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公开(公告)号：US20170258846A1
公开(公告)日：2017-09-14
申请号：US15595719
申请日：2017-05-15
IPC分类号： A61K35/28 , A61K45/06 , C12N5/0775 , A61K35/12
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要： A method for suppressing T cell activation which comprises contacting a cell population comprising T cells in vitro or ex vivo with an effective amount of STRO-1+ cells and/or soluble factors derived therefrom to suppress T cell activation.
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公开(公告)号：US08828375B2
公开(公告)日：2014-09-09
申请号：US13061693
申请日：2009-09-03
IPC分类号： A61K38/20 , A61K35/14 , A61K38/19 , A61P35/02 , A61P35/00 , A61P7/00 , A61P19/02 , A61P31/12 , A61P31/06 , A61P7/06 , C12N5/0789 , A61K35/12
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/124 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/26 , C12N2502/1352 , C12N2502/1358
摘要： The present invention relates to a method of transplanting haematopoietic precursor cells into a subject in need thereof which involves culturing the haematopoietic precursor cells in the presence of a population of cells enriched for STRO-1bright cells. The method of the present invention is useful in the treatment of haematological disorders.
摘要翻译： 本发明涉及将造血前体细胞移植到有需要的受试者中的方法，其涉及在富含STRO-1Bight细胞的细胞群的存在下培养造血前体细胞。 本发明的方法可用于治疗血液病。
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公开(公告)号：US20160361363A1
公开(公告)日：2016-12-15
申请号：US15055221
申请日：2016-02-26
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
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公开(公告)号：US20130171113A1
公开(公告)日：2013-07-04
申请号：US13808093
申请日：2011-07-04
IPC分类号： A61K35/28
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
摘要翻译： 一种用于预防哺乳动物患者的GvHD并发症的发展或治疗的方法，其包括向所述哺乳动物施用富含STRO-1bright细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。
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公开(公告)号：US20130171099A1
公开(公告)日：2013-07-04
申请号：US13808092
申请日：2011-07-04
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要： A method for suppressing T cell activation which comprises contacting a cell population comprising T cells in vitro or ex viva with an effective amount of STRO-1+ cells and/or soluble factors derived therefrom to suppress cell activation.
摘要翻译： 一种抑制T细胞活化的方法，其包括使包含T细胞的细胞群体与有效量的STRO-1 +细胞和/或从其衍生的可溶性因子接触以抑制细胞活化。
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公开(公告)号：US09415072B2
公开(公告)日：2016-08-16
申请号：US14476467
申请日：2014-09-03
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/124 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/26 , C12N2502/1352 , C12N2502/1358
摘要： The present invention relates to a method of transplanting haematopoietic precursor cells into a subject in need thereof which involves culturing the haematopoietic precursor cells in the presence of a population of cells enriched for STRO-1bright cells. The method of the present invention is useful in the treatment of haematological disorders.
摘要翻译： 本发明涉及将造血前体细胞移植到有需要的受试者中的方法，其涉及在富含STRO-1Bight细胞的细胞群的存在下培养造血前体细胞。 本发明的方法可用于治疗血液病。
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公开(公告)号：US09301978B2
公开(公告)日：2016-04-05
申请号：US13808093
申请日：2011-07-04
IPC分类号： A61K35/28 , C12N5/0775 , A61K45/06 , A61K35/12
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/122 , A61P37/02 , C12N5/0663
摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
摘要翻译： 一种用于预防哺乳动物患者的GvHD并发症的发展或治疗的方法，其包括向所述哺乳动物施用富含STRO-1bright细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。
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公开(公告)号：US20150202232A1
公开(公告)日：2015-07-23
申请号：US14476467
申请日：2014-09-03
IPC分类号： A61K35/28 , C12N5/0789 , A61K45/06
CPC分类号： A61K35/28 , A61K45/06 , A61K2035/124 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/26 , C12N2502/1352 , C12N2502/1358
摘要： The present invention relates to a method of transplanting haematopoietic precursor cells into a subject in need thereof which involves culturing the haematopoietic precursor cells in the presence of a population of cells enriched for STRO-1bright cells. The method of the present invention is useful in the treatment of haematological disorders.
摘要翻译： 本发明涉及将造血前体细胞移植到有需要的受试者中的方法，其涉及在富含STRO-1Bight细胞的细胞群的存在下培养造血前体细胞。 本发明的方法可用于治疗血液病。
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