公开(公告)号：US20220265595A1

公开(公告)日：2022-08-25

申请号：US17606884

申请日：2020-04-30

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  David COUSIN ,  Matthew Colin Thor FYFE ,  Barry John TEOBALD ,  Stephen Malcolm THOM ,  Thomas Michael WAUGH

IPC: A61K31/225 ,  C07C255/14 ,  C07C317/18 ,  C07C69/593 ,  C07D305/08 ,  C07D207/27 ,  C07C233/05 ,  C07D207/273 ,  C07C311/03 ,  C07C219/08 ,  C07D307/20 ,  C07D309/12 ,  C07D211/96 ,  C07D295/08 ,  C07D331/04 ,  C07D205/04 ,  C07D295/088 ,  C07D207/277 ,  C07D257/04 ,  C07D519/00 ,  C07D451/10 ,  A61K31/275 ,  A61K31/337 ,  A61K31/4015 ,  A61K31/341 ,  A61K31/351 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/38 ,  A61K31/397 ,  A61K31/495 ,  A61K31/54 ,  A61K31/41 ,  A61K31/46

Abstract: The invention relates to compounds of formula (IW-1) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA, RB, RC and RD are as defined herein.

公开(公告)号：US20230219907A1

公开(公告)日：2023-07-13

申请号：US17787870

申请日：2020-12-23

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  David COUSIN ,  Matthew Colin Thor FYFE ,  Thomas Michael WAUGH ,  Saleh AHMED ,  Alessio DE SIMONE ,  Barry John TEOBALD

IPC: C07D271/06 ,  A61K45/06 ,  C07D277/24 ,  C07D263/32 ,  A61P37/06

CPC classification number: C07D271/06 ,  A61K45/06 ,  C07D277/24 ,  C07D263/32 ,  A61P37/06

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.