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公开(公告)号：US11951174B2
公开(公告)日：2024-04-09
申请号：US18301761
申请日：2023-04-17
Applicant: Singh Biotechnology, LLC
Inventor： Sunanda Singh
CPC classification number: A61K47/6811 , A61K38/162 , A61K38/177 , A61K47/643 , A61K47/644 , A61P31/14
Abstract: This invention provides compositions and methods to treat, prevent, and diagnose viral infections. The methods provided herein involve administering polypeptides of the invention to a subject in need thereof. The viral infections can be caused by a coronavirus such as SARS-CoV-1, SARS-CoV-2 or a variant thereof. It is contemplated that the polypeptide can be further linked to a compound, wherein the compound extends the serum half-life of the polypeptide.
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公开(公告)号：US20230277681A1
公开(公告)日：2023-09-07
申请号：US18301761
申请日：2023-04-17
Applicant: Singh Biotechnology, LLC
Inventor： Sunanda Singh
CPC classification number: A61K47/6811 , A61K47/643 , A61P31/14 , A61K38/177 , A61K38/162 , A61K47/644
Abstract: This invention provides compositions and methods to treat, prevent, and diagnose viral infections. The methods provided herein involve administering polypeptides of the invention to a subject in need thereof. The viral infections can be caused by a coronavirus such as, for example, SARS-CoV-1, SARS-CoV-2 or a variant thereof. It is contemplated that the polypeptide can be further linked to a compound, wherein the compound extends the serum half-life of the polypeptide
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公开(公告)号：US20240101652A1
公开(公告)日：2024-03-28
申请号：US17822642
申请日：2022-08-26
Applicant: Singh Biotechnology, LLC
Inventor： Sunanda Singh
CPC classification number: C07K16/18 , A61P35/00 , C07K2317/569 , C07K2317/82
Abstract: This invention provides compositions and methods to prevent aberrant cell proliferation in a subject using a single-domain antibody (sdAb) directed against an intracellular component, wherein the aberrant cell proliferation can be cancer. The sdAb is synergistic with one or more chemotherapeutic drugs and improves therapeutic efficacy of the one or more chemotherapeutic drug against cancer.
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公开(公告)号：US20170121395A1
公开(公告)日：2017-05-04
申请号：US15342032
申请日：2016-11-02
Applicant: SINGH BIOTECHNOLOGY, LLC
Inventor： Sunanda Singh
IPC: C07K16/10 , A61K45/06 , G01N33/573 , A61K39/42
CPC classification number: A61K45/06 , A61K39/42 , A61K2039/505 , A61P31/12 , C07K16/1045 , C07K16/40 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2317/92 , G01N33/56983 , G01N33/573 , G01N2333/08 , G01N2333/9128 , G01N2469/10
Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against targets that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
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公开(公告)号：US20170121392A1
公开(公告)日：2017-05-04
申请号：US15342044
申请日：2016-11-02
Applicant: SINGH BIOTECHNOLOGY, LLC
Inventor： Sunanda Singh
IPC: C07K16/10 , G01N33/569
CPC classification number: A61K45/06 , A61K39/42 , A61K2039/505 , A61P31/12 , C07K16/10 , C07K16/1045 , C07K16/1072 , C07K16/40 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2317/92 , C12N2760/14111 , G01N33/56983 , G01N33/573 , G01N2333/08 , G01N2333/9128 , G01N2469/10
Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against targets that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
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Patent Agency Ranking
公开(公告)号：US11370847B2
公开(公告)日：2022-06-28
申请号：US16195542
申请日：2018-11-19
Applicant: Singh Biotechnology, LLC
Inventor： Sunanda Singh
IPC: A61K39/00 , C07K16/46 , C12Q1/68 , A61K39/395 , A61K45/06 , A61K31/704 , C07K16/18 , C07K16/24 , C07K16/30 , C07K16/32 , C07K16/00 , C12N15/00
Abstract: This invention provides compositions and methods to prevent aberrant cell proliferation in a subject using a single-domain antibody (sdAb) directed against an intracellular component, wherein the aberrant cell proliferation can be cancer. The sdAb is synergistic with one or more chemotherapeutic drugs and improves therapeutic efficacy of the one or more chemotherapeutic drug against cancer. The invention also includes a method of treating viral infections using a sdAb, wherein the sbAb inhibits the replication of viruses such as Ebola virus and Zika virus in infected cells.
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公开(公告)号：US10369223B2
公开(公告)日：2019-08-06
申请号：US15342044
申请日：2016-11-02
Applicant: SINGH BIOTECHNOLOGY, LLC
Inventor： Sunanda Singh
IPC: A61K39/42 , A61K45/06 , G01N33/569 , C07K16/10 , G01N33/573 , C07K16/40 , A61P31/12 , A61K39/00
Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against targets that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
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公开(公告)号：US10195277B2
公开(公告)日：2019-02-05
申请号：US15342032
申请日：2016-11-02
Applicant: SINGH BIOTECHNOLOGY, LLC
Inventor： Sunanda Singh
IPC: C07K16/10 , A61K45/06 , G01N33/569 , A61K39/42 , G01N33/573 , C07K16/40 , A61P31/12 , A61K39/00
Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against targets that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
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公开(公告)号：US20180072815A1
公开(公告)日：2018-03-15
申请号：US15823295
申请日：2017-11-27
Applicant: SINGH BIOTECHNOLOGY, LLC
Inventor： Sunanda Singh
CPC classification number: C07K16/468 , A61K31/704 , A61K39/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/241 , C07K16/3015 , C07K16/32 , C07K2317/22 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C12N15/00 , C12Q1/68 , Y02A50/392 , Y02A50/394 , Y02A50/466 , A61K2300/00
Abstract: This invention provides compositions and methods to prevent aberrant cell proliferation in a subject using a single-domain antibody (sdAb) directed against an intracellular component, wherein the aberrant cell proliferation can be cancer. The sdAb is synergistic with one or more chemotherapeutic drugs and improves therapeutic efficacy of the one or more chemotherapeutic drug against cancer. The invention also includes a method of treating viral infections using a single-domain antibody (sdAb), wherein the sbAb inhibits the replication of Ebola viruses and Zika viruses in infected cells.
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公开(公告)号：US20240238437A1
公开(公告)日：2024-07-18
申请号：US18596026
申请日：2024-03-05
Applicant: Singh Biotechnology, LLC
Inventor： Sunanda Singh
CPC classification number: A61K47/6811 , A61K38/162 , A61K38/177 , A61K47/643 , A61K47/644 , A61P31/14
Abstract: This invention provides compositions and methods to treat, prevent, and diagnose viral infections. The methods provided herein involve administering polypeptides of the invention to a subject in need thereof. The viral infections can be caused by a coronavirus such as SARS-CoV-1, SARS-CoV-2 or a variant thereof. It is contemplated that the polypeptide can be further linked to a compound, wherein the compound extends the serum half-life of the polypeptide.
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