公开(公告)号：US06719750B2

公开(公告)日：2004-04-13

申请号：US09888092

申请日：2001-06-22

申请人： Signe Erickson Varner ,  Eugene DeJuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

发明人： Signe Erickson Varner ,  Eugene DeJuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

IPC分类号： A61F922

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 可以允许的治疗剂递送装置特别适合于将治疗剂递送到有限的进入区域，例如眼睛的后室和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选输送装置还包括包含一个或多个物质的非线性形状的身体构件体和用于将一种或多种物质从非线性形状的身体构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US08096972B2

公开(公告)日：2012-01-17

申请号：US10740698

申请日：2003-12-19

申请人： Sign Erickson Varner ,  Eugene Dejuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

发明人： Sign Erickson Varner ,  Eugene Dejuan, Jr. ,  Terry Shelley ,  Aaron Christopher Barnes ,  Mark Humayun

IPC分类号： A61M31/00

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： A therapeutic agent delivery device that is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 一种治疗剂递送装置，其特别适用于将治疗剂递送至限制的进入区域，例如眼睛后内腔和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选的输送装置还包括包含一个或多个物质的非线性形状的本体构件和用于将一种或多种物质从非线性体状构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US20050059956A1

公开(公告)日：2005-03-17

申请号：US10823089

申请日：2004-04-12

申请人： Signe Varner ,  Eugene Dejuan ,  Terry Shelley ,  Aaron Barnes ,  Mark Humayun

发明人： Signe Varner ,  Eugene Dejuan ,  Terry Shelley ,  Aaron Barnes ,  Mark Humayun

IPC分类号： A61F9/007 ,  A61B17/00 ,  A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61K45/00 ,  A61L31/00 ,  A61P27/02 ,  A61M31/00

CPC分类号： A61K9/0051 ,  A61B2017/00867 ,  A61F9/0017

摘要： An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

摘要翻译： 可以允许的治疗剂递送装置特别适合于将治疗剂递送到有限的进入区域，例如眼睛的后室和内耳。 本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。 本发明的优选输送装置还包括包含一个或多个物质的非线性形状的身体构件体和用于将一种或多种物质从非线性形状的身体构件持续递送至患者的输送机构的输送装置。

公开(公告)号：US10667404B2

公开(公告)日：2020-05-26

申请号：US11926046

申请日：2007-10-28

申请人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

发明人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

IPC分类号： A61N1/05 ,  H05K3/00 ,  A61N1/36

摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

公开(公告)号：US20150147377A1

公开(公告)日：2015-05-28

申请号：US14314994

申请日：2014-06-25

申请人： Mark Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David Hinton ,  Robert Grubbs ,  Dennis Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

发明人： Mark Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David Hinton ,  Robert Grubbs ,  Dennis Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

IPC分类号： A61L27/18 ,  A61L27/56

CPC分类号： A61L27/18 ,  A61K9/0051 ,  A61K35/30 ,  A61K35/545 ,  A61K47/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/00 ,  A61L2430/16 ,  Y10T428/24479

摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

摘要翻译： 本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。 衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

公开(公告)号：US20150032207A1

公开(公告)日：2015-01-29

申请号：US14114160

申请日：2012-04-27

申请人： Mark Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  Robert Grubbs ,  Rodrigo Brant ,  Trent Wells ,  Lincoln Vallance Johnson ,  Sherry T. Hikita ,  David Hinton

发明人： Mark Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  Robert Grubbs ,  Rodrigo Brant ,  Trent Wells ,  Lincoln Vallance Johnson ,  Sherry T. Hikita ,  David Hinton

IPC分类号： A61B17/29 ,  A61F2/46 ,  C12N5/079 ,  A61M5/14 ,  A61F9/00 ,  A61F2/14 ,  A61M1/12

CPC分类号： A61B17/2909 ,  A61B2017/2937 ,  A61B2017/2945 ,  A61B2017/305 ,  A61F2/14 ,  A61F2/4601 ,  A61F9/0017 ,  A61F9/00736 ,  A61K35/50 ,  A61L27/16 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/50 ,  A61L2430/16 ,  A61M1/12 ,  A61M5/14 ,  A61M2202/09 ,  C12N5/0621 ,  C12N2506/02 ,  C12N2533/30 ,  C12N2533/40 ,  C12N2533/50 ,  C08L65/04 ,  C08L89/00

摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

摘要翻译： 本文公开了用于将底物（包括细胞接种的底物）递送至需要治疗诱导细胞死亡，损伤或功能丧失的各种疾病的靶组织的仪器和方法。 衬底被配置为提供包括干细胞的细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

公开(公告)号：US08903475B2

公开(公告)日：2014-12-02

申请号：US12718186

申请日：2010-03-05

申请人： Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

发明人： Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

IPC分类号： A61B6/00 ,  A61B8/08 ,  A61B5/00 ,  A61M25/01 ,  A61B18/20 ,  A61B19/00 ,  A61B8/12 ,  A61B17/00 ,  A61N5/00

CPC分类号： A61B5/0066 ,  A61B3/10 ,  A61B3/102 ,  A61B3/14 ,  A61B5/0073 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/5276 ,  A61B18/20 ,  A61B34/20 ,  A61B2017/00207 ,  A61B2017/00694 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/061 ,  A61B2090/3735 ,  A61B2090/3954 ,  A61M25/01 ,  A61M2025/0166 ,  A61N5/00 ,  Y10T29/49826

摘要： A device includes a handpiece having a probe tip disposed at an end thereof, and, connected to the handpiece such that, at the probe tip, a functionality of each is provided, a plurality of probes. The probes may include an optical coherence tomography (OCT) probe, an endoillumination probe, a laser therapy probe, an ultrasound imaging probe, an electrocautery probe, an RF ablation probe, a cryosurgical probe, an irrigator, and/or a mechanical probe.

摘要翻译： 一种装置包括具有设置在其端部的探针尖端的手持件，并且连接到所述手持件，使得在所述探针尖端处提供每个的功能，多个探针。 探针可以包括光学相干断层扫描（OCT）探针，内窥镜探针，激光治疗探针，超声成像探针，电灼探针，RF消融探针，冷冻手术探针，冲洗器和/或机械探针。

公开(公告)号：US08585630B2

公开(公告)日：2013-11-19

申请号：US13555329

申请日：2012-07-23

申请人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

发明人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

IPC分类号： A61M5/00

CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

公开(公告)号：US20120330102A1

公开(公告)日：2012-12-27

申请号：US13479798

申请日：2012-05-24

申请人： Jeffrey Brennan ,  Mark Humayun

发明人： Jeffrey Brennan ,  Mark Humayun

IPC分类号： A61B1/07

CPC分类号： A61B5/0059 ,  A61B1/0002 ,  A61B1/00094 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00179 ,  A61B1/00188 ,  A61B1/018 ,  A61B1/313 ,  A61B3/102 ,  A61B5/0066 ,  A61F9/00763 ,  A61M5/178

摘要： An imaging probe may utilize a suitably shaped lens structure to deflect light off-axis, allowing for the acquisition of B-scans by rotary or reciprocating motion of the lens.

摘要翻译： 成像探针可以利用适当成形的透镜结构使光偏离轴，允许通过透镜的旋转或往复运动来获取B扫描。

公开(公告)号：US20120234433A1

公开(公告)日：2012-09-20

申请号：US13419968

申请日：2012-03-14

申请人： Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

发明人： Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

IPC分类号： B65B31/00

CPC分类号： A61M5/14276

摘要： A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir.

摘要翻译： 一种用于重新填充具有至少一个储存器的可植入泵的工具。 该工具包括多个独立的流体通道; 流体储存器，其与所述流体通道中的第一流体流体连通; 流体地联接到流体通道的至少一个泵，所述至少一个泵和独立流体通道在数量上彼此不同，其中（i）泵构造成对第一流体通道施加正压以驱动流体 并且（ii）泵构造成对第二流体通道施加负压; 以及用于将所述流体通道可移除地连接到所述至少一个储存器的连接器。