公开(公告)号：US20150152573A1

公开(公告)日：2015-06-04

申请号：US14409475

申请日：2013-06-19

Applicant: JNC CORPORATION ,  SofSera Corporation

Inventor： Yasumichi Kogai ,  Daisuke Nomi ,  Hisashi Hattori ,  Karl Kazushige Kawabe ,  You Umebayashi ,  Yukinori Kataoka ,  Minoru Miyauchi

IPC: D01F9/08 ,  C01B25/32 ,  D01D5/00

CPC classification number: D01F9/08 ,  C01B25/32 ,  C01B25/321 ,  D01D5/0007 ,  D01D5/0015 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0038 ,  D01D5/0046 ,  D10B2101/10

Abstract: To provide a method for producing a porous calcium phosphate body having open micropores.A porous calcium phosphate body having open and uniform micropores can be produced by the method for producing the porous calcium phosphate body, in which calcium phosphate is subjected to electrospinning.

Abstract translation: 提供一种具有开放微孔的多孔磷酸钙体的制造方法。 具有开放均匀微孔的多孔磷酸钙体可以通过磷酸钙进行静电纺丝的多孔磷酸钙体的制造方法来制造。

公开(公告)号：US11168031B2

公开(公告)日：2021-11-09

申请号：US16328629

申请日：2017-08-30

Applicant: SofSera Corporation

Inventor： Yasumichi Kogai ,  Nobuo Aoi ,  Daisuke Nomi ,  Karl Kazushige Kawabe

IPC: C04B35/447 ,  A61K6/838 ,  A61L27/32 ,  C01B25/32 ,  C04B35/64

Abstract: This invention has an object to provide a means for providing a calcium phosphate sintered body particle group that does not cause a phenomenon of bubble generation in any use mode thereof, and further has a smaller particle diameter.
There is provided a ceramic particle group containing spherical ceramic particles, which is characterized in that the ceramic particle has a particle diameter within a range of 10 nm to 700 nm, and is a calcium phosphate sintered body particle, and further the ceramic particle group contains no calcium carbonate.

公开(公告)号：US20180353598A1

公开(公告)日：2018-12-13

申请号：US15761058

申请日：2016-09-16

Applicant: National Institutes of Biomedical Innovation, Health and Nutrition ,  SofSera Corporation

Inventor： Ken Ishii ,  Masayuki Hayashi ,  Yasumichi Kogai ,  Daisuke Nomi ,  Karl Kazushige Kawabe

IPC: A61K39/39 ,  A61K9/14

CPC classification number: A61K39/39 ,  A61K9/14 ,  A61K39/00 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: Provided is an improved biocompatible immune adjuvant. More specifically, provided are: an immune adjuvant that comprises calcium phosphate, preferably hydroxyapatite, having an average particle size of about 40 nm exclusive to about 1800 nm exclusive; a medicine that comprises this immune adjuvant; and a vaccine that comprises this immune adjuvant. Rod-shaped HAp induced inflammasome-dependent IL-1β production in vitro more strongly than spherical HAp. In WT mice, however, spherical HAp and rod-shaped HAp induced equivalent antigen responses.

公开(公告)号：US09896782B2

公开(公告)日：2018-02-20

申请号：US14409475

申请日：2013-06-19

Applicant: JNC CORPORATION ,  SofSera Corporation

Inventor： Yasumichi Kogai ,  Daisuke Nomi ,  Hisashi Hattori ,  Karl Kazushige Kawabe ,  You Umebayashi ,  Yukinori Kataoka ,  Minoru Miyauchi

IPC: D01F9/08 ,  D01D5/00 ,  C01B25/32

CPC classification number: D01F9/08 ,  C01B25/32 ,  C01B25/321 ,  D01D5/0007 ,  D01D5/0015 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0038 ,  D01D5/0046 ,  D10B2101/10

Abstract: To provide a method for producing a porous calcium phosphate body having open micro-pores, by the method for producing the porous calcium phosphate body, in which calcium phosphate is subjected to electro-spinning.

公开(公告)号：US11504452B2

公开(公告)日：2022-11-22

申请号：US16328720

申请日：2017-08-30

Applicant: SofSera Corporation

Inventor： Yasumichi Kogai ,  Nobuo Aoi ,  Daisuke Nomi ,  Karl Kazushige Kawabe

IPC: A61L31/02 ,  A61L15/18 ,  A61L27/10 ,  A61L29/02 ,  C01B25/32 ,  C04B35/447 ,  C04B35/622 ,  A61L31/12 ,  A61L29/12 ,  A61L15/64 ,  A61L27/40 ,  B82Y5/00 ,  A61L27/46 ,  A61K6/838

Abstract: To provide a ceramic particle separable composite material having a calcium phosphate sintered body particle with which bioaffinity reduction and solubility change are suppressed as much as possible and which has a smaller particle diameter.
A ceramic particle separable composite material comprising a ceramic particle and a substrate, wherein: the ceramic particle and the substrate are chemically bonded to each other, or the ceramic particle physically adheres to or is embedded in the substrate; the ceramic particle has a particle diameter within a range of 10 nm to 700 nm; the ceramic particle is a calcium phosphate sintered body particle; and the ceramic particle contains no calcium carbonate.

公开(公告)号：US20200181026A1

公开(公告)日：2020-06-11

申请号：US16313686

申请日：2016-08-30

Applicant: SofSera Corporation

Inventor： Yasumichi Kogai ,  Nobuo Aoi ,  Daisuke Nomi ,  Karl Kazushige Kawabe

IPC: C04B35/447

Abstract: This invention has an object to provide a means for providing a calcium phosphate sintered body particle group that does not cause a phenomenon of bubble generation in any use mode thereof, and further has a smaller particle diameter.There is provided a ceramic particle group containing spherical ceramic particles, which is characterized in that the ceramic particle has a particle diameter within a range of 10 nm to 700 nm, and is a calcium phosphate sintered body particle, and further the ceramic particle group contains no calcium carbonate.