bridges will form between microstructures and liquid droplets which lead to high adhesive forces. When the microstructures are retracted, the capillary bridges either pinch-off or recede, which drastically reduces the adhesion. With proper chemical modification, the surface can either manipulate a liquid droplet in air or in an immiscible carrier liquid. Tiny droplets with volumes down to nanoliter scale can be prepared and dispensed by using the surface.
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7.发明授权公开(公告)号：US09795959B2
公开(公告)日：2017-10-24
申请号：US14826736
申请日：2015-08-14
申请人： bioMerieux, Inc.
CPC分类号： B01L3/0237 , B01L3/021 , B01L3/0268 , B01L3/0275 , B01L2200/146 , B01L2300/0627 , B01L2300/0681 , B01L2400/02 , G01N35/00623 , G01N35/0099 , G01N35/10 , G01N35/1009 , G01N2035/1018 , G01N2035/103
摘要： This invention relates to methods, systems, and computer program products for verifying dispensing of a fluid from a pipette.
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公开(公告)号：US09533302B2
公开(公告)日：2017-01-03
申请号：US13416485
申请日：2012-03-09
CPC分类号： B01L3/0293 , B01L3/0268 , B01L2200/028 , B01L2200/061 , B01L2200/0642 , B01L2200/143 , B01L2200/147 , B01L2400/02 , B01L2400/0439 , B01L2400/0442 , C12M41/48
摘要： A fluid cartridge has a bottle to retain a volume of fluid. An ejector chip resides in fluid communication with the bottle and causes ejection of fluid upon activation of fluid ejectors. Control logic coordinates ejector activation with dose control logic and temperature control circuitry. The dose control logic pre-specifies an amount of fluid to be ejected and prevents further ejection upon reaching the amount. Meanwhile, the temperature control circuit inhibits any ejection until a temperature of the fluid is within a predefined acceptable range. Bottle modularity, fluid dispense-areas and group-control of the ejectors facilitate certain designs.
摘要翻译： 流体盒具有保持一定体积的流体的瓶子。 喷射器芯片与瓶子流体连通，并且在激活流体喷射器时导致流体喷出。 控制逻辑用剂量控制逻辑和温度控制电路协调喷射器激活。 剂量控制逻辑预先规定要喷射的流体的量，并且防止在达到该量时进一步喷射。 同时，温度控制电路阻止任何喷射，直到流体的温度在预定的可接受范围内。 瓶模块性，流体分配区域和喷射器的组控制有助于某些设计。
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公开(公告)号：US20160305888A1
公开(公告)日：2016-10-20
申请号：US15191573
申请日：2016-06-24
IPC分类号： G01N21/78 , B01L3/00 , G01N33/543
CPC分类号： G01N21/78 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2300/0681 , B01L2300/0825 , B01L2300/0864 , B01L2300/0887 , B01L2400/02 , B01L2400/0406 , C12Q1/001 , G01N33/54366 , G01N33/54373 , G01N33/558
摘要： The present invention relates to a test system or assay system (detection system) and to a test method, preferably in use in the point-of-care (PoC) field.
摘要翻译： 本发明涉及一种测试系统或测定系统（检测系统）以及优选用于护理点（PoC）领域的测试方法。
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公开(公告)号：US20150338373A1
公开(公告)日：2015-11-26
申请号：US14817573
申请日：2015-08-04
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： G01N27/44743 , B01J4/008 , B01J2219/00315 , B01J2219/0036 , B01J2219/00418 , B01J2219/00653 , B01L3/0241 , B01L3/0268 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/02 , B01L2400/0409 , B01L2400/0427
摘要： A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting.
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