公开(公告)号：US20240245691A1

公开(公告)日：2024-07-25

申请号：US18557183

申请日：2022-04-26

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Michael Liam COOKE ,  David COUSIN ,  Saleh AHMED ,  Alessandro MAZZACANI

IPC: A61K31/5375 ,  A61K31/18 ,  A61K31/192 ,  A61K31/337 ,  A61K31/38 ,  A61K31/41 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/445 ,  A61K45/06 ,  A61P29/00 ,  C07C233/13 ,  C07C233/14 ,  C07C311/04 ,  C07D211/46 ,  C07D211/96 ,  C07D213/26 ,  C07D257/04 ,  C07D295/088 ,  C07D305/08 ,  C07D401/12 ,  C07D409/12

CPC classification number: A61K31/5375 ,  A61K31/18 ,  A61K31/192 ,  A61K31/337 ,  A61K31/38 ,  A61K31/41 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/445 ,  A61K45/06 ,  A61P29/00 ,  C07C233/13 ,  C07C233/14 ,  C07C311/04 ,  C07D211/46 ,  C07D211/96 ,  C07D213/26 ,  C07D257/04 ,  C07D295/088 ,  C07D305/08 ,  C07D401/12 ,  C07D409/12

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA, RZ, RC, RD, RF and RG are as defined herein.

公开(公告)号：US20230399289A1

公开(公告)日：2023-12-14

申请号：US18034143

申请日：2021-10-29

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Barry John TEOBALD

IPC: C07C69/75 ,  C07D305/08 ,  C07C69/743 ,  C07C323/22 ,  A61P29/00

CPC classification number: C07C69/75 ,  C07D305/08 ,  C07C69/743 ,  C07C323/22 ,  A61P29/00 ,  C07C2601/16 ,  C07C2601/04

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA1, RA2, R1 to R5, L and RB are as defined herein.

公开(公告)号：US20230381132A1

公开(公告)日：2023-11-30

申请号：US18034122

申请日：2021-10-27

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Barry John TEOBALD

IPC: A61K31/225 ,  A61K45/06 ,  A61P37/06 ,  C07C69/593

CPC classification number: A61K31/225 ,  A61K45/06 ,  A61P37/06 ,  C07C69/593

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA1, RA2, RA3, RB, RC, RD, m, n and p are as defined herein.

公开(公告)号：US20220265595A1

公开(公告)日：2022-08-25

申请号：US17606884

申请日：2020-04-30

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  David COUSIN ,  Matthew Colin Thor FYFE ,  Barry John TEOBALD ,  Stephen Malcolm THOM ,  Thomas Michael WAUGH

IPC: A61K31/225 ,  C07C255/14 ,  C07C317/18 ,  C07C69/593 ,  C07D305/08 ,  C07D207/27 ,  C07C233/05 ,  C07D207/273 ,  C07C311/03 ,  C07C219/08 ,  C07D307/20 ,  C07D309/12 ,  C07D211/96 ,  C07D295/08 ,  C07D331/04 ,  C07D205/04 ,  C07D295/088 ,  C07D207/277 ,  C07D257/04 ,  C07D519/00 ,  C07D451/10 ,  A61K31/275 ,  A61K31/337 ,  A61K31/4015 ,  A61K31/341 ,  A61K31/351 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/38 ,  A61K31/397 ,  A61K31/495 ,  A61K31/54 ,  A61K31/41 ,  A61K31/46

Abstract: The invention relates to compounds of formula (IW-1) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA, RB, RC and RD are as defined herein.

公开(公告)号：US20240335451A1

公开(公告)日：2024-10-10

申请号：US18572126

申请日：2022-06-22

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Alessandro MAZZACANI ,  Barry John TEOBALD ,  Michael Liam COOKE ,  Saleh AHMED

IPC: A61K31/5375 ,  A61K31/165 ,  A61K31/337 ,  A61K31/38 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K45/06 ,  A61P29/00 ,  A61P37/06 ,  C07C235/76 ,  C07D211/58 ,  C07D213/30 ,  C07D241/20 ,  C07D271/06 ,  C07D305/08 ,  C07D331/04 ,  C07D413/12

CPC classification number: A61K31/5375 ,  A61K31/165 ,  A61K31/337 ,  A61K31/38 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K45/06 ,  A61P29/00 ,  A61P37/06 ,  C07C235/76 ,  C07D211/58 ,  C07D213/30 ,  C07D241/20 ,  C07D271/06 ,  C07D305/08 ,  C07D331/04 ,  C07D413/12

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA, RB, RC and RD are as defined herein.

公开(公告)号：US20230399287A1

公开(公告)日：2023-12-14

申请号：US18034501

申请日：2021-10-29

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Barry John TEOBALD

IPC: C07C69/65 ,  C07D213/26 ,  C07D305/06 ,  C07D333/12 ,  C07D331/04 ,  C07D241/12 ,  C07D237/08 ,  C07D405/04 ,  A61P1/16

CPC classification number: C07C69/65 ,  C07D213/26 ,  C07D305/06 ,  C07D333/12 ,  C07D331/04 ,  C07D241/12 ,  C07D237/08 ,  C07D405/04 ,  A61P1/16

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein A, L, RA1, RA2, RC and RD are as defined herein.

公开(公告)号：US20230219907A1

公开(公告)日：2023-07-13

申请号：US17787870

申请日：2020-12-23

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  David COUSIN ,  Matthew Colin Thor FYFE ,  Thomas Michael WAUGH ,  Saleh AHMED ,  Alessio DE SIMONE ,  Barry John TEOBALD

IPC: C07D271/06 ,  A61K45/06 ,  C07D277/24 ,  C07D263/32 ,  A61P37/06

CPC classification number: C07D271/06 ,  A61K45/06 ,  C07D277/24 ,  C07D263/32 ,  A61P37/06

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

公开(公告)号：US20240409542A1

公开(公告)日：2024-12-12

申请号：US18696563

申请日：2022-09-30

Applicant: Sitryx Therapeutics Limited

Inventor： David COUSIN ,  Matthew Colin Thor FYFE ,  Oscar BARBA

IPC: C07D471/14 ,  A61K31/5025 ,  A61K45/06 ,  C07D519/00

Abstract: The invention relates to compounds of formula (Ia) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: wherein RA, RB, RC and RD, X, m and n are as defined herein.

公开(公告)号：US20240360067A1

公开(公告)日：2024-10-31

申请号：US18682780

申请日：2022-08-11

Applicant: Sitryx Therapeutics Limited

Inventor： Michael Liam COOKE ,  Matthew Colin Thor FYFE ,  Alessandro MAZZACANI

IPC: C07C69/618 ,  A61K31/225 ,  A61K31/337 ,  A61K31/351 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/5375 ,  C07C235/76 ,  C07C237/16 ,  C07D211/58 ,  C07D213/55 ,  C07D233/64 ,  C07D295/15 ,  C07D305/08 ,  C07D309/14 ,  C07D331/04 ,  C07D333/24

CPC classification number: C07C69/618 ,  A61K31/225 ,  A61K31/337 ,  A61K31/351 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/5375 ,  C07C235/76 ,  C07C237/16 ,  C07D211/58 ,  C07D213/55 ,  C07D233/64 ,  C07D295/15 ,  C07D305/08 ,  C07D309/14 ,  C07D331/04 ,  C07D333/24 ,  C07C2601/04 ,  C07C2601/16

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA and RB are as defined herein.

公开(公告)号：US20240018111A1

公开(公告)日：2024-01-18

申请号：US18019632

申请日：2021-08-05

Applicant: Sitryx Therapeutics Limited

Inventor： Saleh AHMED ,  Michael Liam COOKE ,  Matthew Colin Thor FYFE

IPC: C07D271/06 ,  C07D413/12 ,  A61P29/00

CPC classification number: C07D271/06 ,  C07D413/12 ,  A61P29/00

Abstract: The invention relates to compounds of formula (I):




wherein A, RA1, RA2, RB, RC and RD are as defined herein, and associated aspects.